DOI QR코드

DOI QR Code

Link between Periodontal Disease and Cancer: A Recent Research Trend

염증-치주 질환과 암에 관한 최근 연구 동향

  • Lee, Shin Hwa (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) ;
  • Choi, Yung Hyun (Department of Biochemistry, Dongeui University College of Oriental Medicine, Blue-Bio Industry RIC & Anti-Aging Research Center, Dongeui University)
  • 이신화 (한국과학기술원 생명과학기술대학 생명과학과) ;
  • 최영현 (동의대학교 한의과대학 생화학교실 및 항노화연구소)
  • Received : 2013.03.09
  • Accepted : 2013.04.17
  • Published : 2013.04.30

Abstract

The multifaceted role of chronic inflammation in multistep carcinogenesis has been extensively investigated and well documented. Periodontal diseases are associated with multifactorial agents, including bacterial endotoxins and the generation of an inflammatory response, indicating that poor oral health is associated with a variety of systemic diseases. The association between poor oral health, chronic inflammation, smoking, and increased alcohol consumption as risk factors for tumorogenesis is well established. More recently, associations between oral health and tooth loss and gastric, lung, and pancreatic cancers have been explored, with some studies pointing to smoking and oral health as a common link with an increased risk for malignant disease. In addition, epidemiological studies consistently indicate increased risks of various cancers with periodontal disease or poor oral condition caused by oral bacteria, which may activate alcohol- and smoking-related carcinogens locally or act through chronic inflammation. Appropriate oral care is vital in preventing cancer, as well as many other diseases. Thus, research on the correlation between oral care and periodontal inflammation and cancer is required. This review highlights the association between oral health and the risk of certain malignancies, such as periodontal disease-associated chemoprevention of inflammation" in this sentence.

만성적인 염증이 다단계 발암과정에서 다면적인 역할을 하고 있음은 이미 잘 알려진 사실이다. 치주 질환의 원인은 구강 박테리아에서 분비되는 내독소들과 염증 유발인자들의 생성 등이 관여하는 다양한 요인들을 포함하며, 이는 잘못된 구강 위생 관리가 신체의 여러 가지 전신병적 원인과 연관되어 있음을 의미한다. 비위생적인 구강 상태와 연관된 만성 염증, 흡연, 알콜 섭취의 증가 등은 암의 발병 위험 요소로 작용함은 명확한 사실이다. 최근에는 구강 위생과 치아 손실이 위장관암, 폐암 및 췌장암 뿐만 아니라 혈구암 발병 증가와 직접적인 연관성이 있음이 밝혀졌다. 또한 흡연은 악성 질환 발병의 위험 요소로서 구강 위생의 강력한 위해요인임은 명백하며, 역학적 조사결과들에 의하면 구강 박테리아에 의한 치주 질환은 만성 염증을 통하여 흡연과 알콜 연관 발암원을 활성시킴으로서 다양한 암의 발병 위험 요소를 증가시킬 수 있는 것으로 나타났다. 따라서 암 뿐만 아니라 다른 다양한 질환의 예방을 위한 적절한 구강 관리는 필수적이다. 본 논문에서는 암예방을 위한 악성질환의 위해 요소로서 염증과 치주질환 및 구강 위생과의 연관성을 논하였다.

Keywords

References

  1. Abnet, C. C., Kamangar, F., Dawsey, S. M., Stolzenberg- Solomon, R. Z., Albanes, D., Pietinen, P., Virtamo, J. and Taylor, P. R. 2005. Tooth loss is associated with increased risk of gastric non-cardia adenocarcinoma in a cohort of Finnish smokers. Scand J Gastroenterol 40, 681-687. https://doi.org/10.1080/00365520510015430
  2. Abnet, C. C., Qiao, Y. L., Dawsey, S. M., Dong, Z. W., Taylor, P. R. and Mark, S. D. 2005. Tooth loss is associated with increased risk of total death and death from upper gastrointestinal cancer, heart disease, and stroke in a Chinese population-based cohort. Int J Epidemiol 34, 467-474. https://doi.org/10.1093/ije/dyh375
  3. Abnet, C. C., Qiao, Y. L., Mark, S. D., Dong, Z.W., Taylor, P.R. and Dawsey, S. M. 2001. Prospective study of tooth loss and incident esophageal and gastric cancers in China. Cancer Causes Control 12, 847-854. https://doi.org/10.1023/A:1012290009545
  4. Albandar, J. M., Brunelle, J. A. and Kingman, A. 1999. Destructive periodontal disease in adults 30 years of age and older in the United States, 1988-1994. J Periodontol 70, 13-29 https://doi.org/10.1902/jop.1999.70.1.13
  5. Amabile, N., Susini, G., Pettenati-Soubayroux, I., Bonello, L., Gil, J. M., Arques, S., Bonfil, J. J. and Paganelli, F. 2008. Severity of periodontal disease correlates to inflammatory systemic status and independently predicts the presence and angiographic extent of stable coronary artery disease. J Intern Med 263, 644-652. https://doi.org/10.1111/j.1365-2796.2007.01916.x
  6. Bundgaard, T., Wildt, J., Frydenberg, M., Elbrond, O. and Nielsen, J. E. 1995. Case-control study of squamous cell cancer of the oral cavity in Denmark. Cancer Causes Control 6, 57-67. https://doi.org/10.1007/BF00051681
  7. Cabrera, C., Hakeberg, M., Ahlqwist, M., Wedel, H., Bjorkelund, C., Bengtsson, C. and Lissner, L. 2005. Can the relation between tooth loss and chronic disease be explained by socio-economic status? A 24-year follow-up from the population study of women in Gothenburg, Sweden. Eur J Epidemiol 20, 229-236. https://doi.org/10.1007/s10654-004-5961-5
  8. Cochran, D. L. 2008. Inflammation and bone loss in periodontal disease. J Periodontol 79, S1569-1576. https://doi.org/10.1902/jop.2008.080233
  9. Cotran, R. S., Kumar, V.and Collins, T. 1999. Robbins Pathologic Basis of Disease. pp. 50-88, 260-327, 6th eds. WB Saunders Co., Philadelphia.
  10. Dye, B. A., Tan, S., Smith, V., Lewis, B. G., Barker, L. K., Thornton-Evans, G., Eke, P. I., Beltrán-Aguilar, E. D., Horowitz, A. M. and Li, C. H. 2007. Trends in oral health status: United States, 1988-1994 and 1999-2004. Vital Health Stat 11, 1-92.
  11. Flemmig, T. F. 1999. Periodontitis. Ann Periodontol 4, 32-38. https://doi.org/10.1902/annals.1999.4.1.32
  12. Garrote, L. F., Herrero, R., Reyes, R. M., Vaccarella, S., Anta, J. L., Ferbeye, L., Munoz, N. and Franceschi, S. 2001. Risk factors for cancer of the oral cavity and oro-pharynx in Cuba. Br J Cancer 85, 46-54. https://doi.org/10.1054/bjoc.2000.1825
  13. Grant, W. B. 2008. Vitamin D, periodontal disease, tooth loss, and cancer risk. Lancet Oncol 9, 612-613. https://doi.org/10.1016/S1470-2045(08)70164-5
  14. Hujoel, P. P., Drangsholt, M., Spiekerman, C. and Weiss, N. S. 2003. An exploration of the periodontitis-cancer association. Ann Epidemiol 13, 312-316. https://doi.org/10.1016/S1047-2797(02)00425-8
  15. Joshipura, K. J., Wand, H. C., Merchant, A. T. and Rimm, E. B. 2004. Periodontal disease and biomarkers related to cardiovascular disease. J. Dent. Res. 83, 151-155. https://doi.org/10.1177/154405910408300213
  16. Loe, H. and Brown, L. J. 1991. Early onset periodontitis in the United States of America. J Periodontol 62, 608-616. https://doi.org/10.1902/jop.1991.62.10.608
  17. Loos, B. G. 2005. Systemic markers of inflammation in periodontitis. J Periodontol 76, S2106-2115. https://doi.org/10.1902/jop.2005.76.11-S.2106
  18. Marshall, J. R., Graham, S., Haughey, B. P., Shedd, D., O'Shea, R., Brasure, J., Wilkinson, G. S. and West, D. 1992. Smoking, alcohol, dentition and diet in the epidemiology of oral cancer. Eur J Cancer B Oral Oncol 28B, 9-15.
  19. Mealey, B. L. and Rose, L. F. 2008. Diabetes mellitus and inflammatory periodontal diseases. Compend Contin Educ Dent 29, 402-408, 410, 412-413.
  20. Melvin, W. L., Sandifer, J. B. and Gray, J. L. 1991. The prevalence and sex ratio of juvenile periodontitis in a young racially mixed population. J Periodontol 62, 330-334. https://doi.org/10.1902/jop.1991.62.5.330
  21. Meyer, M. S., Joshipura, K., Giovannucci, E. and Michaud, D. S. 2008. A review of the relationship between tooth loss, periodontal disease, and cancer. Cancer Causes Control 19, 895-907. https://doi.org/10.1007/s10552-008-9163-4
  22. Michaud, D. S., Joshipura, K., Giovannucci, E. and Fuchs, C. S. 2007. A prospective study of periodontal disease and pancreatic cancer in US male health professionals. J Natl Cancer Inst 99, 171-175. https://doi.org/10.1093/jnci/djk021
  23. Persson, G. R. and Persson, R. E. 2008. Cardiovascular disease and periodontitis: an update on the associations and risk. J Clin Periodontol 35, S362-379. https://doi.org/10.1111/j.1600-051X.2008.01281.x
  24. Risch, H. A. 2003. Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. J Natl Cancer Inst 95, 948-960. https://doi.org/10.1093/jnci/95.13.948
  25. Rosenquist, K. 2005. Risk factors in oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden. Swed Dent J Suppl 179, 1-66.
  26. Stolzenberg-Solomon, R. Z., Dodd, K. W., Blaser, M. J., Virtamo, J., Taylor, P. R. and Albanes, D. 2003. Tooth loss, pancreatic cancer, and Helicobacter pylori. Am J Clin Nutr 78, 176-181.
  27. Talamini, R., Vaccarella, S., Barbone, F., Tavani, A., La Vecchia, C., Herrero, R., Muñoz, N. and Franceschi, S. 2000. Oral hygiene, dentition, sexual habits and risk of oral cancer. Br J Cancer 83, 1238-1242. https://doi.org/10.1054/bjoc.2000.1398
  28. Tu, Y. K., Galobardes, B., Smith, G. D., McCarron, P., Jeffreys, M. and Gilthorpe, M. S. 2007. Associations between tooth loss and mortality patterns in the Glasgow Alumni Cohort. Heart 93, 1098-1103. https://doi.org/10.1136/hrt.2006.097410
  29. van Kempen, L. C., de Visser, K. E. and Coussens, L. M. 2006. Inflammation, proteases and cancer. Eur J Cancer 42, 728-734. https://doi.org/10.1016/j.ejca.2006.01.004
  30. Watabe, K., Nishi, M., Miyake, H. and Hirata, K. 1998. Lifestyle and gastric cancer: a case-control study. Oncol Rep 5, 1191-1194.
  31. Zheng, T. Z., Boyle, P., Hu, H. F., Duan, J., Jian, P. J., Ma, D. Q., Shui, L. P., Niu, S. R., Scully, C. and MacMahon, B. 1990. Dentition, oral hygiene, and risk of oral cancer: a case-control study in Beijing, People's Republic of China. Cancer Causes Control 1, 235-241. https://doi.org/10.1007/BF00117475
  32. Zupan, J., Jeras, M. and Marc, J. 2013. Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclasts. Biochemia Medica 23, 43-63.

Cited by

  1. Relationship between cancer and oral health in Korean adults determined using data from the 6th (2013-2014) Korea National Health and Nutritional Examination Survey vol.41, pp.1, 2017, https://doi.org/10.11149/jkaoh.2017.41.1.16