Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
권호 표지
DOI QR코드

DOI QR Code

$H^1$ Magnetic Resonance Spectroscopy of Cystic Ovarian Lesions

낭성 난소병변의 자기공명분광술

  • Kang, Young Hye (Department of Radiology, Inha University School of Medicine) ;
  • Kim, Mi Young (Department of Radiology, Inha University School of Medicine) ;
  • Kim, Kyung Tae (Department of Radiology, Inha University School of Medicine) ;
  • Kim, Yoon Jung (Department of Radiology, Inha University School of Medicine) ;
  • Suh, Chang Hae (Department of Radiology, Inha University School of Medicine) ;
  • Kim, Jun Mee (Department of Pathology, Inha University School of Medicine) ;
  • Hwang, Sung Ook (Department of Gynecology, Inha University School of Medicine) ;
  • Park, Sunghyouk (College of pharmacology, Seoul National University) ;
  • Cho, Jae Young (Biology, New York University)
  • 강영혜 (인하대학교 의과대학 인하대병원 영상의학과) ;
  • 김미영 (인하대학교 의과대학 인하대병원 영상의학과) ;
  • 김경태 (인하대학교 의과대학 인하대병원 영상의학과) ;
  • 김윤정 (인하대학교 의과대학 인하대병원 영상의학과) ;
  • 서창해 (인하대학교 의과대학 인하대병원 영상의학과) ;
  • 김준미 (인하대학교 의과대학 인하대병원 병리과학) ;
  • 황성욱 (인하대학교 의과대학 인하대병원 산부인과학) ;
  • 박성혁 (서울대학교 약학대학) ;
  • 조재영 (뉴욕대학교 생물학)
  • Received : 2013.10.07
  • Accepted : 2013.12.17
  • Published : 2013.12.27
Download PDF
⟨ Previous Next ⟩

Abstract

On $H^1$ MRS (magnetic resonance spectroscopy), malignant tumors show higher concentration of metabolite than benign lesions. Lactate double peak was detected in malignant tumor and endometriosis, and more prominent high concentration was demonstrated in endometriosis. Tuboovarian abscesses and salpingitis do not show prominent peak. Dermoid cysts show high levels of lipid peak. Paratubal cyst and follicular cyst can be showed the lipid peak, however, the concentration of lipid is lower than that of dermoid cyst. $H^1$ MRS of ovarian cystic lesions can give valuable information about the presence of metabolites of ovarian cystic lesions.

$H^1$ 자기공명분광술에서 악성 종양은 양성 병변보다 더 높은 농도의 대사물질들을 보여준다. 락테이트의 이중 첨단점은 악성 종양과 자궁내막증에서 나타났으며, 자궁내막증에서 더 높은 농도를 보였다. 자궁관난소농양과 난관염은 분명한 첨단점이 보이지 않는다. 유피낭종은 높은 수준의 지질 첨단점이 나타난다. 부난관 낭종 및 난포낭도 지질 첨단점을 보일 수 있지만, 지질의 농도는 유피낭종보다 현저히 낮다. $H^1$ 자기공명분광술은 낭성 난소병변의 대사 물 성분에 대한 유용한 정보를 제공할 수 있다.

Keywords

References

  1. Imaoka I, Wada A, Kaji Y, et al. Developing an MR imaging strategy for diagnosis of ovarian masses. Radiographics 2006;26:1431-1448 https://doi.org/10.1148/rg.265045206
  2. Jung SE, Lee JM, Rha SE, et al. CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics 2002;22:1305-1325 https://doi.org/10.1148/rg.226025033
  3. Kawamoto S, Urban BA, Fishman EK. CT of epithelial ovarian tumors. Radiographics 1999;19 Spec No:S85-102;quiz S263-264 https://doi.org/10.1148/radiographics.19.suppl_1.g99oc10s85
  4. Sutton CL, McKinney CD, Jones JE, Gay SB. Ovarian masses revisited: radiologic and pathologic correlation. Radiographics 1992;12:853-877 https://doi.org/10.1148/radiographics.12.5.1529129
  5. Kolwijck E, Engelke UF, van der Graaf M, et al. N-acetyl resonances in in vivo and in vitro NMR spectroscopy of cystic ovarian tumors. NMR Biomed 2009;22:1093-1099
  6. Mahon MM, Williams AD, Soutter WP, et al. 1H magnetic resonance spectroscopy of invasive cervical cancer: an in vivo study with ex vivo corroboration. NMR Biomed 2004;17:1-9 https://doi.org/10.1002/nbm.830
  7. Burtscher IM, Holtas S. Proton MR spectroscopy in clinical routine. J Magn Reson Imaging 2001;13:560-567 https://doi.org/10.1002/jmri.1079
  8. Ross B, Michaelis T. Clinical applications of magnetic resonance spectroscopy. Magn Reson Q 1994;10:191-247
  9. Yoon SH, Park CM, Lee CH, Song IC, Lee HJ, Goo JM. Feasibility of in vivo proton magnetic resonance spectroscopy for lung cancer. J Korean Soc Magn Reson Med 2012;16:40-46 https://doi.org/10.13104/jksmrm.2012.16.1.40
  10. Okada T, Harada M, Matsuzaki K, Nishitani H, Aono T. Evaluation of female intrapelvic tumors by clinical proton MR spectroscopy. J Magn Reson Imaging 2001;13:912-917 https://doi.org/10.1002/jmri.1130
  11. Massuger LF, van Vierzen PB, Engelke U, Heerschap A, Wevers R. 1H-magnetic resonance spectroscopy: a new technique to discriminate benign from malignant ovarian tumors. Cancer 1998;82:1726-1730 https://doi.org/10.1002/(SICI)1097-0142(19980501)82:9<1731::AID-CNCR20>3.0.CO;2-4
  12. Park SH, Kim MY, Suh CH, Lee KY, Choi SJ, Cho JY. MR Images and 1H MR spectroscopy of enteric duplication cyst of the pancreas in an adult. J Korean Soc Magn Reson Med 2010; 14:139-144 https://doi.org/10.13104/jksmrm.2010.14.2.139
  13. Kim SH, Chang KH, Song IC, et al. Brain abscess and brain tumor: discrimination with in vivo H-1 MR spectroscopy. Radiology 1997;204:239-245 https://doi.org/10.1148/radiology.204.1.9205254
  14. Mun CW, Cho JY, Shin WJ, et al. Ex vivo proton MR spectroscopy (1H-MRS) for evaluation of human gastric carcinoma. Magn Reson Imaging 2004;22:861-70 https://doi.org/10.1016/j.mri.2004.01.045
  15. Hagberg H, Siegbahn A. Prognostic value of serum lactic dehydrogenase in non-Hodgkin's lymphoma. Scand. J. Haematol 1983;31:49-59
  16. Boss EA, Moolenaar SH, Massuger LF, et al. High-resolution proton nuclear magnetic resonance spectroscopy of ovarian cyst fluid. NMR Biomed 2000;13:297-305 https://doi.org/10.1002/1099-1492(200008)13:5<297::AID-NBM648>3.0.CO;2-I
  17. Comerci JT Jr., Licciardi F, Bergh PA, Gregori C, Breen JL. Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. Obstet Gynecol 1994;84:22- 28
  18. Outwater EK, Siegelman ES, Hunt JL. Ovarian teratomas: tumor types and imaging characteristics. Radiographics 2001;21:475-490 https://doi.org/10.1148/radiographics.21.2.g01mr09475
  19. Cho SW, Cho SG, Lee JH, et al. In-vivo proton magnetic resonance spectroscopy in adnexal lesions. Korean J Radiol 2002;3:105-112 https://doi.org/10.3348/kjr.2002.3.2.105
  20. Hascalik S, Celik O, Sarac K, et al. Metabolic changes in pelvic lesions: findings at proton MR spectroscopic imaging. Gynecol Obstet Invest 2005;60:121-127 https://doi.org/10.1159/000086003
  21. Hascalik S, Celik O, Erdem G. Magnetic resonance spectral analysis of ovarian teratomas. Int J Gynaecol Obstet 2005;90:152-154 https://doi.org/10.1016/j.ijgo.2005.02.021
  22. Woodward PJ, Sohaey R, Mezzetti TP, Jr. Endometriosis: radiologic-pathologic correlation. Radiographics 2001;21:193- 216;questionnaire 288-294 https://doi.org/10.1148/radiographics.21.1.g01ja14193
  23. Bis KG, Vrachliotis TG, Agrawal R, et al. Pelvic endometriosis: MR imaging spectrum with laparoscopic correlation and diagnostic pitfalls. Radiographics 1997;17:639-655 https://doi.org/10.1148/radiographics.17.3.9153703
  24. Ha HK, Lim GY, Cha ES, et al. MR imaging of tubo-ovarian abscess. Acta Radiol 1995;36:510-514 https://doi.org/10.3109/02841859509173418
  25. Gotsis ED, Fountas K, Kapsalaki E, et al. In vivo proton MR spectroscopy: the diagnostic possibilities of lipid resonances in brain tumors. Anticancer Res 1996;16:1565-1567
  26. Lai PH, Li KT, Hsu SS, et al. Pyogenic brain abscess: findings from in vivo 1.5-T and 11.7-T in vitro proton MR spectroscopy. AJNR Am J Neuroradiol 2005;26:279-288
  27. Pinero-Sagredo E, Nunes S, de Los Santos MJ, Celda B, Esteve V. NMR metabolic profile of human follicular fluid. NMR Biomed 2010;23:485-495 https://doi.org/10.1002/nbm.1488

Cited by

  1. Iterative averaging of spectra as a powerful way of suppressing spurious resonances in signal processing vol.55, pp.1, 2017, https://doi.org/10.1007/s10910-016-0693-9
  2. In vivo magnetic resonance spectroscopy for ovarian cancer diagnostics: quantification by the fast Padé transform vol.55, pp.1, 2013, https://doi.org/10.1007/s10910-016-0694-8
  3. Synergism of spectra averaging and extrapolation for quantification of in vivo MRS time signals encoded from the ovary vol.55, pp.5, 2017, https://doi.org/10.1007/s10910-016-0728-2
  4. Encoded in vivo time signals from the ovary in magnetic resonance spectroscopy: poles and zeros as the cornerstone for stability of response functions of systems to external perturbations vol.55, pp.5, 2013, https://doi.org/10.1007/s10910-017-0743-y
  5. Proton MR spectroscopy and the detection of malignancy in ovarian masses vol.92, pp.1101, 2013, https://doi.org/10.1259/bjr.20190134
  6. Magnetic Resonance Spectroscopy for Risk Stratification of Sonographically Indeterminate Ovarian Neoplasms: Preliminary Study vol.11, pp.10, 2013, https://doi.org/10.3390/diagnostics11101847