DOI QR코드

DOI QR Code

Development of Photoacoustic System for Breast Cancer Detection

유방암 진단용 광음향 영상 시스템 개발

  • Lee, Soonhyouk (Department of Medical Science, School of Medicine, Ewha Womans University) ;
  • Ji, Yun-Seo (Department of Medical Science, School of Medicine, Ewha Womans University) ;
  • Lee, Rena (Department of Radiation Oncology, School of Medicine, Ewha Womans University)
  • 이순혁 (이화여자대학교 의과대학 의과학과) ;
  • 지윤서 (이화여자대학교 의과대학 의과학과) ;
  • 이레나 (이화여자대학교 의과대학 방사선종양학과)
  • Received : 2013.08.12
  • Accepted : 2013.09.04
  • Published : 2013.09.30

Abstract

Recently, the photoacoustic imaging system has been widely and intensively developed, and has been shown the possibility of diagnosis for early stage cancer. In this study, we developed a photoacoustic tomography imaging system with a commercial ultra sound device and a linear array probe. A tube phantom and a chicken breast phantom was made for the possibility of a system as a breast cancer detection. A moving average filter and a band pass filter with 3~6 MHz bandwidth were developed for background noise elimination before delay-and-sum beamforming algorithm was used for image reconstruction. As a result, we showed that some signal processing procedure before beamforming was effective for the photoacoustic image reconstruction.

광 음향 영상 장치는 최근 들어 연구와 개발이 활발히 진행 중이며 암을 조기 진단할 수 있는 장치로서의 가능성을 보이고 있다. 본 연구에서는 유방암 조기 진단을 위하여 광 음향 단층촬영 방식의 영상 장치를 개발하고 팬텀을 이용하여 그 유용성을 평가하고자 한다. 튜브 팬텀과 닭 가슴살 팬텀을 제작하고 이동 평균 필터와 3~6 MHz의 대역폭을 갖는 대역 통과 여파기를 설계하여 잡음을 제거하고 시간 지연 빔 형성(delay-and-sum beamforming) 알고리즘을 이용하여 광음향 영상을 재구성 하였다. 연구 결과 영상의 재구성에 있어서 빔 형성 알고리즘을 적용하기 전에 대역 통과 여파기와 같은 신호 처리가 효과적임을 보였다.

Keywords

References

  1. Xu M, Wang LH: Photoacoustic imaging in biomedicine. Review of Scientific Instruments 77(4):041101 (2006) https://doi.org/10.1063/1.2195024
  2. Li C, Wang LH: Photoacoustic tomography and sensing in biomedicine Phys Med Biol 54(19):59-97 (2009)
  3. Weidner N, Semple JP, Welch WR, Folkman J: Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Engl J Med 324(1):1-8 (1991) https://doi.org/10.1056/NEJM199101033240101
  4. Heijblom M, Piras D, Xia W, et al: Visualizing breast cancer using the Twente photoacoustic mammoscope: What do we learn from twelve new patient measurements? Opt Express 20(11):11582-11597 (2012) https://doi.org/10.1364/OE.20.011582
  5. 김주혜, 허장용, 오정환 등: 유방암 진단용 광음향 영상 시스템특성 평가를 위항 팬텀 개발. 의학물리 23(1):28-30 (2012)
  6. Park SH, Aglyamov SR, Emelianov SY: Beamforming for photoacoustic imaging using linear array transducer. IEEE Ultrasonics Symposium 856-859 (2007)
  7. Kruger RA, Kiser WL, Reinecke DR, Kruger GA: Thermoacoustic computed tomography using a conventional linear transducer array. Medical Physics 30(5):856-860 (2003) https://doi.org/10.1118/1.1565340
  8. Ku G, Wang X, Stoica G, Wang LH: Multiple-bandwidth photoacoustic tomography. Phys Med Biol 49(7):1329-38 (2004) https://doi.org/10.1088/0031-9155/49/7/018
  9. Duck FA: Physical Properties of Tissue. Academic Press, London (1990), pp. 120-130
  10. Wells PNT: Ultrasonic imaging of the human body. Rep Prog Phys 62(5):671 (1999) https://doi.org/10.1088/0034-4885/62/5/201