Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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An Efficient Synthesis of Substituted Furans by Cupric Halide-Mediated Intramolecular Halocyclization of 2-(1-Alkynyl)-2-alken-1-ones

  • Fu, Wei-Jun (College of Chemistry and Chemical Engineering, Luoyang Normal University) ;
  • Xu, Feng-Juan (Chemistry Department, Zhengzhou University) ;
  • Guo, Wen-Bo (College of Chemistry and Chemical Engineering, Luoyang Normal University) ;
  • Zhu, Mei (College of Chemistry and Chemical Engineering, Luoyang Normal University) ;
  • Xu, Chen (College of Chemistry and Chemical Engineering, Luoyang Normal University)
  • Received : 2012.10.16
  • Accepted : 2012.12.25
  • Published : 2013.03.20
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Abstract

An efficient synthesis of 3-halofurans by the intramolecular cyclization of 2-(1-alkynyl)-2-alken-1-ones with cupric halide has been developed. A broad range of 3-chloro- and 3-bromofuran derivatives could be obtained in the present method in moderate to good yields. The 3-halofuran derivatives are potential synthetic intermediates for amplification of molecular complexity.

Keywords

References

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