대한의생명과학회지 (Biomedical Science Letters)

  • 제20권3호
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  • Pages.156-161
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  • 2014
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
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Effects of Dietary from Safflower Bud on the Osteoporosis in Ovariectomized Rats

  • Lim, Seul Ki (Metabolism and Functionality Research Group, R & D division, World Institute of Kimchi) ;
  • Kim, Dong Il (Department of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University) ;
  • Park, Min Jung (Department of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University) ;
  • Choi, Joo Hee (Department of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Young Kuk (R&D Team, Dasan Institute of Life & Science Co., Ltd.) ;
  • Lee, An Chul (R&D Team, Dasan Institute of Life & Science Co., Ltd.) ;
  • Choi, Mi Young (R&D Team, Dasan Institute of Life & Science Co., Ltd.) ;
  • Park, Soo Hyun (Department of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University)
  • 투고 : 2014.08.25
  • 심사 : 2014.09.29
  • 발행 : 2014.09.30
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초록

It has been reported that safflower seeds have preventive effects against osteoporosis. Recently, safflower buds (SB) were found to have more useful functional ingredients than safflower seeds. In the current study, we evaluated the anti-osteoporosis effects of SB diet in ovariectomized (OVX) rats. The rats were divided into five groups; sham operated group, OVX alone group, OVX plus $17{\beta}$-estradiol ($E^2$ $10{\mu}g/kg$, i.p.) and OVX plus SB diet feeding group (0.3% or 1%). Feeding of SB diet (0.3% or 1%) to OVX rats markedly increased bone mineral density (BMD) of femurs, compared to the OVX group. The OVX rats exhibited a marked increase in trabecular separation (Tb.Sp) and this change was inhibited by the feeding of SB diet, similar to that seen with OVX+E2 group. Moreover, feeding of SB diet to OVX rats decreased the markers of bone turnover, including osteocalcin and alkaline phosphatase (ALP). These results suggest that SB extract has a bone sparing effect in OVX-induced trabecular bone loss and prevents deterioration of bone microarchitecture by suppressing the rate of bone turnover. Therefore, SB may be useful for preserving bone mass and structure in estrogen deficient women with a potential role in reducing postmenopausal osteoporosis.

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참고문헌

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