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Changing Methodologies and Reshaping Concepts in Biodiversity Science: A Historical Review of Research on Human Genetic Diversity

생물학 연구 방법론 변화에 따른 생물다양성 개념의 전환: 인간 유전다양성 연구 사례

  • Hyun, Jaehwan (Interdisciplinary Program of History and Philosophy of Science, Seoul National University)
  • 현재환 (서울대학교 과학사 및 과학철학 협동과정)
  • Received : 2014.11.24
  • Accepted : 2014.12.06
  • Published : 2014.12.31

Abstract

In order to shed some light on the historical change of biodiversity concepts, this paper reviews the science and technology studies (STS) literature on the history of biological research on human genetic diversity. By doing that, I show how the notion of genetic diversity in the human population - from "race" to "population" to "biogeographical ancestry" - has changed with methodologies and techniques over the last hundred years. In the meantime, I point out contexts and situations, despite conceptual and methodological developments, that show that current human genetic diversity research is slipping into the past mistakes of scientific racism. This article offers biodiversity researchers an opportunity to consider their own scientific practices on classifying species more reflectively.

이 글에서는 생물학적 다양성 개념의 역사적 변화를 이해할 한 가지 방안으로 인간 집단의 다양성에 대한 유전학적 연구의 역사를 탐구한 과학기술학 (STS) 연구들을 검토한다. 이를 통해, 지난 백여 년 동안 생물학 연구 방법론의 변화에 따라 인간 집단의 생물학적 다양성을 지시하는 개념의 전환이 이루어져 온 과정을 확인한다. 동시에 이 같은 연구방법과 개념의 극적인 전환에도 불구하고 최근의 인간 유전다양성 과학 역시 연구를 설계하고, 기술하며, 연구 결과를 해석하는 가운데 과거 연구들의 문제적인 가정들을 담지 하는 방향으로 미끄러질 수 있음을 지적한다. 이를 바탕으로 이 글은 생물다양성 연구자들이 개념과 연구 방법론 사이의 긴밀한 연관과 우리 시대의 종 분류 작업이 가져올 수 있는 문제들에 대해 성찰할 기회를 제공할 것이다.

Keywords

References

  1. Barkan E. 1992. The Retreat of Scientific Racism: Changing Concepts of Race in Britain and the United States Between the World Wars. Cambridge University Press, Cambridge, UK.
  2. Cann LC, Mark S and AC Wilson. 1987. Mitochondrial DNA and human evolution. Nature 325:31-36. https://doi.org/10.1038/325031a0
  3. Caspari R. 2003. From types to populations: a century of race, physical anthropology, and the American anthropological association. Am. Anthopol. 105:65-76. https://doi.org/10.1525/aa.2003.105.1.65
  4. Cavalli-Sforza LL. 2001. Genes, Peoples, and Languages. University of California Press, California.
  5. Cavalli-Sforza LL. 2005. The Human Genome Diversity Project: past, present and future. Nat. Rev. Genet. 6:334-340.
  6. Chivian E and A Bernstein eds. 2008. Sustaining Life: How Human Health Depends on Biodiversity. Oxford University Press, Oxford.
  7. Cook-Deegan R. 1994. The Gene Wars: Science, Politics, and the Human Genome. W.W. Norton & Co, New York.
  8. Daston L and P Galison. 2007. Objectivity. The MIT Press, Cambridge, MA.
  9. El-Haj NA. 2012. The Genealogical Science: The Search for Jewish Origins and the Politics of Epistemology. Chicago University Press, Chicago.
  10. Gannett L. 2001. Racism and human genome diversity research: the ethical limits of "population thinking". Philos. Sci. 68:479-486. https://doi.org/10.1086/392930
  11. Gannett L. 2014. Biogeographical ancestry and race. Stud. Hist. Philos. Biol. Biomed. Sci. 47:173-184. https://doi.org/10.1016/j.shpsc.2014.05.017
  12. Geels FW. 2002. Technological transitions as evolutionary reconfigurationprocesses: a multi-level perspective and a casestudy. Reas. Pol. 31:1257-1274. https://doi.org/10.1016/S0048-7333(02)00062-8
  13. Gieryn TF. 1983. Boundary-work and the demarcation of science from non-science: strains and interes in professional ideologies of scientists. Am. Socio. Rev. 48:781-795. https://doi.org/10.2307/2095325
  14. Hagen JB. 2010. Waiting for sequences: Morris Goodman, immunodiffusion experiments, and the origins of molecular anthropology. J. Hist. Biol. 43:697-725. https://doi.org/10.1007/s10739-009-9219-7
  15. Haraway D. 1989. Primate Visions: Gender, Race, and Nature in the World of Modern Science. Routledge, New York.
  16. Haraway D. 1997. Modest_Witness@Second_Millenium. FemaleMan_Meets_OncoMouse: Feminism and Technoscience. Routledge, New York.
  17. Herbert PDN and TR Gregory. 2005. The promise of DNA barcoding for taxonomy. Syst. Biol. 54:852-859. https://doi.org/10.1080/10635150500354886
  18. Hunt LM and N Trusedell. 2014. Observations on tenacity of racial concepts in genetics research. pp.83-106. In Anthropology of Race: Genes, Biology, and Culture. (Hartigan ed.). School for Research Press, Santa Fe, New Mexico.
  19. Huxley JS, AC Haddon and AM Carr-Saunders. 1936. We Europeans: A Survery of Racial Problems. Harper and Brothers, New York.
  20. Hyun JH. 2012. Knowledge, bodies, and identities constructed by regulation: construction of racialized body and doping regulation research in sports. Unpublished master thesis, Seoul National University. (in Korean)
  21. Hyun JH. 2014. The genomics of race and the response of science studies. Korean J. Philos. Sci. 17:83-126. (in Korean)
  22. Jorde LB, WS Watkins, MJ Mamshad, ME Dixon, CE Ricker, MT Seielstad and MA Batzer. 2000. The distribution of human genetic diversity: a comparison of mitochondrial, autosomal, and Y-chromosome data. AM. J. Hum. Genet. 66:979-988. https://doi.org/10.1086/302825
  23. Keller EF. 2010. The Mirage of a Space between Nature and Nurture. Duke University Press, Durham.
  24. Korean Association of Science and Technology Studies. 2014. An Introduction to Science and Technology Studies. Human Science Press, Seoul. (in Korean)
  25. Latour B. 1987. Science in Action: How to follow scientists and engineers through society. Harvard University Press, Cambridge, MA.
  26. Lee SS, BA Koenig and SS Richardson. 2008. Revisiting Race in a Genomic Age. Rutgers University Press, New Brunswick, NJ.
  27. Lewontin R. 1972. The apportionment of human diversity. Evol. Biol. 6:381-398.
  28. Lipphardt V. 2014. Geographical distribution patterns of various genes: genetic studies of human variation after 1945. Stud. Hist. Philos. Biol. Biomed. Sci. 47:50-61. https://doi.org/10.1016/j.shpsc.2014.05.006
  29. Little MA. 2012. Human population biology in the second half of twentieth century. Curr. Anthro. 53:126-138. https://doi.org/10.1086/663331
  30. M'Charek A. 2005. The Human Genome Diversity Project: An Ethnography of Scientific Practice. Cambridge University Press, Cambridge.
  31. Marks J. 1995. Human Biodiversity: Genes, Race, and History. Rutgers University, New Brunswick.
  32. Marks J. 1996. The legacy of serological studies in American physical anthropology. Hist. Phil. Life Sci. 18:345-362.
  33. Mayr E. 1985. The Growth of Biological Thought: Diversity, Evolution, and Inheritance. Belknap Press.
  34. Montagu A. 1951. An Introduction to Physical Anthropology (2nd ed.). Charles C. Thomas Publisher, Springfield, Illinois.
  35. Muller-Wille S and HJ Rheinberger. 2012. A Cultural History of Heredity. The Chicago University Press, Chicago.
  36. Novembre J and AD Rienzo. 2009. Spatial patterns of variation due to natural selection in humans. Nat. Rev. Genet. 10:745-755. https://doi.org/10.1038/nrg2632
  37. Prugnolle F, A Manica and F Balloux. 2004. Geography predicts neutral genetic diversity of human populations. Curr. Biol. 15:159-160.
  38. Race, Ethnicity, and Genetics Working Group (REGWG). 2005. The use of racial, ethnic, and ancestral categories in human genetics research. Am. J. Hum. Genet. 77:519-532. https://doi.org/10.1086/491747
  39. Reardon J. 2001. The Human Genome Diversity Project: a case study in coproduction. Soc. Stud. Sci. 31:357-388. https://doi.org/10.1177/030631201031003002
  40. Reardon J. 2005. Race to the Finish: Identity and Governance in an Age of Genomics. Princeton University Press, Princeton.
  41. Rosenberg NA, JK Pritchard, JL Weber, HM Cann, KK Kidd, LA Zhivotovsky and MW Feldman. 2002. Genetic structure of human populations. Science 298:2381-2385. https://doi.org/10.1126/science.1078311
  42. Sarich V and A Wilson. 1967. Immunological time scale for hominid evolution. Science 158:1200-1202. https://doi.org/10.1126/science.158.3805.1200
  43. Shriver MD and RA Kittles. 2004. Genetic ancestry and the search for personalized genetic histories. Nat. Rev. Genet. 5:611-618. https://doi.org/10.1038/nrg1405
  44. Sommer M. 2008. History in the gene: negotiations between molecular and organismal anthropology. J. Hist. Biol. 41:473-528. https://doi.org/10.1007/s10739-008-9150-3
  45. Sommer M. 2010. DNA and cultures of remembrance: Anthropological genetics, biohistories and biosocialities. Biol. Soc. 5:366-390.
  46. Sommer M. 2012. Human evolution across the disciplines: spotlights on American anthropology and genetics. Hist. Phil. Life Sci. 34:211-236.
  47. Stepan N. 1982. The Idea of Race in Science: Great Britain, 1800-1960. McMillan Press, London.
  48. Stone L and PF Lurquin. 2006. A Genetic and Cultural Odyssey: The Life and Work of L. Luca Cavalli-Sforza. Coulmbia University Press, New York.
  49. Takacs D. 1996. The Idea of Biodiversity: Philosophies of Paradise. Johns Hopkins University Press, Baltimore.
  50. Tallbear K. 2014. The emergence, politics and marketplace of Native American DNA, pp.21-37. In Routledge Handbook of Science, Technology, and Society (Kleinman DL and K Moore eds.). Routledge. New York.
  51. Washburn SL. 1951. Section of anthropology: the new physical anthropology. Trans. N. Y. Acad. Sci. 13:298-304. https://doi.org/10.1111/j.2164-0947.1951.tb01033.x
  52. Washburn SL. ed. 1964. Classification and Human Evolution. Routledge, London.
  53. Whitmarsh I and DS Jones. 2010. What's the Use of Race?: Modern Governance and the Biology of Difference. The MIT Press, Cambridge, MA.
  54. Will KW, BD Mishler and QD Wheeler. 2005. The perils of DNA barcoding and the need for integrative taxonomy. Syst. Biol. 54:844-851. https://doi.org/10.1080/10635150500354878
  55. Wilson EO. 1994. Naturalists. Warner Island Press, Wasington D.C.
  56. Zerjal T, Y Xue, G Bertorelle and RS Wells. 2003. The genetic legacy of the Mongols. Am. J. Hum. Genet. 72:717-721. https://doi.org/10.1086/367774
  57. Zuckerkandl E and L Pauling. 1962. Molecular disease, evolution and genetic heterogeneity, pp. 189-225. In Horizons in Biochemistry (Kasha M and B Pullman eds.). Academic Press.
  58. Zuckerkandl E and L Pauling. 1965. Molecules as documents of evolutionary history. J. Theoret. Biol. 8:357-366. https://doi.org/10.1016/0022-5193(65)90083-4
  59. Zuckerkandl E. 1960. A comparison of animal hemoglobins by tryptic peptide pattern analysis. Proc. Natl. Acad. Sci., 46:1349-1360. https://doi.org/10.1073/pnas.46.10.1349