Biological Potential of Enzymatic and Polyphenol Extracts from Ecklonia cava

감태 효소 추출물 및 폴리페놀 추출물의 생리활성에 관한 연구

  • Lee, Su Min (R&D Center of Skin Science and Cosmetics, Enprani Co. Ltd.) ;
  • Kim, Jin Eun (R&D Center of Skin Science and Cosmetics, Enprani Co. Ltd.) ;
  • Oh, Myoung Jin (R&D Center of Skin Science and Cosmetics, Enprani Co. Ltd.) ;
  • Lee, Joo Dong (R&D Center of Skin Science and Cosmetics, Enprani Co. Ltd.) ;
  • Jeon, You-Jin (Department of Marine Life Science, Jeju National University) ;
  • Kim, Bora (R&D Center of Skin Science and Cosmetics, Enprani Co. Ltd.)
  • 이수민 (엔프라니(주) 피부과학연구소) ;
  • 김진은 (엔프라니(주) 피부과학연구소) ;
  • 오명진 (엔프라니(주) 피부과학연구소) ;
  • 이주동 (엔프라니(주) 피부과학연구소) ;
  • 전유진 (제주대학교 해양과학대학 해양의생명과학부) ;
  • 김보라 (엔프라니(주) 피부과학연구소)
  • Received : 2012.07.17
  • Accepted : 2013.01.17
  • Published : 2013.03.31


To investigate the efficacy of enzymatic extract of Ecklonia cava and its polyphenol extract (AG-DK) as cosmetic ingredients, the anti-oxidative effect, anti-glycation effect, anti-melanogenic effect, and anti-inflammatory effect of the extracts were evaluated in vitro. The enzymatic extract of E. cava ($SC_{50}$ 42.9 ppm) and AG-DK ($SC_{50}$ 6.4 ppm) showed a strong DPPH free radical scavenging activity. The anti-glycation ability of the enzymatic extract of E. cava and AG-DK was tested using bovine serum albumin (BSA), which inhibited the formation of advanced glycation end-products (AGEs) in the BSA/glucose system. The enzymatic extract of E. cava ($IC_{50}$ 97.2 ppm) and AG-DK ($IC_{50}$ 7 ppm) had inhibitory effects on tyrosinase activity. Moreover, the enzymatic extract of E. cava and AG-DK had an anti-inflammatory effect through the inhibition of nitricoxide (NO) and prostaglandin E2 ($PGE_2$). These findings suggest that the enzymatic extract of E. cava and AG-DK can be applied to skin-care products as cosmetic ingredients.

본 연구에서는 감태 효소 추출물과 그것의 폴리페놀 추출물의 화장품 원료로서의 효능을 알아보기 위하여 항산화, 항당화, 미백, 항염 효과와 관련된 실험을 실시하였다. 감태 효소 추출물과 폴리페놀 추출물은 강력한 라디컬 소거능을 가지고 있으며 BSA/Glucose 시스템에서 최종당화생성물의 형성을 저해하는 항당화 활성과 타이로시네이즈 저해를 통한 우수한 미백력을 가지고 있음을 확인하였다. 또한 두 추출물 모두 세포 내에서 $PGE_2$와 NO 생성 저해를 통한 항염 효과를 나타내었다. 이러한 결과를 종합해 볼 때, 감태 효소 추출물과 그 폴리페놀 추출물은 화장품 원료로서의 응용 가능성이 있을 것으로 사료된다.



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