Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
권호 표지

Ethosome Formulation for Enhanced Transdermal Delivery of Artemisia princeps Pampanini Extracts

사자발쑥 추출물의 피부 흡수 증진을 위한 에토좀 제형에 관한 연구

  • Yang, Hyun Gab (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Kim, Hye Jin (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Kim, Hae Soo (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Park, Soo Nam (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology)
  • 양현갑 (서울과학기술대학교 정밀화학과, 나노바이오화장품연구실, 화장품종합기술연구소) ;
  • 김혜진 (서울과학기술대학교 정밀화학과, 나노바이오화장품연구실, 화장품종합기술연구소) ;
  • 김해수 (서울과학기술대학교 정밀화학과, 나노바이오화장품연구실, 화장품종합기술연구소) ;
  • 박수남 (서울과학기술대학교 정밀화학과, 나노바이오화장품연구실, 화장품종합기술연구소)
  • Published : 2013.04.10
⟨ Previous Next ⟩

Abstract

In our previous studies, the antioxidant, anti-aging, and antibacterial activities of Artemisia princeps Pampnini (A. princeps Pamp.) extract were reported. In this study, ethosome formulations for the enhanced transdermal delivery of A. princeps Pamp. extract were prepared. The particle size, loading efficiency and skin permeation of them were evaluated. The ethosome loaded with 0.06% ethyl acetate fraction of A. princeps Pamp. extract was more stable and maintained the constant particle size for 3 weeks after being prepared. The particle size of ethosome containing 0.06% ethyl acetate fraction was $287.05{\pm}0.25nm$ and the loading efficiency was $51.96{\pm}0.01%$. The ethosome formulation exhibited the greater enhancement of skin permeation than of general liposome and 20% ethanol solution in skin permeability experiments.

이전 연구에서 저자들은 사자발쑥 추출물의 항산화, 항노화 및 항균활성에 대한 결과를 보고한 바 있다. 본 연구에서는 사자발쑥 추출물의 피부 전달시스템으로 에토좀을 제조하고 입자크기, 포집효율 및 피부 투과를 평가하였다. 0.06% 사자발쑥 추출물의 에틸아세테이트 분획을 담지한 에토좀은 3주 동안 보다 더 안정하였고 일정한 입자크기를 유지하였다. 0.06% 에틸아세테이트 분획을 함유한 에토좀의 입자 크기는 $287.05{\pm}0.25nm$, 포집효율은 $51.96{\pm}0.01%$였다. 피부 투과 실험 결과, 에토좀 제형은 일반 리포좀이나 20% 에탄올 용액에서 보다 큰 피부 투과능을 보여주었다.

Keywords

References

  1. H. J. Yang, Y. J. Ahn, J. H. Kim, and S. N. Park, J. Soc. Cosmet. Scientists Korea, 34, 189 (2008).
  2. S. N. Park, J. Korean Ind. Eng. Chem., 14, 657 (2003).
  3. Q. Chen, A. Fischer, J. D. Reagan, L. J. Yan, and B. N. Ames, Proc. Natl. Sci. USA, 92, 4337 (1995). https://doi.org/10.1073/pnas.92.10.4337
  4. J. E. Kim, K. Y. Chae, and S. N. Park, J. Soc. Cosmet. Scientists Korea, 37, 265 (2011).
  5. K. Scharffetter-Kochanek, Photoaging of the connective tissue of skin: Its prevention and therapy, In: Antioxidants in disease mechanisms and therapy, eds. H. Sies, Advances Pharmacology (1996).
  6. L. Packer, Utraviolet radiation (UVA, UVB) and skin antioxidants, In: Free radical damage and its control, eds. C. A. Rice-Evans and R. H. Burdon, Elsevier Science B.V. (1994).
  7. S. N. Park, J. Soc. Cosmet. Scienctists Korea, 23, 75 (1997).
  8. J. J. Thiele, C. O. Barland, R. Ghadially, and P. M. Elias, Permeability and antioxidant Barriers in aged epidermis, Skin Aging (B. A. Gilchrest, J. Krutman, eds), Springer-Verlag Berlin Heidelberg, Germany, 65 (2006).
  9. A. S. Michaels, S. K. Chandrasekaran, and J. E. Shaw, AlChE J., 21, 985 (1975). https://doi.org/10.1002/aic.690210522
  10. P. L. Honeywell-Nguyen and J. A. Bouwstra, Drug Discovery Today: Technologies., 2, 67 (2005). https://doi.org/10.1016/j.ddtec.2005.05.003
  11. B. S. Jin, Y. M. Han, K. H. Lee, and M. J. Choi, J. Korean Ind. Eng. Chem., 15, 205 (2004).
  12. M. M. A. Elsayed, O. Y. Abdallah, V. F. Naggar, and N. M. Khalafallah, Int. J. Pharm, 332, 1 (2007). https://doi.org/10.1016/j.ijpharm.2006.12.005
  13. E. Touitou, N. Dayan, L. Bergelson, B. Godin, and M. Eliaz, J. Control. Release, 65, 403 (2000). https://doi.org/10.1016/S0168-3659(99)00222-9
  14. H. J. Gwak and B. S. Jin, J. Korean Ind. Eng. Chem., 18, 130 (2007).
  15. V. Dubey, D. Mishra, T. Dutta, M. Nahar, D. K. Saraf, and N. K. Jain, J. Control. Release, 123, 148 (2007). https://doi.org/10.1016/j.jconrel.2007.08.005
  16. V. Dubey, D. Mishra, and N. K. Jain, Eur. J. Pharm. Biopharm., 67, 398 (2007). https://doi.org/10.1016/j.ejpb.2007.03.007
  17. T. Adachi, H. Takahashi, K. Ohki, and I. Hatta, Biophysical J., 68, 1850 (1995). https://doi.org/10.1016/S0006-3495(95)80361-9
  18. M. H. Bang, J. G. Cho, M. C. Song, D. Y. Lee, M. W. Han, H. G. Chung, T. S. Jeong, K. T. Lee, M. S. Choi, and N. I. Baek, J. Korean Soc. Appl. Biol. Chem., 51, 223 (2008).
  19. M. H. Bang, D. H. Kim, J. S. Yoo, D. Y. Lee, M. C. Song, H. J. Yang, T. S. Jeong, K. T. Lee, M. S. Choi, H. G. Chung, and N. I. Baek, J. Kor. Soc. Appl. Biol. Chem., 48, 418 (2005).
  20. J. S. Yoo, E. M. Ahn, M. H. Bang, M. C. Song, H. J. Yang, D. H. Kim, D. Y. Lee, H. G. Chung, T. S. Jeong, K. T. Lee, M. S. Choi, and N. I. Baek, Kor. J. Medicinal. Crop. Sci., 14, 273 (2006).
  21. S. H. Chang, E. J. Jung, Y. H. Park, D. G. Lim, N. Y. Ko, W. S. Choi, E. Her, S. H. Kim, K. D. Choi, J. H. Bae, S. H. Kim, C. D. Kang, D. J. Han, and S. C. Kim, J. Pharm. Pharmacol., 61, 1043 (2009). https://doi.org/10.1211/jpp/61.08.0008
  22. U. J. Junga, N. I. Baek, H. G. Chung, M. H. Bang, J. S. Yoo, T. S. Jeong, K.T. Lee, Y. J. Kang, M. K. Lee, H. J. Kim, J. Y. Yeo, and M. S. Choi, Food Chem. Toxicol., 45, 2022 (2007). https://doi.org/10.1016/j.fct.2007.04.021
  23. H. G. Yang, H. J. Kim, H. S. Kim, and S. N. Park, Korean J. Microbiol. Biotechnol., 40, 250 (2012). https://doi.org/10.4014/kjmb.1207.07014
  24. Y. P. Fang, Y. H. Tsai, P. C. Wu, and Y. B. Huang, Int. J. Pharm., 356, 144 (2008). https://doi.org/10.1016/j.ijpharm.2008.01.020
  25. D. Paolino, G. Lucania, D. Mardente, F. Alhaique, and M. Fresta, J. Control. Release, 106, 99 (2005). https://doi.org/10.1016/j.jconrel.2005.04.007
  26. Y. P. Fang, Y. B. Huang, P. C. Wu, and Y. H. Tsai, Eur. J. Pharm. Biopharm., 73, 391 (2009). https://doi.org/10.1016/j.ejpb.2009.07.011