Journal of the Korean Society of Radiology (한국방사선학회논문지)

The Korean Society of Radiology (한국방사선학회)
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Evaluation of the Radiation Dosage Flowing out of the Hot Cell During Synthesis of 18FDG

18FDG 합성시 핫셀장비 외부로 유출 방사선의 선량 평가

  • Jung, Hongmoon (Department of Radiological Science, Daegu Health College) ;
  • Cho, June ho (Department of Radiological Science, Daegu Health College) ;
  • Jung, Jaeeun (Department of nuclear medicine, yeungnam Univ. Hospital) ;
  • Won, Doyeon (Department of Radiological Science, Daegu Health College)
  • 정홍문 (대구보건대학교 방사선과) ;
  • 정재은 (대구보건대학교 방사선과) ;
  • 조준호 (케어캠프(주)-영남대학교병원) ;
  • 원도연 (대구보건대학교 방사선과)
  • Received : 2013.08.07
  • Accepted : 2013.10.25
  • Published : 2013.10.30
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Abstract

Intravenous injection is administered with radioactive medical isotopes to detect disease on Positron Emission Tomography (PET). In this case, typically, $^{18}FDG$ (Fluorodeoxyglucose) is used as a radioactive medicine. Cassette equipment is needed to synthesize deoxyglucose with $^{18}F$, produced by medical cyclotron. Production of radioactive medicine creates a lot of radiation, thus Hot Cell is used to shield a secondary radiation. We measured the radiation dosage flowing out of the hot cell during synthesis of $^{18}FDG$ or distribution. The purpose of this study is to provide the information of radiation dosage regarding the occupational exposure that unintentionally occurs during the synthesis of $^{18}FDG$. In conclusion, we confirmed the radiation dosage out of the hot cell during the $^{18}FDG$ synthesis. Especially, we observed that the radiation flowed out through the lead window, attached as a view port. Thus, it is considered that the improvement of a lead window is necessary in order to decrease the occupational exposure during the $^{18}FDG$ synthesis.

PET(positron emission tomography)을 촬영하기 위해서는 방사선 의약품 동위원소를 사용하여 인체 내에 정맥주사를 한다. 이 경우 대표적으로 사용하는 방사선 의약품은 $^{18}FDG$ (Fluorodeoxyglucose)이다. 의료용 싸이크로트론으로 생산하는 $^{18}F$에 deoxyglucose를 합성하기 위해서 합성용 카세트장치가 필요하다. 방사성 의약품 제조시에는 많은 양의 2차 방사선이 발생이 된다. 따라서 2차 방사선을 차폐하기 위하여 핫셀(Hot cell)을 사용한다. 우리는 $^{18}FDG$ 합성 또는 분배시에 핫 셀 외부로 유출되는 선량을 측정하였다. 이번 실험은 $^{18}FDG$ 제조 작업시에 의도하지 않게 발생할 수 있는 방사선 작업종사자의 피폭에 관한 선량정보를 제공하기 위함이다. 결론적으로 핫셀 내부에서 외부로 $^{18}FDG$ 합성시에 선량이 유출됨을 확인 할 수 있었다. 특히 핫셀에서 핫셀 내부를 볼 수 있는 납유리에서 외부로 방사선이 유출되는 것을 알 수 있었다. 결론적으로 $^{18}FDG$ 합성시 방사선 작업종사자의 피폭선량을 감소하기 위해서는 핫셀 존재하는 납유리의 개선점이 필요할 것으로 사료된다.

Keywords

References

  1. Chew J, Silverman DH. FDG-PET in early AD diagnosis., FDG-PET in early AD diagnosis. Med Clin North Am.,May;97(3):485-94,2013. https://doi.org/10.1016/j.mcna.2012.12.016
  2. Cabral FC, Krajewski KM, Kim KW, Ramaiya NH, Jagannathan JP., Peritoneal lymphomatosis: CT and PET/CT findings and how to differentiate between carcinomatosis and sarcomatosis.,Cancer Imaging. Apr 15;13:162-70,2013. https://doi.org/10.1102/1470-7330.2013.0018
  3. Herrera FG, Prior JO. The role of PET/CT in cervical cancer.Front Oncol. Feb 26;3:34,2013.
  4. Kim H, Frisch H, Chen CT, Genat JF, Tang F, Moses WW, et al. A Design of a PET Detector Using Micro-Channel Plate Photomultipliers with Transmission-Line Readout. Nucl Instrum Methods Phys Res A.622(3):628-636,2010. https://doi.org/10.1016/j.nima.2010.07.083
  5. Shakir DI, Okur A, Hart A, Matthies P, Ziegler SI, Essler M, et al. Towards intra-operative PET for head and neck cancer: lymph node localization using high-energy probes. Med Image Comput Comput Assist Interv.15(Pt 1):430-7, 2012.
  6. Cho IJ, Kook Dk, Ku JH, Choung WM, You GS Eun-Pyo Lee GS, et al.Evaluation on the Radiological Shielding Design of a Hot Cell Facility. J. of the Korean Radioactive Waste Society , Vol.2 No.3, 2004.
  7. Kook DH, Choung WM, Ku JH, Cho IJ,Lee EP, You GS. Radiation Dose Assessment of ACP Hotcell for Spent Fuel Treatment in Normal Operation & Accident Case. J. of the Korean Radioactive Waste Society, Vol.2 No.3,2004.
  8. Jingu K, Kaneta T, Nemoto K, Ichinose A, Oikawa M, Takai Y, et al.The utility of 18F-fluorodeoxyglucose positron emission tomography for early diagnosis of radiation-induced myocardial damage. Int J Radiat Oncol Biol Phys.Nov 1;66(3):845-51,2006. https://doi.org/10.1016/j.ijrobp.2006.06.007
  9. Iyer RB, Balachandran A, Bruzzi JF, Johnson V, Macapinlac HA, Munden RF. PET/CT and hepatic radiation injury in esophageal cancer patients. Cancer Imaging.Nov 26;7:189-94,2007. https://doi.org/10.1102/1470-7330.2007.0027

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