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The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Evaluation of Antioxidant and Anti-Inflammatory Activities of Ascidian Tunic Carotenoids As a Source of Color Cosmetics

멍게껍질 카로테노이드의 색조 화장품 원료의 항산화, 항염증 기능성 평가

  • Ticar, Bernadeth (Department of Seafood Science and Technology/The Institue of Marine Industry, Gyeongsang National University) ;
  • Rohmah, Zuliyati (Department of Seafood Science and Technology/The Institue of Marine Industry, Gyeongsang National University) ;
  • Bat-Erdene, Munkhjagal (Department of Seafood Science and Technology/The Institue of Marine Industry, Gyeongsang National University) ;
  • Park, Si-Hyang (Sunmarine Biotech Co.) ;
  • Choi, Byeong-Dae (Department of Seafood Science and Technology/The Institue of Marine Industry, Gyeongsang National University)
  • Received : 2012.09.25
  • Accepted : 2013.02.25
  • Published : 2013.02.27
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Abstract

Carotenoids are fat-soluble red-orange colored pigments found in plants and seafood-derived products, including algae, seaweeds, and fish muscle. In this study, we have demonstrated the molecular mechanism underlying the antioxidants and anti-inflammatory properties of ascidian tunic carotenoids using mouse macrophage cell line (RAW 264.7). Cell viability was not affected by treatment of carotenoids < 10 ${\mu}g/mL$. This treatment also showed negative inhibition on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) and cyclooxygenase-2 (COX-2). The DPPH radical scavenging activity of carotenoids was 47.2% at 100 mg/mL. It also has a potential reducing power (1.025) comparable with ascorbic acid (1.584). The ascidian tunic carotenoids would make a candidate for the commercially interesting biologically active cosmetic pigments.

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