Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Investigation of the Correlation between Seoul Neuropsychological Screening Battery Scores and the Gray Matter Volume after Correction of Covariates of the Age, Gender, and Genotypes in Patients with AD and MCI

알츠하이머 치매 및 경도인지기능장애 환자에서 나이, 성별, 유전자형을 고려한 뇌 회백질 부피와 표준신경심리검사와의 상관관계 연구

  • Lee, Seung-Yeon (Department of Medicine, School of Medicine, Kyung Hee University) ;
  • Yoon, Soo-Young (Department of Medicine, School of Medicine, Kyung Hee University) ;
  • Kim, Min-Ji (Department of Radiology, Kyung Hee University Hospital at Gangdong) ;
  • Rhee, Hak Young (Department of Neurology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University) ;
  • Ryu, Chang-Woo (Department of Radiology, Kyung Hee University Hospital at Gangdong) ;
  • Jahng, Geon-Ho (Department of Radiology, Kyung Hee University Hospital at Gangdong)
  • 이승연 (경희대학교 의학전문대학원 의학과) ;
  • 윤수영 (경희대학교 의학전문대학원 의학과) ;
  • 김민지 (경희대학교 강동경희대학교병원 영상의학과) ;
  • 이학영 (경희대학교 의과대학 강동경희대학교병원 신경과) ;
  • 류창우 (경희대학교 강동경희대학교병원 영상의학과) ;
  • 장건호 (경희대학교 강동경희대학교병원 영상의학과)
  • Received : 2013.07.29
  • Accepted : 2013.09.09
  • Published : 2013.12.27
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Abstract

Purpose : To investigate the correlations between Seoul Neuropsychological Screening Battery (SNSB) scores and the gray matter volumes (GMV) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) and cognitively normal (CN) elderly subjects with correcting the genotypes. Materials and Methods: Total 75 subjects were enrolled with 25 subjects for each group. The apolipoprotein E (APOE) epsilon genotypes, SNSB scores, and the 3D T1-weighted images were obtained from all subjects. Correlations between SNSB scores and GMV were investigated with the multiple regression method for each subject group using both voxel-based and region-of-interest-based analyses with covariates of age, gender, and the genotype. Results: In the AD group, Rey Complex Figure Test (RCFT) delayed recall scores were positively correlated with GMV. In the MCI group, Seoul Verbal Learning Test (SVLT) scores were positively correlated with GMV. In the CN group, GMV negatively correlated with Boston Naming Test (K-BNT) scores and Mini-Mental State Examimation (K-MMSE) scores, but positively correlated with RCFT scores. Conclusion: When we used covariates of age, gender, and the genotype, we found statistically significant correlations between some SNSB scores and GMV at some brain regions. It may be necessary to further investigate a longitudinal study to understand the correlation.

목적 : 본 연구의 목적은 다양한 신경심리검사를 통해 알츠하이머 치매 및 경도인지장애 환자군과 정상 노인 대조군에서 뇌회색질 부피와 신경심리검사 (SNSB) 결과의 복셀 기반분석을 이용한 상관관계를 알아내는데 있다. 대상 및 방법 : 총 피험자는 75명으로, 정상노인 25명, 경도인지장애 환자 25명, 그리고 알츠하이머 치매 환자 25명이었다. 모든 피험자로부터 유전자검사, 표준신경심리검사 (SNSB), 해부학적인 삼차원 T1 강조영상을 자화준비 고속경사에코 시퀀스를 이용하여 얻었다. 각 피험자군에서 뇌 회색질의 용적변화와 신경심리검사 점수와의 상관관계를 관찰하기 위하여, 복셀기반과 관심영역 기반 방법을 이용하여 분할한 회색질 영상을 다중회기방식 (multiple regression)으로 통계처리 하였다. 이때 피험자 각각의 성별과 나이 및 유전자 보유형태를 공변량 (covariate) 값으로 넣어 그 차이를 고려하였다. 결과 : 알츠하이머 환자군에서는 레이 복합도형 그리기 지연회상 검사 (RCFT delayed recall) 점수가 낮을수록 뇌 회색질 용적이 감소했다. 경도인지 장애군에서는 서울 언어학습 검사 (SVLT) 점수가 낮을수록 뇌회색질 용적이 감소했다. 정상 피험자 군에서 한국형 보스턴 이름대기 검사 (K-BNT) 점수 및 한국형 간이정신상태 검사 (K-MMSE) 점수와 뇌 회색질 부피가 음의 상관관계가 있음을 보였고, 레이 복합도형 그리기 검사 (RCFT) 점수와는 양의 상관관계를 보여주고 있다. 결론 : 나이, 성별, 유전자형태를 공변량으로 사용하였을 때 뇌에서 신경심리검사 결과와 3D T1 강조영상에서 얻은 뇌 회색질 부피 사이에 통계적으로 유의한 상관관계가 있음을 밝혔다. 이들 피험자를 대상으로 하는 종적 연구가 이루어 져야 한다고 생각이 든다.

Keywords

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