Journal of Acupuncture Research

  • 제30권3호
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  • Pages.125-134
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  • 2013
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  • 2586-288X(pISSN)
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  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
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현종(懸鍾)($GB_{39}$).양릉천(陽陵泉)($GB_{34}$)의 전침(電鍼) 및 레이저침이 백서(白鼠)의 신경병리성(神經病理性) 동통(疼痛)에 미치는 영향

Effects of Electro and Laser Acupuncture Treatment with $GB_{39}$ and $GB_{34}$ on Neuropathic Pain in Rats Induced by Tibial and Sural Nerve Ligation

  • 김용세 (동신대학교 한의과대학 침구의학교실) ;
  • 이주희 (동신대학교 한의과대학 침구의학교실) ;
  • 이상현 (동신대학교 한의과대학 침구의학교실) ;
  • 나창수 (동신대학교 한의과대학 경혈학교실) ;
  • 조명래 (동신대학교 한의과대학 침구의학교실)
  • Kim, Yong Se (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dong-shin University) ;
  • Lee, Ju Hee (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dong-shin University) ;
  • Lee, Sang Hyun (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dong-shin University) ;
  • Na, Chang Su (Department of Meridian & Acupoint, College of Korean Medicine, Dong-shin University) ;
  • Cho, Myoung Rae (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Dong-shin University)
  • 투고 : 2013.05.20
  • 심사 : 2013.06.10
  • 발행 : 2013.06.20
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초록

Objectives : We studied the effects of electro and laser acupuncture treatment with $GB_{39}$ and $GB_{34}$ on neuropathic pain in rats induced by tibial and sural nerve ligation. Methods : To produce the model of neuropathic pain, the tibial and sural nerves of rats were ligated by a 6-0 silk thread. Three days after the neuropathic surgery, only electro acupuncture(EA), electro acupuncture and 830 nm laser acupuncture(EA-LA-1), and electro acupuncture and 904 nm laser acupuncture(EA-LA-2) were treated with $GB_{39}$ and $GB_{34}$ twice a week for 8 weeks. We observed the withdrawal response of neuropathic rats' legs by von Frey filament and acetone stimulation. We also observed c-fos and nocieptin on the central gray area in the midbrain of neuropathic rats. Results : As we observed the effect of mechanical allodynia, the EA and EA-LA-1 groups in 5 and 6 weeks and the EA-LA-2 group in 6 weeks increased significantly compared with the control group. As for the effect of c-fos activity in the central gray region, the EA, EA-LA-1, and EA-LA-2 groups decreased significantly compared with the control group. The EA-LA-2 group increased significantly compared with the control group as regards the effect of nociceptin activity in the central gray region. Conclusions : We noticed the synergic effect of electro and laser acupuncture treatment because the EA-LA-1 and EA-LA-2 groups had more controllable effect compared with the control group. This study can be used in clinical therapy for neuropathic pain.

키워드

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