Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Evaluation of the Antioxidant Activity and Anti-Inflammatory Effect of Hericium erinaceus Water Extracts

노루궁뎅이 버섯 열수추출물의 항산화 활성과 항염증 효능 평가

  • Kim, Da Hye (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University) ;
  • Park, Sa Ra (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University) ;
  • Debnath, Trishina (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University) ;
  • Hasnat, Md. Abul (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University) ;
  • Pervin, Mehnaz (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University) ;
  • Lim, Beong Ou (College of Biomedical & Health Science, Department of Applied Biochemistry, Konkuk University)
  • 김다혜 (건국대학교 의료생명대학 응용생화학 전공) ;
  • 박사라 (건국대학교 의료생명대학 응용생화학 전공) ;
  • 트리쉬나 (건국대학교 의료생명대학 응용생화학 전공) ;
  • 하스낫 (건국대학교 의료생명대학 응용생화학 전공) ;
  • 펄빈 (건국대학교 의료생명대학 응용생화학 전공) ;
  • 임병우 (건국대학교 의료생명대학 응용생화학 전공)
  • Received : 2013.01.18
  • Accepted : 2013.03.18
  • Published : 2013.04.30
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Abstract

This study was conducted to determine the antioxidative activity of Hericium erinaceus (HE) and we investigated that HE extract contributes to cell proliferation and to anti-LPS-induced inflammation. HE extract showed high DPPH free radical scavenging activity. However, the reducing power activity slightly increased in compare with control. Nitrite scavenging activity, ABTS radical scavenging activity, SOD-like activity of HE were elevated in dose-dependent. The level of total phenolic and flavonoid showed 30.06 mg/100 g and 33.86 mg/100 g, respectively. Linoleic acid oxidation inhibition had reached a maximum level on the fourth day and started to drop from the fifth day. HE extract contributes to cell proliferation on the RAW 264.7 cell. Our finding demonstrated that water extracts of HE possess significant antioxidant activities and may be suggested a new potential source of anti-inflammatory medicines.

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References

  1. Ahn DK. (1992). Medicinal fungi in Korea. Korean Journal of Mycology. 20:154-159.
  2. Blois MA. (1958). Antioxidant determination by the use of a stable free radical. Nature. 181:1199-1200. https://doi.org/10.1038/1811199a0
  3. Borrello S, Seccia A, Galeotti T, Bartoli GM, Farallo E and Serri F. (1984). Protective enzymes in human epidermal carcinomas and psoriasis. Archives of Dermatol Research. 276:338-340. https://doi.org/10.1007/BF00404630
  4. Chang HY and Roh MG. (1999). Physiological characteristics of Hericium erinaceus in sawdust media. Korean Journal of Mycology. 27:252-255.
  5. Cutler RG. (1984). Antioxidants aging, and longevity. In Pryor WA. (ed.). Free Radicals in Biology. Academic Press. New York. New York, USA. p.371-428.
  6. Debnath T, Bak JP, Samad NB, Jin HL, Lee BR and Lim BO. (2012). Antioxidant activity of mume fructus extract. Journal of Food Biochemistry. 36:224-232. https://doi.org/10.1111/j.1745-4514.2010.00529.x
  7. Franz H, Suganuma M, Okabe S, Sueoka N, Kozu T and Sakai Y. (1996). Japanese green tea as a cancer preventive in humans. Nutrition Reviews. 54:56-70.
  8. Gray JI and Dugan JRL. (1975). Inhibition of N-nitrosamine formation in model food system. Journal of Food Science. 40:981-985. https://doi.org/10.1111/j.1365-2621.1975.tb02248.x
  9. Ha JH, Jeong MH, Seo YC, Yong CW, Kim JS, Kim HH, Ahn JH and Lee HY. (2010). Enhancement of antioxidant activities of bark of Berberis koreana Palibin by lactic acid fermentation. Korean Journal of Medicinal Crop Science. 18:421-428.
  10. Jeong CH, Choi GN, Kim JH, Kwak JH, Heo HJ, Shim KH, Cho BR, Bae YII and Choi JS. (2009). In vitro antioxidant activities and phenolic composition of hot water extract from different parts of Cudrania tricuspidata. Journal of food science nutrition. 14:283-289. https://doi.org/10.3746/jfn.2009.14.4.283
  11. Jeong EJ, Sung SH, Kim J, Kim SH and Kim YC. (2008). Rhus verniciflua stokes attenuates glutamate-induced neurotoxicity in primary cultures of rat cortical cells. Natural Product Sciences. 14:156-160.
  12. Ji LL. (1993). Antioxidant enzyme response to exercise and aging. Medicine and Science in Spots and Exercise. 25:225-231.
  13. Jung GT, Ju IO, Choi JS and Hong JS. (2000). The antioxidative, antimicrobial and nitrite svcevenging effects of Schizandra chinensis(Omija) seed. Korean Journal of Food Science and Technology. 32:28-945.
  14. Kawagishi H, Shimada A, Hosokawa S, Mori H, Sakamoto H, Ishiguro Y, Sakemi S, Bordner J, Kojima N and Furukawa S. (1996). Erinacines E, F and G stimulators of nerve growth facoer(NGF)-synthesis from the mycelia of Hericium erinaceum. Tetrahedron Letters. 37:7399-7402. https://doi.org/10.1016/0040-4039(96)01687-5
  15. Lee JS and Lee JS. (2007). Physological function and develoment of beverage from Grifola frondosa. Journal of the Korean Society of Food Science and Nutrition. 36:1241-1247. https://doi.org/10.3746/jkfn.2007.36.10.1241
  16. Lee KA, Jung JE and Choi . (2007). Optimization of microwaveassisted extraction process of Hericium erinaceus. Korean Society for Food Engineering. 11:195-202.
  17. Lee YM, Bae JH, Jung HY, Kim JH and Park DS. (2011). Antioxidant activity in water and methanol extracts from Korean edible wild plants. Journal of the Korean Society of Food Science and Nutrition. 40:29-36. https://doi.org/10.3746/jkfn.2011.40.1.029
  18. Marklund S and Marklund G. (1975). Involvement of the superoxide anion radical in the oxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Herbology. 23:1-8.
  19. Myung JE and Hwang IK. (2008). Functional components and antioxidative activities of soybean extracts. Korea Soybean Digest. 25:23-29.
  20. Nieva Moreno MI, Isla MI, Sampietro AR and Vattuone MA. (2000). Comparision of the free radical -scavenging activity of propolis from several regions of Argentina. Journal of Ethnopahrmacology. 71:109-114. https://doi.org/10.1016/S0378-8741(99)00189-0
  21. Oyaizu M. (1986). Studies on products of browning reaction: antioxidant activities of products of browning reaction prepared from glucosamine. Japanese Journal of Nutrition. 44:307-315. https://doi.org/10.5264/eiyogakuzashi.44.307
  22. Papa S and Skulachev VP. (1997). Reactive oxygen species, mitochondria, apoptosis and aging. Molecular and Cellular Biochemistry. 174:305-319. https://doi.org/10.1023/A:1006873518427
  23. Song CH, Seo YC, Choi WY, Lee CG, Kim DU, Chung JY, Chung HC, Park DS, Ma CJ and Lee HY. (2012). Enhancement of antioxidant activity of Codonopsis lanceolata by stepwise steaming process. Korean Journal of Medicinal Crop Science. 20:238-244. https://doi.org/10.7783/KJMCS.2012.20.4.238
  24. Wang XJ, Sun H and Liu ZS. (1994). Quantitative analysis of 6,7-dimethylesculetin and capillarsine in Artemisia capillaries Thumb. and prescriptions containing the crude drug. China Journal of Chinese Materia Medica. 19:667-670.
  25. Yanmaguchi M and Yearul KA. (1987). Effect of shitake and maitake mushroom on blood pressure and plasma lipids of spontaneously hypertensive rats. Journal of Nutritional Science and Vitaminology. 33:341-345. https://doi.org/10.3177/jnsv.33.341
  26. Yearul KA and Shuichi K. (1989). Dietary mushroom reduce blood pressure in spontaneously hypertensive rat(SHR). Journal of Nutritional Science and Vitaminology. 35:91-94. https://doi.org/10.3177/jnsv.35.91

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