The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Hepatoprotective Effects of Hovenia dulcis Extract on Acute and Chronic Liver Injuries induced by Alcohol and Carbon Tetrachloride

알코올 및 사염화탄소에 의해 유발된 급만성 간손상에 대한 지구자 열수추출물의 보호효과

  • Kim, Young-Sik (Korea Institute of Science and Technology for Eastern Medicine, NeuMed Co., Ltd.) ;
  • Park, Juyeon (Korea Institute of Science and Technology for Eastern Medicine, NeuMed Co., Ltd.) ;
  • Kwon, Yongbeom (Korea Institute of Science and Technology for Eastern Medicine, NeuMed Co., Ltd.) ;
  • Lim, Dong Wook (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Song, MiKyung (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Choi, Ho-Young (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Hocheol (Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University)
  • 김영식 (뉴메드 한의과학기술연구소) ;
  • 박주연 (뉴메드 한의과학기술연구소) ;
  • 권용범 (뉴메드 한의과학기술연구소) ;
  • 임동욱 (경희대학교 한의과대학 본초학교실) ;
  • 송미경 (경희대학교 한의과대학 본초학교실) ;
  • 최호영 (경희대학교 한의과대학 본초학교실) ;
  • 김호철 (경희대학교 한의과대학 본초학교실)
  • Received : 2013.06.19
  • Accepted : 2013.07.19
  • Published : 2013.07.30
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Abstract

Objectives : The purpose of this study was to evaluate the hepatoprotective effect of Hovenia dulcis extract on acute and chronic liver injuries induced by alcohol and $CCl_4$ in mice and rats. Methods : In acute alcohol-induced liver injury, mice were administered Hovenia dulcis extracts (60 and 200 mg/kg) orally before and after alcohol administration. In chronic alcohol-induced liver injury, mice were administered alcohol containing liquid diet for 4 weeks. The mice were administered H. dulcis extracts (60 and 200 mg/kg) mixed with the liquid diet. In acute $CCl_4$-induced liver injury, rats received a single dose of $CCl_4$ (2 mL/kg in olive oil, intraperitoneally). Rats were administered H. dulcis extracts (30, 100 and 300 mg/kg) before and after $CCl_4$ administrations. After the ends of the administrations, the serum levels of AST and ALT were measured using chemical analyzer, and ${\gamma}$-GTP levels were measured using spectrophotometer. Results : In acute alcohol-induced liver injury, H. dulcis extracts treated group showed significant reduction in ALT levels compared to those of control group. In chronic alcohol-induced liver injury, it inhibited weight-loss compared to normal group and showed significant reduction in AST, ALT and ${\gamma}$-GTP levels compared to control group. In acute $CCl_4$-induced liver injury, it also showed significant reduction in AST, ALT levels compared to control group. Conclusions : The results show that H. dulcis extract has hepatoprotective effect in acute and chronic alcohol-induced liver injury and acute $CCl_4$-induced liver injury. These findings suggest that H. dulcis could be a potent hepatoprotective agent.

Keywords

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