Gold Beads Implants for The Treatment of Canine Chronic Recurrent Otitis Externa

  • Sumano, Hector (Department of Physiology & Pharmacology, School of Veteinary Medicine, National Autonomous University of Mexico) ;
  • Tapia-Perez, Graciela (Department of Statistics, School of Veteinary Medicine, National Autonomous University of Mexico) ;
  • Gutierrez, Lilia (Department of Physiology & Pharmacology, School of Veteinary Medicine, National Autonomous University of Mexico)
  • Accepted : 2013.03.22
  • Published : 2013.04.30

Abstract

A clinical trial was performed to assess clinical efficacy and/or reduction in relapses by gold-bead implantation into acupuncture points in dogs with canine chronic recurrent otitis externa (CCROE). Forty dog-patients randomly divided into two groups were diagnosed as suffering CCROE, having intact tympanic membranes and a history of recurrences. Treatments were: control group (CG), treated with commercially available antimicrobial otic droplets, dosed twice daily for 7 days; and experimental group (GBI- gold bead implants), treated as for CG plus the insertion of 13 gold-bead implants under light anesthesia. Overall per cent assessment of composite clinical progression and progression of individual clinical signs were recorded. Bilateral chronic external otitis was diagnosed in 60% of the cases and left or right otitis in 20% of the cases each. Logistic model for repeated measures analysis showed that GBI induced a better clinical recovery as far as lesion score of some clinical signs is concerned. The overall percent cures of each group showed statistically significant difference. A McNemar analysis revealed that higher number of relapses was observed in CG patients as compared to the GBI (P < 0.05). In particular during these days, lesion on the pinna showed in odd ratios analysis a 7:1 ratio (recurrence CG:GBI) and ear wax/pus (4:1) from D42 to D365. It is concluded that gold-bead implantation into acupuncture points improves resolution of some clinical signs and greatly reduce relapses in CCROE affected dogs after 1 year follow-up (98.75%).

Keywords

References

  1. Bolliger C, DeCamp CE, Stajich M, Gait, S. Analysis of dogs with hip dysplasia treated with gold bead implantation acupuncture. Vet Complement Orthop Traumatol 2002; 15: 116-122.
  2. Burmester GR. Molecular mechanism of action of gold treatment in rheumatoid arthritis: an update. Z Rheumatol 2001; 60: 167-173. https://doi.org/10.1007/s003930170065
  3. Cantwell SL. Traditional Chinese Veterinary Medicine: The Mechanism and Managent of Acupuncture for Chronic Pain. Top Companion Anim Med 2010; 25: 53-58. https://doi.org/10.1053/j.tcam.2009.10.006
  4. Cole L. Microbial flora and antimicrobial sensitivity patterns of isolated pathogens from the horizontal ear canal and middle ear in dogs with otitis media. J Am Vet Med Assoc 1998; 212: 534-538.
  5. Cole L. Otoscopic evaluation of the ear canal. Vet Clin North Am Small Anim Pract 2004; 34: 397-410. https://doi.org/10.1016/j.cvsm.2003.10.004
  6. Danscher G. In vivo liberation of gold ions from gold implants. Autometallographic tracing of gold in cells adjacent to metallic gold. Histochem Cell Biol 2002; 117: 447-452. https://doi.org/10.1007/s00418-002-0400-8
  7. Demann ET, Stein PS, Haubenreich JE. Gold as an implant in medicine and dentistry. J Long Term Eff Med Implants 2005; 15: 687-698. https://doi.org/10.1615/JLongTermEffMedImplants.v15.i6.100
  8. Durkes TE. Gold Bead Implants. In: Veterinary Acupuncture, Ancient Art to Modern Medicine 2nd ed. St Louis: Mosby. 2001: 303-305.
  9. Durkes TE. Gold bead implants. Probl Vet Med 1992; 4: 207-211.
  10. Goiz-Marquez G, Caballero S, Solis H, Rodriguez C, Sumano H. Electroencephalographic evaluation of gold wire implants inserted in acupuncture points in dogs with epileptic seizures. Res Vet Sci 2009; 86: 152-161. https://doi.org/10.1016/j.rvsc.2008.05.019
  11. Gotthelf L. Diagnosis and treatment of otitis media in dogs and cats. Vet Clin North Am Small Anim Pract 2004; 34: 469-478. https://doi.org/10.1016/j.cvsm.2003.10.007
  12. Gotthelf L. Secondary otitis media: An often overlooked condition. Canine Pract 1995; 20: 14-20.
  13. Graham GG. The activation of gold complexes by cyanide produced by polymorphonuclear leukocytes, the formation of aurocynide by myeloperoxidase. Biochem Pharmacol 1990; 39: 1697-1702. https://doi.org/10.1016/0006-2952(90)90113-Y
  14. Habacher G, Pittler MH, Edzard E. Effectiveness of acupuncture in veterinary medicine: systematic review. J Vet Intern Med 2008; 20: 480-488.
  15. Hielm-Bjorkman A, Raekallio M, Kuusela E, Saarto E, Markkola A, Tulamo RM. Double-blind evaluation of implants of gold wire at acupuncture points in the dog as a treatment for osteoarthritis induced by hip dysplasia. Vet Rec 2001; 149: 452-456. https://doi.org/10.1136/vr.149.15.452
  16. Jæger GT, Larsen S, Søli N, Moe L. Two years follow-up study of the pain-relieving effect of gold bead implantation in dogs with hip-joint arthritis. Acta Vet Scand 2007; 49: 9. https://doi.org/10.1186/1751-0147-49-9
  17. Kothbauer O, Steingassner M. Goldimplantationen: Ein elektrophysikalisches Phänomen zur Therapie von schmerzhaften Gelenkserkrankungen bei Tieren: -Auswertungen von Versuchsmessungen. Deut Zeitschrift Akupunktur 2010; 53: 54-58.
  18. Lanz OB, Wood BC. Surgery of the ear and pinna. Vet Clin North Am Small Anim Pract 2004; 34: 567-599. https://doi.org/10.1016/j.cvsm.2003.10.011
  19. Larsen A, Stoltenberg M, Danscher G. In vitro liberation of charged gold atoms: autometallographic tracing of gold ions released by macrophages grown on metallic gold surfaces. Histochem Cell Biol 2007; 128:1-6. https://doi.org/10.1007/s00418-007-0295-5
  20. Mangalam AK. Mechanism of action of disease modifying anti-rheumatic agent, gold sodium thiomalate. Int Immunopharmacol 2001; 1: 1165-1172. https://doi.org/10.1016/S1567-5769(01)00050-9
  21. Mason LK, Harvey CE, Orsher RJ. Total ear ablation combined with lateral bulla osteotomy for end-stage otitis in dogs. Vet Surg 1988; 17: 263-268. https://doi.org/10.1111/j.1532-950X.1988.tb01012.x
  22. Morris DO. Medical therapy of otitis externa and otitis media. Vet Clin North Am Small Anim Pract. 2004; 34: 541-555. https://doi.org/10.1016/j.cvsm.2003.10.009
  23. Murray PR Baron EJ Jorgensen JH. Manual of Clinical Microbiology, 8th ed. Washington DC: ASM Press, 2003: 3.
  24. Nejrup K, Olivarius NF, Jacobsen JL, Siersma V. Randomized controlled trial of extra-articular gold bead implantation for treatment of knee osteoarthritis: a pilot study. Clin Rheumatol 2007; 27: 1363-1369.
  25. Parsons N, Costa R, Matthew L, Achten J, Stallard N. Repeated measures proportional odds logistic regression analysis of ordinal score data in the statistical software package R. Computational Statistics & Data Analysis 2009; 53: 632-641. https://doi.org/10.1016/j.csda.2008.08.004
  26. R Development Core Team, 2010. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0. http://www.R-project.org.
  27. Robinson NG. Gold Bead Implants - Medicine or Malpractice?: 2008. http://csuvets.colostate.edu/pain/Articlespdf/Gold BeadImplants, pdf accessed 26 may 2010
  28. Rogers P. Serious complications of acupuncture-or acupuncture abuses? Am J Acupunct 1981; 9: 347-351.
  29. Romaguera C, Grimalt F. Contact dermatitis from a permanent acupuncture needle. Contact Dermatitis 1981; 81: 156-157.
  30. Rosser EJ. Causes of otitis externa. Vet Clin North Am Small Anim Pract 2004; 34: 459-468. https://doi.org/10.1016/j.cvsm.2003.10.006
  31. Sidrim JJC, Moreira JLB. Fundamentos clínicos e laboratoriais da micologia medica. 1. Rio de Janeiro; Guanabara Koogan S.A. 1999
  32. Takase K. Revolutionary new pain theory and acupuncture treatment procedure based on new theory of acupuncture mechanism. Am J Acupunct 1983; 11: 305-323.