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Relationship between Osteoporosis and Cardiovascular Risk Factors according to Sasang Constitution in Rural Wonju Cohort

원주농촌코호트에서 사상체질별 심혈관위험인자와 골다공증의 관계

  • Song, Hak-Soo (Gamchodang Korean Medicine Clinic) ;
  • Choi, Jae-Wan (Yoonjewoo Korean Medicine Clinic) ;
  • Yu, Jun-Sang (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Sangji University) ;
  • Park, Jong-Ku (Dept. of Preventive Medicine, Wonju College of Medicine, Yonsei University)
  • 송학수 (감초당한의원) ;
  • 최재완 (윤제우한의원) ;
  • 유준상 (상지대학교 한의과대학 사상체질의학교실) ;
  • 박종구 (연세대학교 원주의과대학 예방의학교실)
  • Received : 2013.05.06
  • Accepted : 2013.06.21
  • Published : 2013.06.30

Abstract

Objectives The purpose of this study was to investigate the relationship between osteoporosis and cardiovascular risk factors according to Sasang constitution. Methods A total of 1773 participants, over 40 years old, were examined as part of a community-based cohort in Wonju city in Gangwon province of South Korea, from June 2006 to August 2009. We measured bone mineral density by Achilles ultrasonometer, serum levels of lipids, fasting blood sugar, insulin and other cardiovascular risk factors like blood pressure and waist circumference. Constitution was verified by a Sasang constitution specialist using the results of PSSC(Phonetic System for Sasang Constitution), facial photos and a simplified Sasang constitutional questionnaire. Results The prevalence rate was 11.2% in total participants, and 10.6% in Soyangin, 10.4% in Taeeumin and 13.9% in Soeumin. In general characteristics, educational and economic property and exercise were concerned with osteoporosis. Systolic blood pressure, pulse rate and total cholesterol were significantly high in osteoporosis group. Age and menopause were the key risk factors for osteoporosis. There was a significantly high prevalence in Soeumin for osteoporosis in men alone. Low physical activity was a major risk factor for osteoporosis. Waist circumference and hip circumference had significantly high odds ratio and weight had significantly low odds ratio. By Sasang constitution, Soyangin has the negative correlation with free fatty acid, Taeeumin has the negative correlation with waist circumference, pulse rate, systolic blood pressure, total cholesterol and low density lipoprotein and Soeumin has the positive correlation with body fat amount. Conclusions Regimens on osteoporosis should be considered according to Sasang constitution. Cardiovascular diseases should be considered according to Sasang constitution. Soeumin should be cautious of osteoporosis and gain weights and reasonable amount of fat food. Soyangin had better do exercise lower body and eat little food containing triglyceride. Taeeumin had better lose weights and eat little cholesterol food.

Keywords

References

  1. Korean Centers for Disease Control and Prevention. The Third Korean National Health and Nutrition Examination Survey(KNHANES III): summary-2010. Seoul: Korean Centers for Disease Control and Prevention, 2010. (Korean)
  2. Boukhris R, Becker KL. Calcification of the aorta and osteoporosis. JAMA 1972;219:1307-1311. https://doi.org/10.1001/jama.1972.03190360019005
  3. Magnus JH, Broussard DL. Relationship between bone mineral density and myocardial infarction in US adults. Osteoporos Int. 2005;16(12):2053-2062. https://doi.org/10.1007/s00198-005-1999-9
  4. Tanko LB, Bagger YZ, Christiansen C. Low bone mineral density in the hip as a marker of advanced atherosclerosis in elderly women. Calcif Tissue Int 2003;73(1):15-20. https://doi.org/10.1007/s00223-002-2070-x
  5. Farhat GN, Strotmeyer ES, Newman AB, Sutton-Tyrrell K, Bauer DC, Harris T et al. Volumetric and areal bone mineral density measures are associated with cardiovascular disease in older men and women: the health, aging, and body composition study. Calcif Tissue Int. 2006;79(2):102-111. https://doi.org/10.1007/s00223-006-0052-0
  6. Dominguez LJ, Bella GD, Belvedere M, Barbagallo M. Physiology of the aging bone and mechanisms of action of bisphosphonates. Biogerontology. 2011;12:397-408. https://doi.org/10.1007/s10522-011-9344-5
  7. Klift M, Pols HAP, Hak AE, Witteman JCM, Hofman A, Laet CEDH. Bone mineral density and the risk of peripheral arterial disease: the Rotterdam Study. Calcif Tissue Int. 2002;70(6):443-449. https://doi.org/10.1007/s00223-001-2076-9
  8. Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sowa H, Chen Q et al. Plasma lipids and osteoporosis in postmenopausal women. Endocr J. 2002;49(2):211-217. https://doi.org/10.1507/endocrj.49.211
  9. Kammerer CM, Dualan AA, Samollow PB, Périssé AR, Bauer RL, MacCluer JW et al. Bone mineral density, carotid artery intimal medial thickness, and the vitamin D receptor BsmI polymorphism in Mexican American women. Calcif Tissue Int. 2004;75(4):292-298. https://doi.org/10.1007/s00223-004-0215-9
  10. Barengolts EI, Berman M, Kukreja SC, Kouznetsova T, Lin C, Chomka EV. Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women. Calcif Tissue Int. 1998 Mar;62(3):209-213. https://doi.org/10.1007/s002239900419
  11. Hak AE, Pols HA, Hemert AM, Hofman A, Witteman JC. Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population- based longitudinal study. Arterioscler Thromb Vasc Biol. 2000;20:1926-1931. https://doi.org/10.1161/01.ATV.20.8.1926
  12. Vogt MT, San Valentin R, Forrest KY, Nevitt MC, Cauley JA. Bone mineral density and aortic calcification: the Study of Osteoporotic Fractures. J Am Geriatr Soc. 1997;45(2):140-5. https://doi.org/10.1111/j.1532-5415.1997.tb04498.x
  13. Collins TC, Ewing SK, Diem SJ, Taylor BC, Orwoll ES, Cummings SR et al. Peripheral arterial disease is associated with higher rates of hip bone loss and increased fracture risk in older men. Circulation. 2009;119(17):2305-2312. https://doi.org/10.1161/CIRCULATIONAHA.108.820993
  14. Lee JM, Park SS. Dongeuisusebowonsasangchobongwon. Seoul:Jipmoondang. 2003:226-250. (Korean)
  15. Ahn YJ, Lee JE, Cho NH, Shin C, Park C, Oh BS et al. Validation and calibration of semi-quantitative food frequency questionnaire -with participants of the Korean health and genome study-. 2004;9(2):173-182. (Korean)
  16. Kannel WB, McGee D, Gordon T. A general cardiovascular risk profile: the Framingham study. Am J Cardiol. 1976;38(1):46-51. https://doi.org/10.1016/0002-9149(76)90061-8
  17. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study):case-control study. Lancet. 2004;364(9438):937-952. https://doi.org/10.1016/S0140-6736(04)17018-9
  18. Mosca L, Manson JE, Sutherland SE, Langer RD, Manolio T, Barrett-Connor E. Cardiovascular disease in women: a statement for healthcare professionals from the American Heart Association. Circulation. 1997; 96(7):2468-2482. https://doi.org/10.1161/01.CIR.96.7.2468
  19. Ezzati M, Henley SJ, Thun MJ, Lopez AD. Role of smoking in global and regional cardiovascular mortality. Circulation. 2005;112(4):489-497. https://doi.org/10.1161/CIRCULATIONAHA.104.521708
  20. Gotoh M, Mizuno K, Ono Y, Takahashi M. High blood pressure, bone-mineral loss and insulin resistance in women. Hypertens Res. 2005;28(7):565-570. https://doi.org/10.1291/hypres.28.565
  21. Mussolino ME, Gillum RF. Bone mineral density and hypertension prevalence in postmenopausal women; Results from the Third National Health and Nutrition Examination Survey. Ann Epidemiol. 2006;16(5);395-399. https://doi.org/10.1016/j.annepidem.2005.06.051
  22. Kim SR. Relationship between Osteoporosis and Cardiovascular Risk Factors in Premenopausal Women. Master's Degree Thesis of Postgraduate School of Keimyung University. 2010. (Korean)
  23. Buizert PJ, Schoor NM, Lips P, Deeg DJ, Eekhoff EM. Lipid levels: a link between cardiovascular disease and osteoporosis? J Bone Miner Res. 2009;24(6):1103-1109. https://doi.org/10.1359/jbmr.081262
  24. Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sowa H, Chen Q et al. Plasma lipids and osteoporosis in postmenopausal women. Endocr J. 2002;49(2):211-217. https://doi.org/10.1507/endocrj.49.211
  25. Samelson EJ, Cupples LA, Hannan MT, Wilson PW, Williams SA, Vaccarino V et al. Long-term effects of serum cholesterol on bone mineral density in women and men: The Framingham Osteoporosis Study. Bone. 2004;34:557-561. https://doi.org/10.1016/j.bone.2003.11.024
  26. Adami S, Braga V, Zamboni M, Gatti D, Rossini M, Bakri J et al. Relationship between lipids and bone mass in 2 cohorts of healthy women and men. Calcif Tissue Int. 2004;74:136-142. https://doi.org/10.1007/s00223-003-0050-4
  27. Brownbill RA, Ilich JZ. Lipid profile and bone paradox: higher serum lipids are associated with higher bone mineral density in postmenopausal women. J Womens Health (Larchmt). 2006;15(3):261-270. https://doi.org/10.1089/jwh.2006.15.261
  28. Tanko LB, Bagger YZ, Nielsen SB, Christiansen C. Does serum cholesterol contribute to verterbral bone loss in postmenopausal women? Bone. 2003;32:8-14. https://doi.org/10.1016/S8756-3282(02)00918-3
  29. Han BH, Jung HR. Study on relationship between the bone mineral density and cardiovascular risk factor in the postmenopausal women. Journal of Korea Contents Association. 2009;9(10):176-185. (Korean) https://doi.org/10.5392/JKCA.2009.9.10.176
  30. Cui LH, Shin MH, Chung EK, Lee YH, Kweon SS, Park KS et al. Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal rural women in South Korea. Osteoporos Int. 2005;16(12):1975-1981. (Korean) https://doi.org/10.1007/s00198-005-1977-2
  31. Lee JM. Dongeuisusebowon. Seoul:Daesung Publishing Co. 1988:12-13. (Korean)
  32. Jankowska EA, Rogucka E, Medras M. Are general obesity and visceral adiposity in men linked to reduced bone mineral content resulting from normal ageing? A population-based study. Andrologia. 2001;33(6): 384-389. https://doi.org/10.1046/j.1439-0272.2001.00469.x

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