Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Effects of Acupuncture at the River Points(LU8, HT4, PC5, SP5, KI7, LR4) on the Changes of Nitric Oxide Synthase and Norepinephrine in Rats

백서(白鼠)의 경혈(經穴)(LU8, SP5, HT4, KI7, PC5, LR4) 침자(針刺)가 Nitric Oxide Synthase 및 Norepinephrine의 변화에 미치는 영향(影響)

  • Kim, Youngsun (College of Oriental Medicine, Dongshin University) ;
  • Choi, Donghee (College of Oriental Medicine, Dongshin University) ;
  • Jang, Hosun (College of Oriental Medicine, Dongshin University) ;
  • Na, Changsu (College of Oriental Medicine, Dongshin University) ;
  • Shin, Heontae (College of Oriental Medicine, Dongshin University) ;
  • Cho, Joohyun (Biotechnology Industrialization Center, Dongshin University) ;
  • Lee, Kyoungin (Biotechnology Industrialization Center, Dongshin University) ;
  • Kim, Sunmin (Biotechnology Industrialization Center, Dongshin University) ;
  • Pyo, Byoungsik (Biotechnology Industrialization Center, Dongshin University) ;
  • Youn, Daehwan (College of Oriental Medicine, Dongshin University)
  • 김영선 (동신대학교 한의과대학) ;
  • 최동희 (동신대학교 한의과대학) ;
  • 장호선 (동신대학교 한의과대학) ;
  • 나창수 (동신대학교 한의과대학) ;
  • 신헌태 (동신대학교 한의과대학) ;
  • 조주현 (동신대학교 생물자원산업화지원센터) ;
  • 이경인 (동신대학교 생물자원산업화지원센터) ;
  • 김선민 (동신대학교 생물자원산업화지원센터) ;
  • 표병식 (동신대학교 생물자원산업화지원센터) ;
  • 윤대환 (동신대학교 한의과대학)
  • Received : 2012.12.26
  • Accepted : 2013.02.28
  • Published : 2013.03.27
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Abstract

Objectives : The Meridians and acupuncture points are the fundamental theories for acupuncture therapy. They have been associated with nervous system, but It is not well defined. We investigated that the effects of acupuncture at the river points(LU8, HT4, PC5, SP5, KI7, LR4) on the changes in the expression of nNOS, iNOS, eNOS, and NE in rats. Methods : The Male Sprague-Dawley rats were divided into 6 groups each non-acupuncture and acupuncture group. We inserted needle and retained for 5 minutes on both left and right sides of LU8, HT4, PC5, SP5, KI7, LR4 which were the river points of five transport points for 6 yin meridian vessels. After that, blood was drawn via cardiac puncture, and tissues for each point near meridian vessels were extracted to examine the changes in the changes of nNOS, eNOS, iNOS and NE. Results : The LU8 and HT4 group showed a significant decrease on nNOS. In terms of eNOS and iNOS, the LU8 group decreased significantly while the KI7 group increased significantly. However, the experimental groups didn't show any significant changes on the plasma and tissue norepinephrine without plama NE in SP5 group. Conclusions : The effect on the nNOS, iNOS, eNOS of acupuncture at LU8 and KI7 could be observed, and it is considered that the effect of acupuncture related with on nervous system could be studied by additional researches based on this one.

Keywords

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