Asian Pacific Journal of Cancer Prevention

  • 제14권6호
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  • Pages.3705-3709
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  • 2013
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Relationship between Epidermal Growth Factor Receptor Gene Mutations and Clinicopathological Features in Patients with Non-Small Cell Lung Cancer in Western Turkey

  • Unal, Olcun Umit (Department of Medical Oncology, Dokuz Eylul University) ;
  • Oztop, Ilhan (Department of Medical Oncology, Dokuz Eylul University) ;
  • Calibasi, Gizem (Institute of Oncology, Dokuz Eylul University) ;
  • Baskin, Yasemin (Institute of Oncology, Dokuz Eylul University) ;
  • Koca, Dogan (Department of Medical Oncology, Van Training and Research Hospital) ;
  • Demir, Necla (Department of Medical Oncology, Dokuz Eylul University) ;
  • Akman, Tulay (Department of Medical Oncology, Dokuz Eylul University) ;
  • Ellidokuz, Hulya (Institute of Oncology, Dokuz Eylul University) ;
  • Yilmaz, Ahmet Ugur (Department of Medical Oncology, Izmir University Medical Faculty)
  • 발행 : 2013.06.30
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초록

Background: To investigate epidermal growth factor receptor (EGFR) gene mutations in patients with non-small cell lung cancer (NSCLC) and to analyze any relationship with clinicopathological features and prognosis. Materials and Methods: EGFR gene exons 18-21 in 48 specimens of paraffin-embedded tumor tissue from NSCLC patients were amplified by PCR, followed by direct sequencing and analysis of links to clinicopathological features and prognosis. Results: EGFR mutations were detected in 18 of 48 (42.6%) patients with NSCLC. There were 9 cases of mutations in exon 20, 7 in exon 19 and 2 in exon 21. Mutations were more frequently observed in women (5/7 pts, 71.4%) than in men (13/41 pts, 31.7%) (p=0.086) and in non-smokers (5/5 pts, 100%) than smokers (13/43 pts, 30.2%). There was negative correlation of EGFR mutations with smoking status (p=0.005). EGFR mutations were more frequently observed with adenocarcinoma histology (13/32 pts, 40.6%) than in other types (5/16 pts, 31.3%) (p=0.527). The patients with EGFR mutations had better survival than those with wild-type EGFR (p=0.08). There was no association of EGFR mutations with metastatic spread. Conclusions: EGFR mutations in NSCLC were here demonstrated more frequently in females, non-smokers and adenocarcinoma histology in the western region of Turkey. Patients with EGFR mutations have a better prognosis.

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참고문헌

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피인용 문헌

  1. Lack of any Prognostic Role of Insulin-Like Growth Factor-1 Receptor in Non-Small Cell Lung Cancer vol.15, pp.14, 2014, https://doi.org/10.7314/APJCP.2014.15.14.5753
  2. Epidermal growth factor receptor and KRAS mutations in lung adenocarcinoma: A retrospective study of the Lebanese population vol.32, pp.5, 2014, https://doi.org/10.3892/or.2014.3406
  3. Spectrum of EGFR gene mutations and ALK rearrangements in lung cancer patients in Turkey vol.5, pp.1, 2016, https://doi.org/10.1186/s40064-016-2150-4
  4. EGFR mutation frequency in Middle East and African non-small cell lung cancer patients: a systematic review and meta-analysis vol.18, pp.1, 2018, https://doi.org/10.1186/s12885-018-4774-y
  5. Clinical significance of serum EGFR gene mutation and serum tumor markers in predicting tyrosine kinase inhibitor efficacy in lung adenocarcinoma pp.1699-3055, 2019, https://doi.org/10.1007/s12094-018-02014-6