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Protective effects of red ginseng extract against vaginal herpes simplex virus infection

  • Cho, Ara (Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University) ;
  • Roh, Yoon Seok (Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University) ;
  • Uyangaa, Erdenebileg (Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University) ;
  • Park, Surim (Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University) ;
  • Kim, Jong Won (Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University) ;
  • Lim, Kyu Hee (Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University) ;
  • Kwon, Jungkee (Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University) ;
  • Eo, Seong Kug (Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University) ;
  • Lim, Chae Woong (Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University) ;
  • Kim, Bumseok (Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University)
  • Received : 2012.10.17
  • Accepted : 2012.11.07
  • Published : 2013.04.15

Abstract

Numerous studies have suggested that Korean red ginseng (KRG) extract has various immune modulatory activities both in vivo and in vitro. In this study, we used a mouse model to examine the effects of orally administered KRG extract on immunity against herpes simplex virus (HSV). Balb/c mice were administered with 100, 200, and 400 mg/kg oral doses of KRG extract for 10 d and then vaginally infected with HSV. We found that KRG extract rendered recipients more resistant against HSV vaginal infection and further systemic infection, including decreased clinical severity, increased survival rate, and accelerated viral clearance. Such results appeared to be mediated by increased vaginal IFN-${\gamma}$ secretion. Moreover, increased mRNA expression of IFN-${\gamma}$, granzyme B, and Fas-ligand was identified in the iliac lymph node and vaginal tracts of KRG extract treated groups (200 and 400 mg/kg). These results suggest that the activities of local natural killer cells were promoted by KRG extract consumption and that KRG may be an attractive immune stimulator for helping hosts overcome HSV infection.

Keywords

References

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