Korean Journal of Poultry Science (한국가금학회지)

The Korean Society of Poultry Science (한국가금학회)
권호 표지
DOI QR코드

DOI QR Code

FABP3 and FABP4 Genes Are the Potential Candidates for Body Weights in Korean Native Chicken

  • Cahyadi, Muhammad (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Seo, Dongwon (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Choi, Nuri (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Jin, Shil (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Maharani, Dyah (Faculty of Animal Science, Gadjah Mada University) ;
  • Heo, Kang Nyeong (Poultry Science Division, National Institute of Animal Science, RDA) ;
  • Kang, Bo Seok (Poultry Science Division, National Institute of Animal Science, RDA) ;
  • Jo, Cheorun (Department of Animal Science and Biotechnology, Chungnam National University) ;
  • Lee, Jun Heon (Department of Animal Science and Biotechnology, Chungnam National University)
  • Received : 2013.03.12
  • Accepted : 2013.05.07
  • Published : 2013.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

FABPs, 15 kDa organic substances, are small intracellular proteins which have a primary role to regulate fatty acid uptake and intracellular transport. This study was conducted to identify SNPs in the two FABP family genes and their associations with the body weight traits in Korean native chicken (KNC). Two SNPs, namely g.508C>T of FABP3 gene and g.285C>T of FABP4 gene, have been genotyped by using PCR-RFLP method. The results showed that FABP3 was significantly associated with body weight at birth, body weights at 12 to 20 weeks, and also slaughter weight. Moreover, the g.285C>T SNP of FABP4 gene was not associated with any body weight traits. These results suggested that the g.508C>T SNP of FABP3 genes can be used as molecular markers to select KNC having desirable body weights.

Keywords

References

  1. Agulleiro MJ, Andre M, Morais S, Cerda J, Babin PJ 2007 High transcript level of fatty acid-binding protein 11 but not of very low-density lipoprotein receptor is correlated to ovarian follicle atresia in a teleost fish (Solea senegalensis). Biol Reprod 77:504-516. https://doi.org/10.1095/biolreprod.107.061598
  2. Bai Y, Sun G, Kang X, Han R, Tian Y, Li H, Wei Y, Zhu S 2012 Polymorphisms of the pro-opiomelanocortin and agouti-related protein genes and their association with chicken production traits. Mol Biol Rep 39:7533-7539. https://doi.org/10.1007/s11033-012-1587-y
  3. Chen QM, Wang H, Zeng YQ, Chen W 2013 Developmental changes and effect on intramuscular fat content of HFABP and A-FABP mRNA expression in pigs. J Appl Genet 54:119-123. https://doi.org/10.1007/s13353-012-0122-0
  4. Chmurzynska A 2006 The multigene family of fatty acidbinding proteins (FABPs): function, structure and polymorphism. J Appl Genet 47:39-48. https://doi.org/10.1007/BF03194597
  5. Cho KH, Kim MJ, Jeon GJ, Chung HY 2011 Association of genetic variants for FABP3 gene with back fat thickness and intramuscular fat content in pig. Mol Biol Rep 38: 2161-2166. https://doi.org/10.1007/s11033-010-0344-3
  6. Corripio R, Gonzalez-Clemente JM, Perez-Sanchez J, Naf S, Gallart L, Nosas R, Vendrell J, Caixas A 2010 Weight loss in prepubertal obese children is associated with a decrease in adipocyte fatty-acid-binding protein without changes in lipocalin-2: a 2-year longitudinal study. Eur J Endocrinol 163:887-893. https://doi.org/10.1530/EJE-10-0408
  7. Dekkers JCM, Hospital F 2002 The use of molecular genetics in the improvement of agricultural populations. Nat Rev Genet 3:22-32. https://doi.org/10.1038/nrg701
  8. Engl J, Ciardi C, Tatarczyk T, Kaser S, Laimer M, Laimer E, Weiss H, Aigner F, Molnar C, Tilg H, Patsch JR, Ebenbichler CF 2008 A-FABP-a biomarker associated with the metabolic syndrome and/or an indicator of weight change? Obesity (Silver Spring) 16:1838-1842. https://doi.org/10.1038/oby.2008.273
  9. Falconer DS, Mackay TFC 1996 Introduction of Quantitative Genetics. 4th ed. Longman, Malaysia.
  10. Gardan D, Louveau I, Gondret F 2007 Adipocyte- and heart-type fatty acid binding proteins are both expressed in subcutaneous and intramuscular porcine Sus scrofa adipocytes. Comp Biochem Physiol B Biochem Mol Biol 148:14-19. https://doi.org/10.1016/j.cbpb.2007.03.017
  11. Heo KN, Choo HJ, Seo BY, Park MN, Jung KC, Hwangbo J, Kim HK, Hong EC, Seo OS, Kang BS 2011 Investigation of TYR and MC1R polymorphisms in Korean native chicken and commercial chickens. CNU J Agric Sci 38:465-471.
  12. Hoque MR, Lee SH, Jung KC, Kang BS, Park MN, Lim HK, Choi KD, Lee JH 2011 Discrimination of Korean native chicken populations using SNPs from mtDNA and MHC polymorphisms. Asian-Aust J Anim Sci 24:1637-1643. https://doi.org/10.5713/ajas.2011.11144
  13. Hoque MR, Lee SW, Lee JH 2012 DNA markers in chicken for breed discrimination. CNU J Agric Sci 39:208-214.
  14. Ikeobi CON, Woolliams JA, Morrice DR, Law A, Windsor D, Burt DW, Hocking PM 2004 Quantitative trait loci for meat yield and muscle distribution in a broiler layer cross. Livestock Prod Sci 87:143-151. https://doi.org/10.1016/j.livprodsci.2003.09.020
  15. Khalyfa A, Bhushan B, Hegazi M, Kim J, Kheirandish-Gozal L, Bhattacharjee R, Capdevila OS, Gozal D 2010 Fattyacid binding protein 4 gene variants and childhood obesity: Potential implications for insulin sensitivity and CRP levels. Lipids Health Dis 9:18-23. https://doi.org/10.1186/1476-511X-9-18
  16. Kusudo T, Kontani Y, Kataoka N, Ando F, Shimokata H, Yamashita H 2011 Fatty acid-binding protein 3 stimulates glucose uptake by facilitating AS160 phosphorylation in mouse muscle cells. Genes Cells 16: 681-691. https://doi.org/10.1111/j.1365-2443.2011.01517.x
  17. Li H, Wu G, Zhang J, Yang N 2010 Identification of the heart-type fatty acid-binding protein as a major gene for chicken fatty acid metabolism by Bayesian network analysis. Poultry Sci 89:8925-1833.
  18. Li WJ, Li HB, Chen JL, Zhao GP, Zheng MQ, Wen J 2008 Gene expression of heart- and adipocyte-fatty acid-binding protein and correlation with intramuscular fat in Chinese chickens. Anim Biotechnol 19:189-193.
  19. Maharani D, Park HB, Jung Y, Jung S, Jo C, Lee JH 2011 Investigation of SNPs in FABP3 and FABP4 genes and their possible relationships with fatty acid composition in broiler. Korean J Poult Sci 38:231-237. https://doi.org/10.5536/KJPS.2011.38.3.231
  20. Miller SA, Dykes DD, Polesky HF 1988 A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215. https://doi.org/10.1093/nar/16.3.1215
  21. Nassar MK, Goraga ZS, Brockmann GA 2012 Quantitative trait loci segregating in crosses between New Hampshire and White Leghorn chicken lines: II. Muscle weight and carcass composition. Anim Genet 43:739-745. https://doi.org/10.1111/j.1365-2052.2012.02344.x
  22. Reinehr T, Stoffel-Wagner B, Roth CL 2007 Adipocyte fatty acid-binding protein in obese children before and after weight loss. Metabolism 56:1735-1741. https://doi.org/10.1016/j.metabol.2007.07.019
  23. Sang BD, Hong SK, Kim HK, Choi CH, Kim SD, Cho YM, Sang BC, Lee JH, Jeon GJ, Lee HK 2006 Estimation of genetic parameters for economic traits in Korean native chickens. Asian-Aust J Anim Sci 19:319-323. https://doi.org/10.5713/ajas.2006.319
  24. Seo DW, Hoque MR, Choi NR, Sultana H, Park HB, Neo KN, Kang BS, Lim HT, Lee SH, Jo C, Lee JH 2013 Discrimination of Korean native chicken lines using fifteen selected microsatellite markers. Asian-Aust J Anim Sci 26:316-322. https://doi.org/10.5713/ajas.2012.12469
  25. Smathers RL, Petersen DR 2011 The human fatty acidbinding protein family: evolutionary divergences and functions. Human Genomics 5:170-191. https://doi.org/10.1186/1479-7364-5-3-170
  26. Wang Q, Guan T, Li H, Bernlohr DA 2009 A novel polymorphism in the chicken adipocyte fatty acid-binding protein gene (FABP4) that alters ligand-binding and correlates with fatness. Comp Biochem Physiol B Biochem Mol Biol 154:298-302. https://doi.org/10.1016/j.cbpb.2009.07.002
  27. Wang Q, Li H, Leng L, Wang Y, Tang Z, Li N, Zhang F 2007 Polymorphism of heart fatty acid-binding protein gene associatied with fatness traits in the chicken. Anim Biotechnol 18:91-99. https://doi.org/10.1080/10495390601038900
  28. Wang Q, Li H, Li N, Leng L, Wang Y, Tang Z 2006 Identification of single nucleotide polymorphism of adipocyte fatty acid-binding protein gene and its association with fatness traits in the chicken. Poultry Sci 85:429-434. https://doi.org/10.1093/ps/85.3.429
  29. Ye MH, Chen JL, Zhao GP, Zheng MQ, Wen J 2010 Associations of A-FABP and H-FABP markers with the content of intramuscular fat in Beijing-You chicken. Anim Biotechnol 21:14-24.
  30. You X, Liu Y, Jiang X, Du H, Liu Z, Zhu Q 2009 Relationships between single nucleotide polymorphisms of the H-FABP gene and slaughter and meat quality traits in chicken. Biochem Genet 47:511-520. https://doi.org/10.1007/s10528-009-9249-z

Cited by

  1. Construction of Genetic Linkage Map using Microsatellite and SNP Markers in Korean Native Chicken vol.42, pp.1, 2015, https://doi.org/10.5536/KJPS.2014.42.1.77