Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin

  • Kim, Bora (Enprani Co., Ltd. R&D Center of Skin Science and Cosmetics) ;
  • Lee, Jee-Young (Bioinformatics & Molecular Design Research Center) ;
  • Lee, Ha-Yeon (Department of Genetic Engineering, Graduate School of Biotechnology and Skin Biotechnology Center, Kyung Hee University) ;
  • Nam, Ky-Youb (Bioinformatics & Molecular Design Research Center) ;
  • Park, JongIl (Department of Genetic Engineering, Graduate School of Biotechnology and Skin Biotechnology Center, Kyung Hee University) ;
  • Lee, Su Min (Enprani Co., Ltd. R&D Center of Skin Science and Cosmetics) ;
  • Kim, Jin Eun (Enprani Co., Ltd. R&D Center of Skin Science and Cosmetics) ;
  • Lee, Joo Dong (Enprani Co., Ltd. R&D Center of Skin Science and Cosmetics) ;
  • Hwang, Jae Sung (Department of Genetic Engineering, Graduate School of Biotechnology and Skin Biotechnology Center, Kyung Hee University)
  • Received : 2013.04.17
  • Accepted : 2013.08.09
  • Published : 2013.09.30
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Abstract

We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with ${\alpha}$-melanocyte stimulating hormone (${\alpha}$-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.

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References

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