Journal of Acupuncture Research

  • 제30권3호
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  • Pages.15-25
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  • 2013
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  • 2586-288X(pISSN)
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  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
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비파엽약침이 고지방식이 유발 비만 생쥐의 국소부위지방에 미치는 영향

The Efficacy of Eriobotryae Folium Pharmacopuncture on Local Fat of High Fat Diet Induced Obesity Mice

  • 노성수 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김재수 (대구한의대학교 한의과대학 침구의학교실) ;
  • 임성철 (대구한의대학교 한의과대학 침구의학교실)
  • Roh, Sung Soo (Department of Herbology, College of Oriental Medicine, Daegu Haany University) ;
  • Kim, Jae Soo (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Yim, Sung Cheol (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Daegu Haany University)
  • 투고 : 2013.04.15
  • 심사 : 2013.05.21
  • 발행 : 2013.06.20
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초록

Objectives : This study was designed to investigate the anti-obesity effects in local area adipose tissue using by pharmacopuncture of Eriobotryae Folium on mice fed high fat diet. Methods : Male ICR mouse were divided into three groups. Normal diet group (N), High-fat diet(HFD) group, HFD+E(pharmacopuncture of the Eriobotryae Folium) group for 8 weeks. HFD+E group was injected in the concentration of 50 mg/kg once a day for 4 weeks and every other day during the next 4 weeks. We measured body weight, food intake, absolute weight and relative weight in the liver and adipose tissue. Also, we analyzed hematological levels and histopathological changes on adipose tissue. Results : 1. We observed no difference in food intake among three groups. 2. HFD+E group significantly decreased body weight gain and absolute weight and relative weight in the liver and adipose tissue compared with HFD group. 3. Blood AST and ALT were no differences among the experiment groups. However, HFD group was significantly increased higher TG, TC, HDL and LDL than in N group and HDL/LDL ratio was remarkably decreased. On the other hand, HFD+E group was significantly decreased in obesity markers and HDL/LDL ratio was remarkably increased. 4. Levels of adiponectin in serum of HFD+E group was remarkably increased compared with those of HFD group. 5. HFD group was significantly decreased compared with N group in adipocyte number. Compared with the HFD group, HFD+E group was displayed a significant increase by adipocyte number. Conclusions : We suggest that pharmacopuncture of the Leaves of Eriobotrya japonica can play the anti-obesity effects in local area adipose tissue.

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