Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Anti-oxidant and Anti-obesity Effects of Red Pepper and Zanthoxylum schinifolium Ethanol Extract, Main Ingredient of Mara Source

마라소스 주원료인 고추 및 산초 에탄올추출물의 항산화 및 항비만 효과

  • Received : 2013.06.13
  • Accepted : 2013.07.26
  • Published : 2013.10.31
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Abstract

This study was performed to investigate anti-oxidant of red pepper and Zanthoxylum schinifolium ethanol extract, main ingredient of mara source. Anti-obesity effects of red pepper and Zanthoxylum schinifolium ethanol extract were investigated with mice fed high fat diet for 8 weeks. Sixty mice were classified to 6 groups of ND (normal diet), HFD (high fat diet), RP (high fat diet+red pepper (0.1 g/60 kg)), CP (high fat diet+Chinese pepper (0.1 g/60 kg)), RCP (high fat diet+red pepper : Chinese pepper=1:1 (0.1 g/60 kg)), HCA (high fat diet+HCA (0.1 g/60 kg)) experiments. This research showed that final weight, weight gain, food efficiency ratio, and river weight were decreased by the addition of red pepper and Zanthoxylum schinifolium ethanol extract comparing to those of HFD group. The plasma triglyceride and LDL cholesterol concentration of red pepper ethanol extract and Zanthoxylum schinifolium ethanol extract group was lower than that of high fat diet group. HDL-cholesterol concentration of red pepper ethanol extract and Zanthoxylum schinifolium ethanol extract group was higher than those of high fat diet group. These results suggested that red pepper and Zanthoxylum schinifolium ethanol extract might be useful for obesity control and good source of functional materials.

본 연구에서는 in vitro에서 중국 사천지역 고추와 산초 에탄올추출물의 항산화 효능 확인 후, 고지방식이에 의해 유도된 비만 마우스를 이용하여 중국 사천지역 고추, 산초, 고추와 산초복합물 투여 후 체중, 간과 복부 피하지방 무게, 혈중지질 함량을 측정하여 항비만 기능성 소재로서의 가능성 여부를 조사하였다. 실험군은 일반식이군, 고지방식이군, 고지방식이에 고추 및 산초, 고추와 산초복합물, HCA(hydroxyl citric acid)를 경구투여한 군의 6군으로 분류하여 8주간 사육 후, 체중, 간, 피하지방, 혈중지질 함량을 측정한 결과는 다음과 같다. 고지방식이만을 섭취한 군은 일반식이군과 비교하여 체중, 간, 복부 피하지방, 혈장지질 농도가 현저하게 증가하였다. 고지방식이에 고추와 산초 에탄올추출물을 경구투여한 군에서 8주 후 고지방군에 비해 유의적으로 체중을 감소시켰고, 복부 피하지방 양은 고지방군 3.77 g, 고추군, 산초군, 고추와 산초복합군은 각각 0.88 g, 0.9 g, 0.97 g으로 농도 의존적으로 복부 피하지방 양을 감소시켰다(P<0.05). 혈중 중성지질, 총콜레스테롤을 농도 의존적으로 감소시켜 혈액 내 지방의 축적을 저해하였고, HDL 콜레스테롤 농도가 고지방군에 비해 고추, 산초 및 고추와 산초복합군이 농도 의존적으로 증가하여(P<0.05) 조직 중의 콜레스테롤을 간으로 운반하여 콜레스테롤의 분해 및 배설을 촉진하여 조직 중의 콜레스테롤량을 감소시켜, 고추 및 산초에탄올추출물 투여가 마우스의 비만을 억제함을 확인할 수 있었다.

Keywords

References

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