Asian Pacific Journal of Cancer Prevention

  • 제15권22호
  • /
  • Pages.9621-9625
  • /
  • 2014
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

XRCC3 Thr241Met Gene Polymorphism and Risk of Colorectal Cancer in Kashmir: a Case Control Study

  • Nissar, Saniya (Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences) ;
  • Sameer, Aga Syed (Department Biochemistry, Sher-I-Kashmir Institute of Medical Sciences Associated Medical College) ;
  • Lone, Tufail A. (Department General Surgery, Sher-I-Kashmir Institute of Medical Sciences) ;
  • Chowdri, Nissar A. (Department General Surgery, Sher-I-Kashmir Institute of Medical Sciences) ;
  • Rasool, Roohi (Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences)
  • 발행 : 2014.12.18
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

XRCC (X-ray cross-complementing group) genes contribute to important DNA repair mechanisms that play roles in the repair of single strand breaks (SSBs) induced by a variety of external and internal factors, including ionizing radiation, alkylating agents and reactive oxygen species. These repair genes have a pivotal role in maintaining genomic stability through different pathways of base excision repair (BER). The aim of this study was to investigate the XRCC3 Thr241Met gene polymorphism in colorectal cancer (CRC) in Kashmir. We investigated the genotype distribution of XRCC3 gene in 120 CRC cases in comparison with 150 healthy subjects and found a significant association between XRCC3 genotypes and CRC ($p{\leq}0.05$). Both heterozygous genotype (Thr/Met) as well as homozygous variant genotype (Met/Met) were moderately associated with elevated risk of CRC [OR=2.53; OR=2.29 respectively]. Also, Thr/Met and Met/Met genotypes demonstrated a significant association with the risk of CRC (p = 0.003). This study displayed a significantly elevated risk for CRC in individuals with XRCC3 Thr/Met and Met/Met Genotype of about 2.5 times that with the Thr/Thr wild genotype.

키워드

참고문헌

  1. Berwick M, Vineis P (2000). Markers of DNA repair and susceptibility in humans: an epidemiological review. J Natl Cancer Inst, 91, 874-97.
  2. Bishop DK, Ear U, Bhattacharya A, et al (1998). XRCC3 is required for assembly of Rad51 complexes in vivo. J Biol Chem, 273, 21482-8. https://doi.org/10.1074/jbc.273.34.21482
  3. Blankenburg S, Konig IR, Moessner R, et al (2005). Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study. Carcinogenesis, 26, 1085-90. https://doi.org/10.1093/carcin/bgi055
  4. Christmann M, Tomicic MT, Roos WP, Kaina B (2003). Mechanisms of human DNA repair: an update. Toxicology, 193, 3-34. https://doi.org/10.1016/S0300-483X(03)00287-7
  5. Deans B, Griffin CS, O'regan P, Jasin M, Thacker J (2003). Homologous recombination deficiency leads to profound genetic instability in cells derived from Xrcc2-knockout mice. Cancer Res, 63, 8181-7.
  6. Gellad ZF, Provenzale D (2010). Colorectal cancer: national and international perspective on the burden of disease and public health impact. Gastroenterology, 138, 2177-90. https://doi.org/10.1053/j.gastro.2010.01.056
  7. Goode EL, Ulrich CM, Potter JD (2002). Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol Biomarkers Prev, 11, 1513-30.
  8. Griffin CS (2002). Aneuploidy, centrosome activity and chromosome instability in cells deficient in homologous recombination repair. Mutat Res, 504, 149-55. https://doi.org/10.1016/S0027-5107(02)00088-X
  9. Jacobsen NR, Raaschou-Nielsen O, Nexo B, et al (2004). XRCC3 polymorphisms and riskof lung cancer. Cancer Lett, 213, 67-72. https://doi.org/10.1016/j.canlet.2004.04.033
  10. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  11. Jin MJ, Chen K, Song L, et al (2005). The association of the DNA repair gene XRCC3 Thr241Met polymorphism with susceptibility to colorectal cancer in a Chinese population. Cancer Gen Cytogen, 163, 38-43. https://doi.org/10.1016/j.cancergencyto.2005.05.001
  12. Kowalska-Loth B, Bubko I, Komorowska B, Szumiel I, Staron K (1998). Contribution of topoisomerase I to conversion of single strand into double-strand DNA breaks. Mol Biol Rep, 25, 21-6. https://doi.org/10.1023/A:1006831527609
  13. Krupa R, Sliwinski T, Wisniewska-Jarosinska M, et al (2011). Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer-a case control study. Mol Biol Rep, 38, 2849-54. https://doi.org/10.1007/s11033-010-0430-6
  14. Matullo G, Guarrera S, Carturan S, et al (2001a). DNA repair gene polymorphisms,bulky DNA adducts in white blood cells and bladder cancer in a case-control study. Int J Cancer, 92, 562-7. https://doi.org/10.1002/ijc.1228
  15. Matullo G, Palli D, Peluso M, et al (2001b). XRCC1, XRCC3, XPD gene polymorphisms, smoking and 32P-DNA adducts in a sample of healthy subjects. Carcinogenesis, 22, 1437-45. https://doi.org/10.1093/carcin/22.9.1437
  16. Mort R, McEwan C, Melton DW (2003). Lack of involvement of nucleotide excision repair gene polymorphisms in colorectal cancer. Br J Cancer, 89, 333-7. https://doi.org/10.1038/sj.bjc.6601061
  17. Nassiri M, Kooshyar MM, Roudbar Z, Mahdavi M, Doosti M (2013). Genes and SNPs associated with non-hereditary and hereditary colorectal cancer. Asian Pac J Cancer Prev, 14, 5609-14. https://doi.org/10.7314/APJCP.2013.14.10.5609
  18. Nissar S, Lone TA, Banday MZ, et al (2013). XRCC1 Arg 399 Gln polymorphism and risk of colorectal cancer: a case control study in Kashmiri Population. Oncol Lett, 5, 959-63.
  19. Nissar S, Sameer AS, Rasool R, Rashid F (2014). DNA Repair Gene-XRCC1 in relation to genome instability and role in colorectal carcinogenesis. Oncol Res Treat, 37, 004.
  20. Rasool MT, Lone MM, Wani ML, (2012). Cancer in kashmir, India: burden and pattern of disease. J Can Res Ther, 8, 243-46. https://doi.org/10.4103/0973-1482.98978
  21. Ryk C, Kumar R, Thirumaran RK, Hou SM (2006). Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers. Lung Cancer, 54, 285-92. https://doi.org/10.1016/j.lungcan.2006.08.004
  22. Sameer AS (2013). Colorectal cancer: a researcher's perspective of the Molecular Angel's gone eccentric in the vale of Kashmir. Tumor Biology, 34, 1301-5. https://doi.org/10.1007/s13277-013-0692-4
  23. Skjelbred CF, Saebo M, Wallin H, et al (2006). Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study. BMC Cancer, 16, 67.
  24. Smilenov LB (2006). Tumor development: haplo-insufficiency and local network assembly. Cancer Lett, 240, 17-28. https://doi.org/10.1016/j.canlet.2005.08.015
  25. Smith TR, Miller MS, Lohman K, et al (2003). Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer. Cancer Lett, 190, 183-90. https://doi.org/10.1016/S0304-3835(02)00595-5
  26. Stern MC, Siegmund KD, Corral R, Haile RW (2005). XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk. Cancer Epidemiol Biomarkers Prev, 14, 609-15. https://doi.org/10.1158/1055-9965.EPI-04-0189
  27. Takata M, Sasaki MS, Tachiiri S, et al (2001). Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs. Mol Cell Biol, 21, 2858-66. https://doi.org/10.1128/MCB.21.8.2858-2866.2001
  28. Tebbs RS, Zhao Y, Tucker JD, et al (1995). Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene. Proc Natl Acad Sci USA, 92, 6354-8. https://doi.org/10.1073/pnas.92.14.6354
  29. Thacker J (2005). The RAD51 gene family, genetic instability and cancer. Cancer Lett, 219, 125-35. https://doi.org/10.1016/j.canlet.2004.08.018
  30. Tranah GJ, Giovannucci E, MaJ, et al (2004). XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev, 13, 1090-1.
  31. Winsey SL, Haldar NA, Marsh HP, et al (2000). A variant within the with the development of melanoma skin cancer. Cancer Res, 60, 5612-6.
  32. Yeh CC, Sung FC, Tang R, Chang-Chieh CR, Hsieh LL (2005). Polymorphisms of the XRCC1, XRCC3, & XPD genes, and colorectal cancer risk: a case-control study in Taiwan. BMC Cancer, 5, 12. https://doi.org/10.1186/1471-2407-5-12
  33. Zhao Y, Deng X, Wang Z, Wang Q, Liu Y (2012). Genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 and risk of colorectal cancer in Chinese population. Asian Pac J Cancer Prev, 13, 665-9. https://doi.org/10.7314/APJCP.2012.13.2.665
  34. Zienolddiny S, Campa D, Lind H, et al (2006). Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. Carcinogenesis, 27, 560-7. https://doi.org/10.1093/carcin/bgi232

피인용 문헌

  1. Association between the XRCC3 Thr241Met Polymorphism and Risk of Colorectal Cancer: a Meta Analysis of 5,193 Cases and 6,645 Controls vol.16, pp.6, 2015, https://doi.org/10.7314/APJCP.2015.16.6.2263
  2. Analysis of XRCC2 and XRCC3 gene polymorphisms in pancreatic cancer vol.4, pp.2, 2015, https://doi.org/10.3892/br.2015.550
  3. The Association of Low-Penetrance Variants in DNA Repair Genes with Colorectal Cancer: A Systematic Review and Meta-Analysis vol.8, pp.7, 2017, https://doi.org/10.1038/ctg.2017.35