Journal of Korean society of Dental Hygiene (한국치위생학회지)

Korean Society of Dental Hygiene (한국치위생학회)
권호 표지
DOI QR코드

DOI QR Code

Evaluation of saliva and cariogenic activity in patients with hematologic malignancy

혈액종양환자의 타액과 치아우식활성도 평가

  • Kim, Hyeoung-Joon (Department of Hematology/Oncology, Research Institute of Medical Sciences Chonnam National University Medical School) ;
  • Jeong, Kyung-Yi (Chonnam National University Hwasun Hospital) ;
  • Park, Ji-Il (Department of Dental Hygiene, Gwangju Health University)
  • 김형준 (전남대학교 의과대학 혈액종양내과) ;
  • 정경이 (화순전남대학교병원 치과) ;
  • 박지일 (광주보건대학교 치위생과)
  • Received : 2013.05.22
  • Accepted : 2013.06.18
  • Published : 2013.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : This study was performed to evaluate the salivary secretion, salivary pH and cariogenic activity using unstimulated whole saliva in patients with hematologic malignancy. Methods : Nineteen patients (9 male, 10 female) who had hematologic malignancy and were treated with chemotherapy or bone marrow transplantation, and nineteen normal volunteers (7 male, 12 female) as control group were included. The mean age of patients group and control group was 45.1 and 46.7 years, respectively. Patients group was examined salivary secretion, salivary pH, and cariogenic activity using unstimulated whole saliva and was compared with control group. Results : In comparison with control group, salivary secretion, salivary pH and salivary buffer capacity were significantly lower in patients with hematologic malignancy (p<0.01). Both cariogenic activity(p<0.01) and the number of Lactobacilli(p<0.05) are higher in patients group than control group. Conclusions : These results suggest that the unstimulated whole salivary secretion, pH and buffer capacity were lower in patients with hematologic malignancy than control group. Cariogenic activity is higher in patients with hematologic malignancy than control group. Such salivary factor and cariogenic activity can increase the possibility of induction of dental caries.

Keywords

References

  1. Burke VP, Startzell JM. The leukemias. Oral Maxillofac Surg Clin North Am 2008; 20: 597-608. https://doi.org/10.1016/j.coms.2008.06.011
  2. Wiener CM, Fauci AS, Braunwald E, Kasper DL, Hauser S. Harrison's principles of internal medicine. 17th ed. The United States of America: The McGraw-Hill; 2008: 677.
  3. Chang AE, Ganz PA, Hayes DF, Kinsella T, Pass H.I, Schiller J.H et al. Oncology: an evidence-based approach. New York: Springer; 2006: 1340-1.
  4. Carl W. Oral complications of local and systemic cancer treatment. Curr Opin Oncol 1995; 7: 320-4. https://doi.org/10.1097/00001622-199507000-00005
  5. Kim JB, Nam KY, Chung WG, Noh HJ, Jang SO, Yoo JH et al. A clinical study on the care of oral complications in the admission patients with major malignant tumors. J Korean Assoc Maxillofac Plast Reconstr Surg 2004; 26: 53-60.
  6. Silverman S Jr. Oral cancer: complications of therapy. Oral Surg Oral Med Pathol Oral Radiol Endod 1999; 88: 122-6. https://doi.org/10.1016/S1079-2104(99)70103-4
  7. Jeong KI, Lim HS. Analysis on saliva of head and neck cancer patients. J Korean Acad Oral Health 2012; 36: 303-8. https://doi.org/10.11149/jkaoh.2012.36.4.303
  8. Kang SM, Jung HI, Jeong SH, Kwon HK, Kim BI. Development of a new color scale for a caries activity test. J Korean Acad Oral Health 2010; 34: 9-17.
  9. Drucker DB. The role of sugar in the etiology of dental caries. The microbiological evidence. J Dent 1983; 11: 205-7. https://doi.org/10.1016/0300-5712(83)90185-9
  10. Newbrun E. Cariology. 3rd ed. Chicago: Quintessence Publish; 1989: 289-99.
  11. Kwon HK, Kim DK, Kim BI, Kim YN, Ma DS, Park DY et al. Primary preventive dentistry. 6th ed. Seoul: DaehanNarae; 2006: 264-72.
  12. Parvinen T, Larms M. The relation of stimulated salivary flow rate and pH to Lactobacillus and yeast concentrations in saliva. J Dent Res 1981; 60: 1929-35. https://doi.org/10.1177/00220345810600120201
  13. Beck H, Wainwright WW. Human saliva XI; the effect of activation on salivary flow. J Dent Res 1939; 18: 447-56. https://doi.org/10.1177/00220345390180050601
  14. Miller CS, Foley JD, Bailey AL, Humphries RL, Christodoulides N, Floriano PN et al. Current developments in salivary diagnostics. Biomark Med 2010; 4: 171-89. https://doi.org/10.2217/bmm.09.68
  15. Kim MY, Lee HJ. A study on the correlation between caries activity test result and dental caries experience. J Dent Hyg Sci 2008; 14: 131-7.
  16. Kim JS, Lee SI, Cheon JS, Kim HC, Park KP, Kim KN et al. Physiology for dentistry. 2nd ed. Seoul: DaehanNarae; 2009:243-69.
  17. Jeong SJ, Apostolska S, Jankulovska M, Angelova D, Nares S, Yoon MS et al. Dental caries risk can be predicted by simply measuring the pH and buffering capacity of saliva. J Dent Hyg Sci 2006; 6: 159-62.
  18. Närhi TO, Kurki N, Ainamo A. Sailva, salivary microorganism, and oral health in the home-dwelling old elderly-a five- year longitudinal study. J Dent Res 1999; 78: 1640-6. https://doi.org/10.1177/00220345990780100901
  19. Heintze U, Frostell G, Lindgärde F, Trell E. Secretion rate and buffer effect of resting and stimulated whole saliva in relation to general health. Swed Dent J 1986; 10: 213-9.
  20. Epstein JB, Tsang AH, Warkentin D, Ship JA. The role of salivary function in modulating chemotherapy-induced oropharyngeal mucositis: a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 94: 39-44. https://doi.org/10.1067/moe.2002.126018
  21. Hicks J, Garcia-Godoy F, Flaitz C. Biological factors in dental caries: role of saliva and dental plaque in the dynamic process of demineralization and remineralization (part 1). J Clin Pediatr Dent 2003; 28: 47-52.
  22. Lenander-Lumikari M, Loimaranta V. Saliva and dental caries. Adv Dent Res 2000; 14: 40-7. https://doi.org/10.1177/08959374000140010601
  23. Dowd FJ. Saliva and dental caries. Dent Clin North Am 1999; 43: 579-97.
  24. Cho MJ, Kim JH, Kim EM, Lee HN. The correlation between dental caries experience and improved dental caries activity tests for the students of dental hygiene. J Korean Acad Dent Hyg Educ 2003; 3: 197-208.
  25. Russell JI, MacFarlane TW, Aitchison TC, Stephen KW, Burchell CK. Caries prevalence and microbiological and salivary caries activity tests in Scottish adolescents. Community Dent Oral Epidemiol 1990; 18(3): 120-5. https://doi.org/10.1111/j.1600-0528.1990.tb00035.x
  26. Tong HC, Gao XJ, Dong XZ. Non-mutans streptococci in patients receiving radiotherapy in the head and neck area. Caries Res 2003; 37: 261-6. https://doi.org/10.1159/000070868
  27. Wahlin YB, Holm AK. Changes in the oral microflora in patients with acute leukemia and related disorders during the period of induction therapy. Oral Surg Oral Med Oral Pathol 1988; 65:411-7. https://doi.org/10.1016/0030-4220(88)90354-4
  28. Hojo S, Komatsu M, Okuda R, Takahashi N, Yamada T. Acid profiles and pH of carious dentin in active and arrested lesions. J Dent Res 1994; 73: 1853-7.
  29. Cho MJ. A study on the outcome of IDC(Incremental Dental Care). J Korean Acad Dent Hyg Educ 2009; 9: 153-68.

Cited by

  1. A Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Acidogenic Potential of Dental Biofilms through a Tablet Containing Weissella cibaria CMU vol.18, pp.9, 2013, https://doi.org/10.3390/ijerph18094674