DOI QR코드

DOI QR Code

Effects of Dioscoreae Rhizoma (SanYak) on Peripheral Neuropathy and its Safety

  • Kim, Min-Jung (Department of Acupuncture & Moxibustion, Oriental Hospital of Daejeon University) ;
  • Sung, Hyunkyung (Department of Oriental Pediatrics, Oriental Hospital of Daejeon University) ;
  • Hong, Kwon-Eui (Department of Acupuncture & Moxibustion, Oriental Hospital of Daejeon University)
  • 투고 : 2013.04.23
  • 심사 : 2013.05.31
  • 발행 : 2013.09.30

초록

Objectives: This study aimed to evaluate the evidence available in the literature for the safety and efficacy of Dioscoreae Rhizoma (DR) for the treatment of peripheral neuropathy. Methods: Literature searches were performed in MEDLINE and three Korean medical databases up to April 2013. All studies evaluating the effects on peripheral neuropathy or the safety of DR monopreparations were considered. Results: Three studies - DR extract per os (po) on diabetic neuropathy in mice, DR extract injection on the peripheral sciatic nerve after crush injury in rats and DR extract injection to patients with peripheral facial paralysis proved that DR treatments were effective for the treatment of nerve injuries. Conclusions: In conclusion, we found the DR has a strong positive potential for the treatment of peripheral neuropathy, but studies addressing direct factors related to the nerve still remain insufficient.

키워드

참고문헌

  1. Kang TH, Choi SZ, Lee TH, Son MW, SY Kim. [Characteristics of antidiabetic effect of Dioscorea rhizome (1) -Hypoglycemic Effect-.] Korean J Food & Nutr. 2008;21(4):425-9. Korean.
  2. Kang TH, Choi SZ, Lee TH, Son MW, Park JH, Kim SY. [Characteristics of Antidiabetic Effect of Dioscorea rhizome (2) -Prevention of Diabetic Neuropathy by NGF Induction-.] Korean J Food & Nutr. 2008;21(4):430-5. Korean.
  3. Liu CZ, Zhou HY, Yan Q. Fingerprint analysis of Dioscorea nipponica by high-performance liquid chromatography with evaporative light scattering detection. Analytica Chimica Acta. 2007;582(1):61-8. https://doi.org/10.1016/j.aca.2006.08.057
  4. Akahori A. Studies on the steroidal components of domestic plants-XLIV. : Steroidal sapogenins contained in Japanese Dioscorea sp. Phytochemistry. 1965;4(1):97-106. https://doi.org/10.1016/S0031-9422(00)86151-8
  5. Jayakody L, Hoover R, Liu Q, Donner E. Studies on tuber starches. II. Molecular structure, composition and physicochemical properties of yam (Dioscorea sp.) starches grown in Sri Lanka. Carbohydr Polym. 2007;69(1):148-63. https://doi.org/10.1016/j.carbpol.2006.09.024
  6. Fu YC, Ferng LHA, Huang PY. Quantitative analysis of allantoin and allantoic acid in yam tuber, mucilage, skin and bulbil of the Dioscorea species. Food Chemistry. 2006;94(4):54-9.
  7. Park CL, Lee JS. Mini Review: Natural ingredients for diabetes which are approved by Korean FDA. Biomedical Research. 2013;24(1):164-9.
  8. Martyn CN, Hughes RAC. Epidemiology of peripheral neuropathy. J Neurol Neurosurg Psychiatry. 1997;62(4):310-8. https://doi.org/10.1136/jnnp.62.4.310
  9. US National Institute of Neurological Disorders and Stroke (NINDS). Peripheral neuropathy fact sheet NIH Publication No. 04-4853 [Internet]. Bethesda (MD): National Institutes of Health; c2012. [cited 2012 Aug 10]. Available from: http://www.ninds.nih.gov/disorders/peripheralneuropathy/detail_peripheralneuropathy.htm.
  10. Ko MK, Hong KE. Evaluation of the safety of Sanyak (Dioscoreae Rhizoma) pharmacopuncture according to the extraction method: a double-blind randomized controlled trial. J Acupunct Meridian Stud. 2013;6(1):41-51. https://doi.org/10.1016/j.jams.2012.12.003
  11. Hur GY, Park HJ, Kim HA, Ye YM, Park HS. Identification of Dioscorea batatas (Sanyak) allergen as an inhalant and oral allergen. J Korean Med Sci. 2008;23(1):72-6.
  12. Aloe L, Bracci-Laudiero L, Bonini S, Manni L. The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases. Allergy. 1997;52(9):883-94. https://doi.org/10.1111/j.1398-9995.1997.tb01247.x
  13. Lee JM, Namgung U, Hong KE. Growth-promoting activity of Sanyak (Dioscoreae rhizoma) extract on injured sciatic nerve in rats. J Acupunct Meridian Stud. 2009;2(3):228-35. https://doi.org/10.1016/S2005-2901(09)60059-5
  14. Skene JH, Willard M. Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systems. J Cell Biol. 1981;89(1):96-103. https://doi.org/10.1083/jcb.89.1.96
  15. Gispen WH, Boonstra J, De Graan PNE, Jennekens FG, Oestreicher AB, Schotman P, et al. B-50/GAP-43 in neuronal development and repair. Restorat Neurol Neurosci. 1990;1(3):237-44.
  16. Hunt T. Cyclins and their partners: from a simple idea to complicated reality. Semin Cell Biol. 1991;2(4):213-22.
  17. Sung IS, Hong KE, Kim MJ, Song I. Clinical research of the efficacy and the safety of Dioscoreae Rhizoma (Sanyak) pharmacopuncture therapy for peripheral facial paralysis patients. Pharmacopuncture. 2012;15(4):15-24. https://doi.org/10.3831/KPI.2012.15.010
  18. Zhong X, Nishino E, Okagami N. Temperature dependence of seedling establishment of a perennial, Dioscorea tokoro. J Plant Res. 2002;115(1117):55-7. https://doi.org/10.1007/s102650200008
  19. The Compilation Committee of Oriental Medicine University. Herbal medicine. Seoul:Younlimsa;2004. p. 583-4.
  20. Lee SC, Tsai CC, Chen JC, Lin CC, Hu ML, Lu S. The evaluation of reno- and hepatoprotective effects of huai-shan-yao (Rhizome Dioscoreae). Am J Chin Med. 2002;30(4):609-16. https://doi.org/10.1142/S0192415X02000624
  21. Tewtrakul S, Itharat A. Nitric oxide inhibitory substances from the rhizomes of Dioscorea membranacea. J Ethnopharmacol. 2007;109(3):412-6. https://doi.org/10.1016/j.jep.2006.08.009