DOI QR코드

DOI QR Code

The Anxiolytic, Anti-Depressive Effects Using Bambusae Caulis in Taeniam Extract in Rat Chronic Immobilization Stress Model

구속스트레스로 불안과 우울증상을 일으킨 백서에서 죽여의 개선 효과

  • Lyu, Yun-Sun (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Park, Jong-Min (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Ko, In-Sung (Department of Oriental Neuropsychiatry, Dongseo Oriental Medical Center) ;
  • Kang, Hyoung-Won (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Won-Kwang University) ;
  • Lyu, Yeoung-Su (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Won-Kwang University)
  • 유윤선 (원광대학교 한의과대학 신경정신과학교실) ;
  • 박종민 (원광대학교 한의과대학 신경정신과학교실) ;
  • 고인성 (동서한방병원 한방신경정신과) ;
  • 강형원 (원광대학교 한의과대학 신경정신과학교실) ;
  • 유영수 (원광대학교 한의과대학 신경정신과학교실)
  • Received : 2013.08.01
  • Accepted : 2013.08.22
  • Published : 2013.09.30

Abstract

Objectives : The Bambusae Caulis in Taeniam has been used in traditional oriental medicine to treat a variety of mental disorders including anxiety and depression. The purpose of present study is to observe the changes which take place in the body in stressful situations and to compare the anti-depressive, anxiolytic and anti-stress effect of Bambusae Caulis in Taeniam in different doses. Methods : This study was performed to evaluate the effects of Bambusae Caulis in Taeniam in the immobilization stress model in rats. Twenty-five rats were divided into 5 groups of 5: control, stress, low dose administration (75 mg/kg), medium dose administration (150 mg/kg) and high dose administration (225 mg/kg). The four groups other than the control group were placed in an immobilization stress test, and distilled water (control) or Bambusae Caulis in Taeniam extract was administration orally for 2 weeks. After treatment, the despair and anxiety behavior of rats were measured by open field test, forced swimming test, weight gain, contents of 5-HT in raphe nucleus and adrenal gland weight. Results & Conclusions : As a result of evaluation by measuring five aspects, FST, OFT, weight gain, 5-HT contents and adrenal gland weight, Bambusae Caulis in Taeniam has significant antidepressant, anxiolytic, anti-stress effects.

Keywords

References

  1. The Textbook Compilation Committee of Neuropsychiatry of Oriental Medical Schools in Nation. Revised Edition. The Neuropsychiatry of Oriental medicine. Seoul: Jipmoondang; 2011;130:101-4, 197-203, 235-42, 264-73.
  2. Lyu YS. A Psychiatric Study on the Stasis Symptoms Complex. Wonkwang Oriental Medicine. 1995;5(1):125-40.
  3. Cannon WB. The Wisdom of the Body. New York: Norton & Company Ins; 1963;19-40.
  4. Seleys H. The Stress of Life. Toronto: Congmans Green and Co; 1958;1-50.
  5. Ahn SW. Understanding the Conception of Stress Regard in the Oriental Medicine. Korean Journal of Oriental Medicine. 1997;3(1):119-51.
  6. Kim JW. The View on Stress in Oriental Medicine, Journal of Oriental Neuropsychiatry. 1993;4(1): 19-26.
  7. Min SG. Modern Psychiatry, 5th Edition. Seoul: Ilchokak; 2006;52-67, 274-97, 323-58, 743-56.
  8. Hyman SE. The Genetics of Mental Illness: Implications for Practice. Bulletin of the World Health Organization. 2000;78(4):455-63.
  9. Voorhees JL, Tarr AJ, Wohleb ES, et al. Prolonged Restraint Stress Increases IL-6, Reduces IL-10, and Causes Persistent Depressive-Like Behavior That Is Reversed by Recombinant IL-10. PLoS ONE. 2013;8(3):e58488. https://doi.org/10.1371/journal.pone.0058488
  10. Lee TH, Min NG. Effects of Paeoniae Radix Rubra on CRF, c-Fos and TH in FTS. Korean Journal for Herbology. 2010;25(4):61-7.
  11. Kwon YW, Lee TH. Antidepressant Effects of Citri Reticulatae Viride Pericarpium in the Forced Swimming Test. Korean Journal for Herbology. 2008;23(4):59-70.
  12. Sim EY, Lee TH. Effects of Mixture of Lycii Radicis Cortex and Moutan Cortex on Corticotropin-Releasing Factor, c-Fos, and Tyrosine Hydroxylase in Forced Swimming Test. Korean Journal for Herbology. 2011;26(2):59-66.
  13. Lee DG, Kwak DG, Park SD. Antidepressant Effect of Licium Chinense Mill. and Its Influence on Serotonin and Its Metabolite of Depression Model Rats. The Korean Journal Of Oriental Medical Prescription. 2004;11(2):185-96.
  14. Kim IJ, Lee DW. Experimental Study on the Antidepressant Effect of Ginseng Radix Alba and Cyperi Rhizoma. Journal of Oriental Neuropsychiatry. 2004;15(1):101-19.
  15. Kang JH, Lee DW, Hah JH. Modulation of Ligand Binding to the GABAA-Benzodiazepine Receptor Complex by C. Officinale. Journal of the Korean Society of Biological Therapies in Psychiatry. 1997;3(2):168-74.
  16. Lee BJ, Kim JW, Jee EY, Yun SY, Lee SM, Lyu JH. Original Articles: Anxiolytic and Antidepressive Effect of Non-saponin Fraction of Korean Red Ginseng. Korean Journal for Herbology. 2009;24(4):143-8.
  17. Yun HY. Bupleurum Falcatum Prevents Depression Andanxiety-Like Behaviors in the Rats Exposed to Repeated Restraint Stress. Graduate School of Oriental Medicine KyungHee University; 2012;1-41.
  18. Kim YH, Choi HC, Son ED, Lee KY, Kim WJ, Park HB. Anxiolytic Action of Gastrodia Elata Blume. Journal of the Korean Society of Biological Therapies in Psychiatry. 1996;2(2):108-14.
  19. Choi YH, Jung JW. Anxiolytic-Like Effects of Scrophularia Buergeriana Miquel Using the Elevated Plus-Maze in Mice: Involvement of GABAergic Nervous System. Korean Journal of Oriental Physiology and Pathology. 2010;24(3):476-83.
  20. Shin MK. Clinical Traditional Herbalogy. Seoul: Younglimsa; 1996;759.
  21. Park SJ, Kim JW, Hwang EW, Kim HT, Jee SE, Kim WR. The Effects of Bambusae Caulis and St. John's Wort in the Chronic Mild Stress Model of Depression in Rats. Journal of Oriental Neuropsychiatry. 2004;15(2):53-70.
  22. Ro SK. The Effect of Binding Stressed White Rats by Chijashitang and Chijashitang+Bambusea Caulis. Dept of Neuropsychiatry Graduate School Kyungsan University; 1995;1-36.
  23. Hong ND, Kim NJ, Kong YW, Kwon CH, Jang SO. Studies on the Pharmacological Activity and Constituents of Bambusae Caulis in Taeniam Hyllostachys Sp.). Korean Journal of Pharmacognosy. 1988;19(1):79.
  24. Oh JG. Chemical Properties of Bamboo Skin and Its Antimicrombial Activities. Dept of Food Science and Technology Graduate School Chonnam National University; 1995;1-49.
  25. Kang TW. Effect of Bambusae Caulis, Bamboo Lea and Phyllostachys Nigra Var Henonis on Hyperlipidemia. Dept of Oriental Internal Medicine Graduate School Dajeon University; 1995; 1-41.
  26. Cox T. Stress. Hong Kong: Palgrave Macmillan Limited; 1978.
  27. Kolb LD. Modern Clinical Psychiatry, 10th Edition. Philadelphia: WB Saunders Company; 1982.
  28. Valliant GE. Adaptive Mental Mechanisms. American Psychologist. 2000;55(1):89-98. https://doi.org/10.1037/0003-066X.55.1.89
  29. Cohen S, Janicki-Deverts D, Miller GE. Psychological Stress and Disease. JAMA. 2007;298(14): 1685-7. https://doi.org/10.1001/jama.298.14.1685
  30. Dell'Osso B, Buoli M, Baldwin DS, Altamura AC. Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) in Anxiety Disorders: A Comprehensive Review of Their Clinical Efficacy. Hum Psychopharmacol. 2010;25(1):17-29. https://doi.org/10.1002/hup.1074
  31. Lazarus RS, Folkman S. Stress, Appraisal, and Coping. New York: Springer; 1984.
  32. Folkman S, Moskowitz JT. Stress, Positive Emotion, and Coping. Current Directions in Psychological Science. 2000;9(4):115-8. https://doi.org/10.1111/1467-8721.00073
  33. Kang HW, Jang HH, Kang IS, Mun HC, Hwang YJ, Lyu YS. A Study on the Riental-Medical Understanding of Depression. Journal of Oriental Neuropsychiatry. 2001;12(2):1-15.
  34. Bear MF, Connors BW, Paradiso MA. Neuroscience: Exploring the Brain, 3rd Edition. Seoul: Biomedibook; 2009.
  35. Lee KW, Kang SK, Chun YH, Hong JP. The Effect of Repeated Restraint Stress on Clusterin Change of the Rat Salivary Glands. The Journal of Korean Academy of Oral Medicine. 2012;37(2):81-91.
  36. Porsolt RD, Le Pichon M, Jalfre M. Depression: a New Animal Model Sensitive to Antidepressant Treatments. Nature. 1977;266:730-2. https://doi.org/10.1038/266730a0
  37. Cryan JF, McGrath C, Leonard BE, Norman TR. Combining Pindolol and Paroxetine in an Animal Model of Chronic Antidepressant Action. Can Early Onset of Action Be Detected? Eur J Pharmacol. 1998;352:23-8. https://doi.org/10.1016/S0014-2999(98)00402-6
  38. Porsolt RD, Anton G, Blavet N, Jalfre M. Behavioral Despair in Rats: A New Model Sensitive to Antidepressant Treatments. Eur J Pharmacol. 1978;15:379-91.
  39. Shin KH. Animal Models of Depression and Screening of Antidepressants. Korean J Psychopharmacol. 2000;11(4):291-303.
  40. Prut L, Belzung C. The Open Field as a Paradigm to Measure the Effects of Drugs on Anxiety-Like Behaviors: A Review. European Journal of Pharmacology. 2003;463:3-33. https://doi.org/10.1016/S0014-2999(03)01272-X
  41. Shin DH, Shin JY, Kim SH, Kim JH, Jung HJ, Kim JC. Single Oral Dose Toxicity Study of Balbusae Caulis in Taeniam in Rats. J Toxicol Pub Health. 2004;20(4):325-8.
  42. Cryan JF, Holmes A. The Ascent of Mouse: Advances in Modelling Human Depression and Anxiety. Nat Rev Drug Discov. 2005;4:775-90. https://doi.org/10.1038/nrd1825
  43. Walsh RN, Cummim RK. The Open-Field Test a Critical Review. Psvcholoeical Bulletin. 1976;83: 482-504. https://doi.org/10.1037/0033-2909.83.3.482
  44. Sandra EF. Effects of Chlorpromazine on Exploration and Habituation in the Rat. Br J Pharmac. 1973;49:303-10. https://doi.org/10.1111/j.1476-5381.1973.tb08376.x
  45. Denenberg VH. Open-Field Behavior in the Rat: What Does It Mean? Annals of the New York Academy of Sciences (Experimental Approaches to the Study of Emotional Behavior). 1969;159: 852-9.
  46. Whimbey AE, Denenberg VH. Programming Life Histories: Creating Individual Differences by the Experimental Control of Early Experiences. Multivarious Behavior Research. 1966;1:279. https://doi.org/10.1207/s15327906mbr0103_1
  47. Whimbey AE, Denenberg VH. Experimental Programming of Life Histories: The Factor Structure Underlying Experimentally Created Individual Differences. Behaviour. 1967;29:296. https://doi.org/10.1163/156853967X00163
  48. Belzung C. Rodent Models of Anxiety-Like Behaviors: Are They Predictive for Compounds Acting Via Non-Benzodiazepine Mechanisms? Current Opinion Investigated Drugs. 2001;2:1108-11.
  49. Careau V, Olaf RP. Bininda-Emonds, et al. Are Voluntary Wheel Running and Open-Field Behavior Correlated in Mice? Different Answers from Comparative and Artificial Selection Approaches. Behav Genet. 2012;42:830-44. https://doi.org/10.1007/s10519-012-9543-0
  50. Stanford SC. The Open Field Test: Reinventing the Wheel. J Psychopharm. 2007;21:134-5. https://doi.org/10.1177/0269881107073199
  51. Kim MS, Lee CH. The Effect of Treatment with Imipramine and] or Tryptophan after Chronic Stress on the Serotonergic Immunoreactivity in Rat Raphe Nucleus. The Korean J Anat. 2002; 35(5):453-62.
  52. Clement HW, Schafer F, Ruwe C, et al. Sress Induced Changes of Extracellular 5-hydroxyindoleacetic Acid Concentrations Followed in the Nucleus Raphe Dorsalis and the Frontal Cortex of the Rat. Brain Res. 1993;614:117-24. https://doi.org/10.1016/0006-8993(93)91024-M
  53. Kim EM, Kim HR. Effect of Tryptophan on Serotonin Opiate Receptor Binding in Stressed Rats. J of Phalmacology. 1991;35(4):326-31.
  54. Maier SF, Watkins LR. Stressor Controllability and Learned Helplessness: The Roles of the Dorsal Raphe Nucleus, Serotonin, and Corticotropin- Releasing Factor. Neuroscience and Biobehavioral Reviews. 2005;29:829-41. https://doi.org/10.1016/j.neubiorev.2005.03.021
  55. Millan MJ. The Neurobiology and Control of Anxious States. Prog Neurobiol. 2003;70:83-244. https://doi.org/10.1016/S0301-0082(03)00087-X
  56. Miller GE, Chen E, Zhou ES. If It Goes Up, Must It Come Down? Chronic Stress and the Hypothalamicpituitary-Adrenocortical Axis in Humans. Psychol Bull. 2007;133:25-45. https://doi.org/10.1037/0033-2909.133.1.25
  57. Olson KL, Marc DT, Grude LA, et al. Anti-Aging Therapeutics Volume XIII, Chicago: American Academy of Anti-Aging Medicine; 2011;91-100.
  58. Heim C, Ehlert U, Hellhammer D. The Potential Role of Hypocortisolism in the Pathophysiology of Stress-Related Bodily Disorders. Psychoneuroendocrinology. 2000;25:1-35. https://doi.org/10.1016/S0306-4530(99)00035-9
  59. Gold PW, Chrousos GP. Organization of the stress system and its dysregulation in melancholic and atypical depression: High vs low CRH NE states. Molecular Psychiatry. 2002;7:254-75. https://doi.org/10.1038/sj.mp.4001032
  60. Wang R, Y Xu, HL Wu, et al. The Antidepressant Effects of Curcumin in the Forced Swimming Test Involve 5-HT1 and 5-HT2 Receptors. Eur J Pharmacol. 2008;578:43-50. https://doi.org/10.1016/j.ejphar.2007.08.045

Cited by

  1. 생쥐에서 치자시탕(梔子豉湯)의 항스트레스 효과에 대한 연구 vol.28, pp.3, 2013, https://doi.org/10.7231/jon.2017.28.3.183
  2. 기능성소화불량 환자에서 나타나는 정신적 증상의 한약 치료 : 체계적 문헌고찰과 메타분석 vol.42, pp.4, 2021, https://doi.org/10.22246/jikm.2021.42.4.488