Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
권호 표지
DOI QR코드

DOI QR Code

Characteristics and Hair Growth Efficacy of Water Dissolving Micro-needles Containing Minoxidil Regarding Length of Micro-needles

미녹시딜을 내포한 용융형 고분자 마이크로 니들의 길이에 따른 특성 및 발모 효능 관찰

  • Received : 2013.01.02
  • Accepted : 2013.01.20
  • Published : 2013.05.25
Download PDF
⟨ Previous Next ⟩

Abstract

Two types of polymeric micro-needles with 250 and $750{\mu}m$ lengths were prepared by a micromolding process. The geometry of dissolving micro-needles with minoxidil was investigated and the mechanical property of polymer micro-needles was also evaluated. Water dissolving micro-needles containing minoxidil were successfully inserted into skin and delivered minoxidil to the skin layer after 30 min of insertion. The observed hair growth was less when the minoxidil treatment was not applied or used without the micro-needles than that the minoxidil was applied by micro-needles. Histologically, these hair follicles became bigger, and the hair papillae were totally encircled by the hair bulbs. In this feasibility test, we show the successful delivery of minoxidil, and effective treatment of hair loss can be possible by using dissolving micro-needles with minoxidil.

본 실험에선 미녹시딜을 함유한 수용성 고분자 젤로부터 solvent casting 방법으로 250과 $750{\mu}m$ 두 가지 길이의 미녹시딜이 함유된 용융형 고분자 마이크로 니들(micro-needle)을 제작하였다. 제작된 미녹시딜을 함유한 용융형 고분자 마이크로 니들은 기계적 강도가 입증된 고분자 니들과 동일한 형태 및 기계적 강도를 나타냈으며, 성공적으로 피부를 투과함을 확인하였다. 제조된 고분자 마이크로 니들의 경우 피부 적용 후 최소 30분 이상은 부착되어야 전체 니들의 50% (v/v) 이상이 피부 내로 용융되었으며, 니들 적용부위에서 서서히 약물의 방출 및 확산을 확인할 수 있었다. 또한 C57BL/6 동물 모델을 통해 미녹시딜이 함유된 250, $750{\mu}m$ 길이의 고분자 마이크로 니들이 무처리군 혹은 미녹시딜 처리군에 비해 발모에 긍정적인 영향을 나타냄을 확인할 수 있었다.

Keywords

Acknowledgement

Supported by : 경기도지역협력연구센터(GRRC)

References

  1. K. McElwee, D. Tobin, J. C. Bystryn, L. King, and J. Sundberg, Exp. Dermatol., 8, 371-379 (2007).
  2. D. Wasserman, D. A. Guzman-Sanchez, K. Scott, and A. McMichael, Int. J. Dermatol., 46, 121 (2007). https://doi.org/10.1111/j.1365-4632.2007.03193.x
  3. A. Gilhar and R. S. Kalish, Autoimmun. Rev., 5, 64 (2006). https://doi.org/10.1016/j.autrev.2005.07.001
  4. N. Al-Mutairi, Dermatol. Surg., 33, 1483 (2007). https://doi.org/10.1097/00042728-200712000-00011
  5. M. Waiz, A. Z. Saleh, R. Hayani, and S. O. Jubory, J. Cosmet. Laser Ther., 8, 27 (2006). https://doi.org/10.1080/14764170600607368
  6. E. A. Olsen, F. E. Dunlap, T. Funicella, J. A. Koperski, J. M. Swinehart, E. H. Tschen, and R. J. Trancik, J. Am. Acad. Dermatol., 47, 377 (2002). https://doi.org/10.1067/mjd.2002.124088
  7. A. W. Lucky, D. J. Piacquadio, C. M. Ditre, F. Dunlap, I. Kantor, A. G. Pandya, R. C. Savin, and M. D. Tharp, J. Am. Acad. Dermatol., 50, 541 (2004). https://doi.org/10.1016/j.jaad.2003.06.014
  8. D. A. Nelson and R. L. Spielvogel, Int. J. Dermatol., 24, 606 (2007).
  9. J. L. Italia, V. Bhardwaj, and M. R. Kumar, Drug Discov. Today, 11, 846 (2006). https://doi.org/10.1016/j.drudis.2006.07.015
  10. Y. K. Sung, S. Y. Hwang, S. Y. Cha, S. R. Kim, S. Y. Park, M. K. Kim, and J. C. Kim, J. Dermatol. Sci., 41, 150 (2006). https://doi.org/10.1016/j.jdermsci.2005.11.010
  11. T. Fischer, U. Hipler, and P. Elsner, Int. J. Dermatol., 46, 27 (2007).
  12. N. Otberg, A. Teichmann, U. Rasuljev, R. Sinkgraven, W. Sterry, and J. Lademann, Skin Pharmacol. Phys., 20, 195 (2007). https://doi.org/10.1159/000101389
  13. E. A. Olsen, A. G. Messenger, J. Shapiro, W. F. Bergfeld, M. K. Hordinsky, J. L. Roberts, D. Stough, K. Washenik, and D. A. Whiting, J. Am. Acad. Dermatol., 52, 301 (2005). https://doi.org/10.1016/j.jaad.2004.04.008
  14. S. Mura, F. Pirot, M. Manconi, F. Falson, and A. M. Fadda, J. Drug Target., 15, 101 (2007). https://doi.org/10.1080/10611860600991993
  15. Y. B. Lee, Y. S. Eun, J. H. Lee, M. S. Cheon, Y. G. Park, B. K. Cho, and H. J. Park, The Journal of Dermatology, 40, 81 (2013). https://doi.org/10.1111/j.1346-8138.2012.01680.x
  16. J. H. Park, S. O. Choi, S. Seo, Y. B. Choy, and M. R. Prausnitz, Eur. J. Pharm. Biopharm., 76, 282 (2010). https://doi.org/10.1016/j.ejpb.2010.07.001
  17. J. W. Lee, M. R. Han, and J. H. Park, Journal of Drug Targeting, DOI: 10.3109/1061186X.2012.741136 (2013).
  18. C. S. Kolli and A. K. Banga, Pharm. Res., 25, 104 (2008). https://doi.org/10.1007/s11095-007-9350-0
  19. G. Li, A. Badkar, S. Nema, C. S. Kolli, and A. K. Banga, Int. J. Pharmaceut., 368, 109 (2009). https://doi.org/10.1016/j.ijpharm.2008.10.008
  20. Y. Ito, A. Murakami, T. Maeda, N. Sugioka, and K. Takada, Int. J. Pharmaceut., 349, 124 (2008). https://doi.org/10.1016/j.ijpharm.2007.07.036
  21. J. W. Lee, S. O. Choi, E. I. Felner, and M. R. Prausnitz, Small, 7, 531 (2011). https://doi.org/10.1002/smll.201001091
  22. K. Matsuo, S. Hirobe, Y. Yokota, Y. Ayabe, M. Seto, Y. S. Quan, F. Kamiyama, T. Tougan, T. Horii, and Y. Mukai, J. Control. Release, 160, 495 (2012). https://doi.org/10.1016/j.jconrel.2012.04.001
  23. S. Kommareddy, B. C. Baudner, S. Oh, S. Kwon, M. Singh, and D. T. O'hagan, J. Pharm. Sci., 101, 1021 (2012). https://doi.org/10.1002/jps.23019
  24. J. W. Lee, J. H. Park, and M. R. Prausnitz, Biomaterials, 29, 2113 (2008). https://doi.org/10.1016/j.biomaterials.2007.12.048
  25. M. Y. Kim, B. Jung, and J. H. Park, Biomaterials, 33, 668 (2011).

Cited by

  1. 경제적이고 효과적인 경피 약물전달을 위한 3차원 구조의 코팅 고분자 마이크로니들 vol.38, pp.3, 2014, https://doi.org/10.7317/pk.2014.38.3.391