The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Inhibitory Effects of Chestnut Inner Shell Cytokine Production from Human Mast Cell Line

율피추출물의 사람 비만세포주 사이토카인 발현 억제 효과

  • Jun, Dong-Ha (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Jang, Young-Ah (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Kim, Hui-Yeong (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Kim, Su-Jin (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Kim, Jin-Chul (THURINGEN KOREA Co., Ltd) ;
  • Kim, Sea-Hyun (Korea Forest Research Institute) ;
  • Kwoen, Dae-Jun (Biohealth convergence Center, Technopark) ;
  • Han, Sang-Ik (Department of Functional Crop, National Institute of Crop Science) ;
  • Lee, Jin-Tae (Department of Cosmeceutical Science, Daegu Haany University)
  • 전동하 (대구한의대학교 화장품약리학과) ;
  • 장영아 (대구한의대학교 화장품약리학과) ;
  • 김희영 (대구한의대학교 화장품약리학과) ;
  • 김수진 (대구한의대학교 화장품약리학과) ;
  • 김진철 (튜링겐코리아) ;
  • 김세현 (국립산림과학원) ;
  • 권대준 (대구테크노파크 바이오헬스융합센터) ;
  • 한상익 (국립식량과학원) ;
  • 이진태 (대구한의대학교 화장품약리학과)
  • Received : 2013.02.13
  • Accepted : 2013.03.22
  • Published : 2013.03.30
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Abstract

Objectives : Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczematous inflammtion of the skin. The chestnut inner shell extracts (CI) has been used as a cosmetic material for a long time in Korea. However, the precise anti-allergy effects of CI have yet to be clearly elucidated. In this study, we attempted to evaluate the effect of CI on mast cell-mediated allergy inflammation. Methods : To find the anti-allergy and inflammatory effect of CI, we investigated the inhibitory effect of CI on the production of inflammatory mediators using by enzyme-linked immunosorbent assay in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187) stimulated-human mast cell (HMC-1). Results : In this study, we found that CI did not show cytotoxic effect at up to 10 ug/ml on HMC-1. CI inhibited the production of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-6 and IL-8 in stimulated HMC-1. Maximal rate of TNF-${\alpha}$, IL-6 and IL-8 inhibition by CI (10 ug/ml) were about 47.6%, 44.1% and 22.5% respectively. In addition, we showed that Fr.3 isolated from n-Butyl alcohol layer of CI attenuated the production of TNF-${\alpha}$, IL-6 and IL-8 in HMC-1. Conclusion : Taken together, the findings of this study provide us with a novel insight action of CI as a potential molecule for use in the treatment of allergic inflammation diseases.

Keywords

References

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