Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지
DOI QR코드

DOI QR Code

Cholesterol-lowering Effect of Rice Protein by Enhancing Fecal Excretion of Lipids in Rats

  • Um, Min Young (Nutrition and Metabolism Research Group, Korea Food Research Institute) ;
  • Ahn, Jiyun (Nutrition and Metabolism Research Group, Korea Food Research Institute) ;
  • Jung, Chang Hwa (Nutrition and Metabolism Research Group, Korea Food Research Institute) ;
  • Ha, Tae Youl (Nutrition and Metabolism Research Group, Korea Food Research Institute)
  • Received : 2013.05.23
  • Accepted : 2013.07.08
  • Published : 2013.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of this study was to investigate the effects of isolated protein from white rice on lipid metabolism in a hypercholesterolemic animal model. Male Sprague-Dawley rats were divided into three groups and fed either a normal diet or a high-cholesterol diet (HCD) containing either casein or isolated rice protein for 4 weeks. Compared with rats fed a HCD with casein, the total cholesterol (TC) level in the plasma was significantly reduced in the rats fed rice protein. However, no significant differences were observed in the triglycerides, high-density lipoprotein (HDL), and glucose levels among the experimental groups. Hepatic total lipids and TC levels were significantly decreased by supplementation with rice protein. In addition, rice protein significantly increased the levels of TC and bile acids in the feces. These results suggest that rice protein may improve HCD-induced hypercholesterolemia by enhancing fecal excretion of cholesterol.

Keywords

References

  1. Xie S, Zhu J, Zhang Y, Shi K, Shi Y, Ma X. 2012. Effects of soya oligosaccharides and soya oligopeptides on lipid metabolism in hyperlipidaemic rats. Br J Nutr 108: 603-610. https://doi.org/10.1017/S0007114511006015
  2. Bhuiyan MJ, Do HV, Mun S, Jun HJ, Lee JH, Kim YR, Lee SJ. 2011. Hypocholesterolemic and hypoglycemic effects of enzymatically modified carbohydrates from rice in high-fat-fed C57BL/6J mice. Mol Nutr Food Res 55: S214-S226. https://doi.org/10.1002/mnfr.201100121
  3. Hsieh CC, Hernandez-Ledesma B, de Lumen BO. 2010. Soybean peptide lunasin suppresses in vitro and in vivo 7,12-dimethylbenz[a]anthracene-induced tumorigenesis. J Food Sci 75: H311-H316. https://doi.org/10.1111/j.1750-3841.2010.01861.x
  4. Cam A, de Mejia EG. 2012. Role of dietary proteins and peptides in cardiovascular disease. Mol Nutr Food Res 56: 53-66. https://doi.org/10.1002/mnfr.201100535
  5. Morita T, Oh-hashi A, Takei K, Ikai M, Kasaoka S, Kiriyama S. 1997. Cholesterol-lowering effects of soybean, potato and rice proteins depend on their low methionine contents in rats fed a cholesterol-free purified diet. J Nutr 127: 470-477. https://doi.org/10.1093/jn/127.3.470
  6. Wofford MR, Rebholz CM, Reynolds K, Chen J, Chen CS, Myers L, Xu J, Jones DW, Whelton PK, He J. 2012. Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial. Eur J Clin Nutr 66: 419-425. https://doi.org/10.1038/ejcn.2011.168
  7. Morita T, Kiriyama S. 1993. Mass production method for rice protein isolate and nutritional evaluation. J Food Sci 58: 1393-1406. https://doi.org/10.1111/j.1365-2621.1993.tb06190.x
  8. Osada K, Inoue T, Nakamura S, Sugano M. 1999. Dietary soybean protein moderates the deleterious disturbance of lipid metabolism caused by exogenous oxidized cholesterol in rats. Biochim Biophys Acta 1427: 337-350. https://doi.org/10.1016/S0304-4165(99)00039-2
  9. Folch H, Lees M, Sloance GH. 1975. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509.
  10. Morita T, Oh-Hashi A, Kasaoka S, Ikai M, Kiriyama S. 1996. Rice protein isolates produced by the two different methods lower serum cholesterol concentration in rats compared with casein. J Sci Food Agric 71: 415-424. https://doi.org/10.1002/(SICI)1097-0010(199608)71:4<415::AID-JSFA599>3.0.CO;2-6
  11. Yang L, Chen J, Xu T, Qiu W, Zhang Y, Zhang L, Xu F, Liu H. 2011. Rice protein extracted by different methods affects cholesterol metabolism in rats due to its lower digestibility. Int J Mol Sci 12: 7594-7608. https://doi.org/10.3390/ijms12117594
  12. Yang L, Chen JH, Zhang H, Qiu W, Liu Q, Peng X, Li Y, Yang H. 2012. Alkali treatment affects in vitro digestibility and bile acid binding activity of rice protein due to varying its ratio of arginine to lysine. Food Chem 132: 925-930. https://doi.org/10.1016/j.foodchem.2011.11.068
  13. Vahouny GV, Adamson I, Chalcarz W, Satchithanandam S, Muesing R, Klurfeld DM, Tepper SA, Sanghvi A, Kritchevsky D. 1985. Effects of casein and soy protein on hepatic and serum lipids and lipoprotein lipid distributions in the rat. Atherosclerosis 56: 127-137. https://doi.org/10.1016/0021-9150(85)90013-9

Cited by

  1. Anti-inflammatory effects of egg yolk livetins (α, β, and γ-livetin) fraction and its enzymatic hydrolysates in lipopolysaccharide-induced RAW 264.7 macrophages vol.100, 2017, https://doi.org/10.1016/j.foodres.2017.07.032
  2. Therapeutic properties of rice constituents and derivatives (Oryza sativa L.): A review update vol.40, pp.1, 2014, https://doi.org/10.1016/j.tifs.2014.08.002
  3. Effect of retort sterilization on microbial safety and quality characteristics of a rice cake, songpyeon vol.25, pp.4, 2016, https://doi.org/10.1007/s10068-016-0169-5
  4. Rice endosperm protein slows progression of fatty liver and diabetic nephropathy in Zucker diabetic fatty rats vol.116, pp.08, 2016, https://doi.org/10.1017/S0007114516003512
  5. Zerumbone ameliorates high-fat diet-induced adiposity by restoring AMPK-regulated lipogenesis and microRNA-146b/SIRT1-mediated adipogenesis vol.8, pp.23, 2017, https://doi.org/10.18632/oncotarget.16974
  6. Modification of rice protein with glutaminase for improved structural and sensory properties vol.54, pp.7, 2019, https://doi.org/10.1111/ijfs.14161
  7. Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood vol.11, pp.12, 2019, https://doi.org/10.3390/nu11122919
  8. Black rice (Oryza sativa L.): A review of its historical aspects, chemical composition, nutritional and functional properties, and applications and processing technologies vol.301, pp.None, 2013, https://doi.org/10.1016/j.foodchem.2019.125304
  9. Highland Barley Whole Grain (Hordeum vulgare L.) Ameliorates Hyperlipidemia by Modulating Cecal Microbiota, miRNAs, and AMPK Pathways in Leptin Receptor-Deficient db/db Mice vol.68, pp.42, 2013, https://doi.org/10.1021/acs.jafc.0c04780
  10. Indigestible cowpea proteins reduced plasma cholesterol after long-term oral administration to Sprague-Dawley rats vol.3, pp.1, 2013, https://doi.org/10.1186/s43014-021-00061-1