대한의생명과학회지 (Biomedical Science Letters)

  • 제20권3호
  • /
  • Pages.117-123
  • /
  • 2014
  • /
  • 1738-3226(pISSN)
  • /
  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
권호 표지
DOI QR코드

DOI QR Code

The Ameliorative Effect of Adenophorae Radix on Atopic Dermatitis in vivo and in vitro

  • Jung, Ji-Wook (Department of Herbal Medicinal Pharmacology, College of Herbal Bio-industry, Daegu Haany University) ;
  • Kim, Su-Jin (Department of Herbal Medicinal Pharmacology, College of Herbal Bio-industry, Daegu Haany University)
  • 투고 : 2014.05.13
  • 심사 : 2014.09.08
  • 발행 : 2014.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Adenophorae Radix (AR) has been used as a traditional medicine for various diseases. However, the regulatory effects of AR in atopic dermatitis are not yet understood. This study attempted to determine the pharmacological effects of AR and its constituent on both compound 48/80 or histamine-induced scratching behaviors and 2, 4-dinitrochlrobenzene (DNCB)-induced atopic dermatitis in mice. The findings of this study demonstrated that AR reduced compound 48/80 or histamine-induced scratching behaviors in mice. Treatment of AR attenuated the AD symptoms such as eczematous, erythema and dryness and serum IgE and IL-6 levels in AD model. Additionally, AR inhibited the TNF-${\alpha}$-induced the Nuclear factor-${\kappa}B$ activation in HaCaT cells. Collectively, the findings of this study provide us with novel insights into the pharmacological actions of AR as a potential molecule for therapeutic agent against atopic dermatitis.

키워드

참고문헌

  1. Allam JP, Novak N. The pathophysiology of atopic eczema. Clin Exp Dermatol. 2006. 31: 89-93. https://doi.org/10.1111/j.1365-2230.2005.01980.x
  2. Brenninkmeijer EE, Spuls PI, Legierse CM, Lindeboom R, Smitt JH, Bos JD. Clinical differences between atopic and atopiform dermatitis. J Am Acad Dermatol. 2008. 58: 407-414. https://doi.org/10.1016/j.jaad.2007.12.002
  3. Berke R, Singh A, Guralnick M. Atopic dermatitis: an overview. Am Fam Physician. 2012. 86: 35-42.
  4. Buske-Kirschbaum A, Geiben A, Hellhammer D. Psychobiological aspects of atopic dermatitis: an overview. Psychother Psychosom. 2001. 70: 6-16. https://doi.org/10.1159/000056219
  5. Chan BC, Hon KL, Leung PC, Sam SW, Fung KP, Lee MY, Lau HY. Traditional Chinese medicine for atopic eczema: Penta-Herbs formula suppresses inflammatory mediators release from mast cells. J Ethnopharmacol. 2008. 120: 85-91. https://doi.org/10.1016/j.jep.2008.07.034
  6. Choi JH, Jin SW, Park BH, Kim HG, Khanal T, Han HJ, Hwang YP, Choi JM, Chung YC, Hwang SK, Jeong TC, Jeong HG. Cultivated ginseng inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-$\alpha$/IFN-$\gamma$-induced TARC activation in HaCaT cells. Food Chem Toxicol. 2013. 56: 195-203. https://doi.org/10.1016/j.fct.2013.02.037
  7. Eichenfield LF, Ellis CN, Mancini AJ, Paller AS, Simpson EL. Atopic dermatitis: epidemiology and pathogenesis update. Semin Cutan Med Surg. 2012. 31: 3-5. https://doi.org/10.1016/S1085-5629(12)00127-7
  8. TD, Garbati MR. Inhibition of NF-${\kappa}B$ signaling as a strategy in disease therapy. Curr Top Microbio Immunol. 2011. 349: 245-263.
  9. Gold MS, Kemp AS. Atopic disease in childhood. Med J Aust. 2005. 182: 298-304.
  10. Homey B, Steinhoff M, Ruzicka T, Leung DY. Cytokines and chemokines orchestrate atopic skin inflammation. J Aller Clin Immunol. 2006. 118: 178-189. https://doi.org/10.1016/j.jaci.2006.03.047
  11. Leung DY, Bieber T. Atopic dermatitis. Lancet. 2003. 361: 151-160. https://doi.org/10.1016/S0140-6736(03)12193-9
  12. Lee CS, Jeong EB, Kim YJ, Lee MS, Seo SJ, Park KH, Lee MW. Quercetin-3-O-(2"-galloyl)-$\alpha$-l-rhamnopyranoside inhibits TNF-$\alpha$-activated NF-${\kappa}B$-induced inflammatory mediator production by suppressing ERK activation. Int Immunopharmacol. 2013. 16: 481-487. https://doi.org/10.1016/j.intimp.2013.05.001
  13. Minami K, Kamei CA. chronic model for evaluating the itching associated with allergic conjunctivitis in rats. Int Immunopharmacol. 2004. 4: 101-108. https://doi.org/10.1016/j.intimp.2003.10.013
  14. Roh SS, Kim SH, Lee YC, Seo YB. Effects of radix adenophorae and cyclosporine A on an OVA-induced murine model of asthma by suppressing to T cells activity, eosinophilia, and bronchial hyperresponsiveness. Mediators Inflamm. 2008: 781425.
  15. Schoonbroodt S, Legrand-Poels S, Best-Belpomme M, Piette J. Activation of the NF-kappaB transcription factor in a Tlymphocytic cell line by hypochlorous acid. Biochem J. 1997. 321: 777-785. https://doi.org/10.1042/bj3210777
  16. Shiohara T, Hayakawa J, Mizukawa Y. Animal models for atopic dermatitis: are they relevant to human disease?. J Dermatol Sci. 2004. 36: 1-9. https://doi.org/10.1016/j.jdermsci.2004.02.013
  17. Sugimoto Y, Umakoshi K, Nojiri N, Kamei C. Effect of histamine H1 receptor antagonists on compound 48/80-induced scratching behavior in mice. Eur J Pharmacol. 1998. 351: 1-5. https://doi.org/10.1016/S0014-2999(98)00288-X
  18. Yang G, Choi CH, Lee K, Lee M, Ham I, Choi HY. Effects of Catalpa ovata stem bark on atopic dermatitis-like skin lesions in NC/Nga mice. J Ethnopharmacol. 2013. 30: 145: 416-423.
  19. Vestergaard C, Bang K, Gesser B, Yoneyama H, Matsushima K, Larsen CG. A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+lymphocytes into lesional atopic dermatitis skin. J Invest Dermatol. 2000. 115: 640-646. https://doi.org/10.1046/j.1523-1747.2000.00115.x
  20. Zhang M, Zhou J, Wang L, Li B, Guo J, Guan X, Han Q, Zhang H. Caffeic acid reduces cutaneous tumor necrosis factor alpha (TNF-$\alpha$), IL-6 and IL-$1{\beta}$ levels and ameliorates skin edema in acute and chronic model of cutaneous inflammation in mice. Biol Pharm Bull. 2014. 37: 347-354. https://doi.org/10.1248/bpb.b13-00459