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Effect of Seaweed Extract on Hair Growth Promotion in Experimental Study of C57BL/6 Mice

해조류 추출물의 발모효과에 관한 C57BL/6의 쥐 실험연구

  • Ha, Won Ho (Department of Plastic and Reconstructive Surgery, Catholic University of Daegu School of Medicine) ;
  • Park, Dae Hwan (Department of Plastic and Reconstructive Surgery, Catholic University of Daegu School of Medicine)
  • 하원호 (대구가톨릭대학교 의과대학 성형외과학교실) ;
  • 박대환 (대구가톨릭대학교 의과대학 성형외과학교실)
  • Received : 2013.01.14
  • Accepted : 2013.02.20
  • Published : 2013.04.09

Abstract

Background: Recently, substances from seaweeds have been widely used in hair growth solutions, and have been proven to be effective. Seaweeds have been documented to possess hair growth activity; however, no report on the effect of seaweed on hair regeneration has been issued to date. In this study, we investigated which exact substance of hair tonic made by JW-bio and our institute shows effects on hair growth by studying the mechanisms of candidate substances. Methods: The study was conducted to investigate the hair restoring effect of domestic natural substances; we categorized the candidate substances as seaweed, cereal, and herbal medicine. Five experimental groups were included in the study as follows: a saline group, a 50% ethanol group, seaweed group, a cereal group, and a herbal medicine group. Results: Three extracts (seaweed, cereal, and herbal medicine) were administered to C57BL/6 mice for two weeks after depilation. Depilated areas were found to be completely covered with fully grown hair, and the hair re-growth score was highest in the seaweed group. Using a hair analysis system, hair characteristics were measured in all groups on days 10 and 14 after depilation. The width and length of hair follicles were largest in the seaweed group. Groups treated with seaweed showed significantly increased gene expression of insulin-like growth factor-1. Groups treated with all the three extracts showed decreased expression of transforming growth factor-${\beta}1$. Conclusion: Findings from our study suggest that seaweeds possess hair-growth effects and may be useful for the treatment of alopecia in the future.

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