Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
권호 표지
DOI QR코드

DOI QR Code

Hepatic extraskeletal osteosarcoma with systemic metastasis in a dog

  • Johnson, Crystal (Charles River Laboratories, Inc) ;
  • Kim, Yongbaek (The Laboratory of Clinical Pathology and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University)
  • Received : 2012.10.05
  • Accepted : 2012.12.10
  • Published : 2013.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

A ten-year-old dog was presented with pancreatitis and increased hepatic enzymes. On necropsy a large firm mass was observed in the liver extending to the gall bladder. Smaller masses with similar texture were found in multiple organs including lung, stomach, pancreas, lymph nodes, omentum, and mesentery. Neoplastic cells were spindle shaped with prominent osteoid production and occasional trabeculae of woven bone. Tumor cell emboli were observed in the blood vessels and lymphatics of the omentum and stomach. Hepatic osteosarcoma with systemic metastasis is very rare and may serve to broaden the diagnostic spectrum of hepatic and pancreatic diseases in dogs.

Keywords

References

  1. Bane BL, Evans HL, Ro JY, Carrasco CH, Grignon DJ, Benjamin RS, Ayala AG. Extraskeletal osteosarcoma. A clinicopathologic review of 26 cases. Cancer 1990, 65, 2762-2770. https://doi.org/10.1002/1097-0142(19900615)65:12<2762::AID-CNCR2820651226>3.0.CO;2-K
  2. Eyre R, Feltbower RG, Mubwandarikwa E, Eden TOB, McNally RJQ. Epidemiology of bone tumours in children and young adults. Pediatr Blood Cancer 2009, 53, 941-952. https://doi.org/10.1002/pbc.22194
  3. Kirpensteijn J, Kik M, Rutteman GR, Teske E. Prognostic significance of a new histologic grading system for canine osteosarcoma. Vet Pathol 2002, 39, 240-246. https://doi.org/10.1354/vp.39-2-240
  4. Langenbach A, Anderson MA, Dambach DM, Sorenmo KU, Shofer FD. Extraskeletal osteosarcomas in dogs: a retrospective study of 169 cases (1986-1996). J Am Anim Hosp Assoc 1998, 34, 113-120. https://doi.org/10.5326/15473317-34-2-113
  5. Sordillo PP, Hajdu SI, Magill GB, Golbey RB. Extraosseous osteogenic sarcoma. A review of 48 patients. Cancer 1983, 51, 727-734. https://doi.org/10.1002/1097-0142(19830215)51:4<727::AID-CNCR2820510429>3.0.CO;2-I
  6. Valenti V, Lopez-Pousa A, Gonzalez Y, Farre N. Radiation-induced mandibular osteogenic sarcoma: report of a case and review of the literature. J Craniofac Surg 2005, 16, 452-456. https://doi.org/10.1097/01.SCS.0000147386.53251.97

Cited by

  1. Primary Exophytic Extraskeletal Osteosarcoma of the Liver: A Case Report and Literature Review vol.14, pp.None, 2021, https://doi.org/10.2147/rmhp.s296172