Korean journal of food and cookery science (한국식품조리과학회지)

Korean Society of Food and Cookery Science (한국식품조리과학회)
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Comparison of Antioxidant and Anti-proliferative Activities of Perilla (Perilla frutescens Britton) and Sesame (Seasamum indicum L.) leaf extracts

들깻잎과 참깻잎 추출물의 항산화 활성 및 대장암세포 증식 억제 활성 비교분석

  • Kwak, Youngeun (Department of Food and Nutrition, Chungbuk National University) ;
  • Ki, Seoha (Department of Food and Nutrition, Chungbuk National University) ;
  • Noh, Eun Kyoung (Department of Food and Nutrition, Chungbuk National University) ;
  • Shin, Ha Neul (Department of Food and Nutrition, Chungbuk National University) ;
  • Han, Young-Ju (Department of Food and Nutrition, Chungbuk National University) ;
  • Lee, Yuna (Department of Food and Nutrition, Chungbuk National University) ;
  • Ju, Jihyeung (Department of Food and Nutrition, Chungbuk National University)
  • 곽영은 (충북대학교 식품영양학과) ;
  • 기서하 (충북대학교 식품영양학과) ;
  • 노은경 (충북대학교 식품영양학과) ;
  • 신하늘 (충북대학교 식품영양학과) ;
  • 한영주 (충북대학교 식품영양학과) ;
  • 이유나 (충북대학교 식품영양학과) ;
  • 주지형 (충북대학교 식품영양학과)
  • Received : 2012.11.13
  • Accepted : 2013.03.05
  • Published : 2013.06.29
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Abstract

This study was to compare the antioxidant and anti-proliferative activities of perilla (Perilla frutescens Britton) and sesame (Seasamum indicum L.) leaf extracts. The total polyphenol levels of sesame leaf ($634.7{\pm}1.2$ mg gallic acid equivalent/100 g dried leaf) were higher than those of perilla leaf ($408.7{\pm}4.6$ mg gallic acid equivalent/100 g dried leaf; p<0.001). The total flavonoid levels of sesame leaf ($166.7{\pm}17.3$ mg quercetin equivalent/100 g dried leaf) were also higher than those of perilla leaf ($108.2{\pm}3.7$ mg quercetin equivalent/100 g dried leaf; p<0.05). ABTS radical- and DPPH radical-scavenging activities of sesame leaf extracts (78.9% and 18.2%, respectively) were higher than those of perilla leaf extracts (46.0% and 9.0%, respectively; p<0.01). Both perilla and sesame leaf extracts significantly inhibited the growth of HCT116 human colon cancer cells. However, the inhibitory activities of sesame leaf extracts were more pronounced than those of perilla leaf extracts (p<0.001). These results indicate that sesame leaf extracts have higher antioxidant and anti-proliferative activities than perilla leaf extracts. More studies are needed in order to enhance the sensory value of sesame leaf and to develop sesame leaf as health/functional food ingredients.

들깻잎은 독특한 향미가 있어 다양한 형태로 빈번히 식용되고 있는 반면 참깻잎은 특별한 향미가 없어 그 기호성이 낮아 거의 식용되지 않는 폐자원이다. 들깻잎의 경우 다양한 기능성이 보고된 바 있으나, 참깻잎의 경우에는 통상적으로 식품으로 이용되는 자원이 아니기 때문에 그 기능성에 대한 연구가 전무한 실정이다. 이에 본 연구에서는 들깻잎과 참깻잎의 항산화 성분함량 및 활성을 비교하여, 참깻잎의 항산화 및 항암 기능성을 조명해 보고자 하였다. 식물성 식품에 널리 존재하는 대표적인 항산화 성분인 폴리페놀과 플라보노이드의 함량을 들깻잎과 참깻잎 추출물에서 측정한 결과, 참깻잎의 총 폴리페놀 및 총 플라보노이드 함량은 들깻잎의 함량의 약 1.5-1.6배 수준이었으며(p<0.05), 참깻잎의 ABTS radical 및 DPPH radical 소거활성 또한 들깻잎 활성의 약 1.7-2배 수준이었다(p<0.01). 또한 참깻잎은 들깻잎보다 대장암세포의 성장을 억제하는 활성이 높은 것으로 나타났다(p<0.001). 이러한 연구 결과는 향후 참깻잎의 항암성을 포함한 다양한 기능성 및 관련 작용기전을 규명하고, 나아가 참깻잎을 이용한 기능성 식품을 개발하기 위한 기초자료로 이용될 수 있을 것으로 생각된다. 또한 참깻잎의 기호성을 증진시키기 위한 조리과학적 연구 등과 같은 참깻잎의 식품학적 가치를 재조명하는 다양한 연구들이 앞으로 종합적으로 수행된다면, 이제까지 폐자원으로 여겨졌던 참깻잎의 새로운 자원화를 통한 경제적인 효과도 기대할 수 있을 것으로 생각된다.

Keywords

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