DOI QR코드

DOI QR Code

Clinical Features of Patients with Esophageal and Second Primary Cancers

  • Tsai, Huang-Wen (Department of General Surgery, Far Eastern Memorial Hospital) ;
  • Chang, Chih-Chun (Department of Clinical Pathology, Far Eastern Memorial Hospital) ;
  • Sun, Jen-Tang (Department of Emergency, Far Eastern Memorial Hospital) ;
  • Liou, Ching-Biau (Department of Clinical Pathology, Far Eastern Memorial Hospital) ;
  • Lin, Hsiu-Chen (Department of Clinical Pathology, Far Eastern Memorial Hospital) ;
  • Lin, I-Hsin (Department of Clinical Pathology, Far Eastern Memorial Hospital) ;
  • Yu, Yun-Chieh (Department of Clinical Pathology, Far Eastern Memorial Hospital) ;
  • Weng, Wei-Ling (Department of Clinical Pathology, Far Eastern Memorial Hospital) ;
  • Leong, Ka-I (Department of Chest Surgery, Far Eastern Memorial Hospital) ;
  • Yen, Tzung-Hai (Division of Nephrology and Clinical Toxicology, Chang Gung Memorial Hospital, Lin-Kou Medical Center) ;
  • Wu, Jiann-Ming (Department of General Surgery, Far Eastern Memorial Hospital)
  • 발행 : 2014.12.18

초록

Background: The prevalence of esophageal cancer (EC) with second primary cancers (SPC) is increasing worldwide. This study was aimed to understand the clinical features of EC patients with SPC in the Taiwanese population. Materials and Methods: Clinical and laboratory data for 180 EC patients with or without SPC were collected between January 2009 and December 2013. Information on treatment approaches, location of SPCs and ABO blood type were also collected and stratified. Results: The most common SPC in EC patients was hypopharyngeal cancer, followed by laryngeal cancer and hepatocellular carcinoma in our study. Malignancies of colon, prostate and lung were also found. There was a significant higher portion of blood type A in the EC patients with SPC compared with those without (42.4% vs 19.5%, P=0.006). Conclusions: The frequency and SPC site distribution and blood type A should be considered in clinical evaluation of EC patients with a high risk of developing SPC in the Taiwanese population.

키워드

참고문헌

  1. Caygill CP, Royston C, Charlett A, et al (2011). Barrett's, blood groups and progression to oesophageal cancer: is nitric oxide the link? Eur J Gastroenterol Hepatol, 23, 801-6. https://doi.org/10.1097/MEG.0b013e3283489dcf
  2. Das A, Thomas S, Zablotska LB, et al (2006). Association of esophageal adenocarcinoma with other subsequent primary cancers. J Clin Gastroenterol, 40, 405-11. https://doi.org/10.1097/00004836-200605000-00008
  3. Ge L, Wang HJ, Yin D, et al (2012). Effectiveness of 5-flurouracil-based neoadjuvant chemotherapy in locallyadvanced gastric/gastroesophageal cancer: a meta-analysis. World J Gastroenterol, 18, 7384-93. https://doi.org/10.3748/wjg.v18.i48.7384
  4. Gursel B, Meydan D, Ozbek N, et al (2011). Multiple primary malignant neoplasms from the Black sea region of Turkey. J Int Med Res, 39, 667-74. https://doi.org/10.1177/147323001103900237
  5. Jingu K, Matsushita H, Takeda K, et al (2012). Long-term results of radiotherapy combined with nedaplatin and 5-fluorouracil for postoperative loco-regional recurrent esophageal cancer: update on a phase II study. BMC Cancer, 12, 542. https://doi.org/10.1186/1471-2407-12-542
  6. Jemal A, Siegel R, Ward E, et al (2009). Cancer statistics, 2009. CA Cancer J Clin, 59, 225-49. https://doi.org/10.3322/caac.20006
  7. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  8. Lawniczak M, Gawin A, Jaroszewicz-Heigelmann H, et al (2014). Synchronous and metachronous neoplasms in gastric cancer patients: a 23-year study. World J Gastroenterol, 20, 7480-7. https://doi.org/10.3748/wjg.v20.i23.7480
  9. Luciani A, Ascione G, Marussi D, et al (2009). Clinical analysis of multiple primary malignancies in the elderly. Med Oncol, 26, 27-31. https://doi.org/10.1007/s12032-008-9075-x
  10. Mao WM, Zheng WH, Ling ZQ (2012). Epidemiologic risk factors for esophageal cancer development. Asian Pac J Cancer Prev, 12, 2461-6.
  11. Matsubara T, Yamada K, Nakagawa A, et al (2003). Risk of second primary malignancy after esophagectomy for squamous cell carcinoma of the thoracic esophagus. J Clin Oncol, 21, 4336-41. https://doi.org/10.1200/JCO.2003.12.074
  12. Newhauser WD, Fontenot JD, Mahajan A, et al (2009). The risk of developing a second cancer after receiving craniospinal proton irradiation. Phys Med Biol, 54, 2277-91. https://doi.org/10.1088/0031-9155/54/8/002
  13. Pandeya N, Olsen CM, Whiteman DC, et al (2013). Sex differences in the proportion of esophageal squamous cell carcinoma cases attributable to tobacco smoking and alcohol consumption. Cancer Epidemiol, 37, 579-84. https://doi.org/10.1016/j.canep.2013.05.011
  14. Poon RT, Law SY, Chu KM, et al (1998). Multiple primary cancers in esophageal squamous cell carcinoma: incidence and implications. Ann Thorac Surg, 65, 1529-34. https://doi.org/10.1016/S0003-4975(98)00177-5
  15. Prabhu A, Obi KO, Rubenstein JH et al (2014). The synergistic effects of alcohol and tobacco consumption on the risk of esophageal squamous cell carcinoma: a meta-analysis. Am J Gastroenterol, 109, 822-7. https://doi.org/10.1038/ajg.2014.71
  16. Sachs RK, Shuryak I, Brenner D, et al (2007). Second cancers after fractionated radiotherapy: stochastic population dynamics effects. J Theor Biol, 49, 518-31.
  17. Song QK, Li J, Jiang HD, et al (2012). Esophageal cancer mortality during 2004-2009 in Yanting County, China. Asian Pac J Cancer Prev, 13, 5003-6. https://doi.org/10.7314/APJCP.2012.13.10.5003
  18. Sun P, Chen C, Zhang F, et al (2014). The ABO blood group predicts survival in esophageal squamous cell carcinoma in patients who ever smoked: a retrospective study from China. Tumour Biol, 35, 7201-8. https://doi.org/10.1007/s13277-014-1960-7
  19. Takalkar U, Asegaonkar BN, Kodlikeri P, et al (2013). An elderly woman with triple primary metachronous malignancy: A case report and review of literature. Int J Surg Case Rep, 4, 593-6. https://doi.org/10.1016/j.ijscr.2013.03.032
  20. Tang WR, Fang JY, Wu KS, et al (2014). Epidemiological characteristics and prediction of esophageal cancer mortality in China from 1991 to 2012. Asian Pac J Cancer Prev, 15, 6929-34. https://doi.org/10.7314/APJCP.2014.15.16.6929
  21. Travis LB, Demark Wahnefried W, Allan JM, et al (2013). Aetiology, genetics and prevention of secondary neoplasms in adult cancer survivors. Nat Rev Clin Oncol, 10, 289-301 https://doi.org/10.1038/nrclinonc.2013.41
  22. Warren S, Gates O (1932). Multiple primary malignant tumors: a survey of the literature and statistical study. Am J Cancer, 16, 1358-414.
  23. Wood ME, Vogel V, Ng A, et al (2012). Second malignant neoplasms: Assessment and strategies for risk reduction. J Clin Oncol, 30, 3734-45. https://doi.org/10.1200/JCO.2012.41.8681
  24. Zhang Y (2013). Epidemiology of esophageal cancer. World J Gastroenterol, 19, 5598-606. https://doi.org/10.3748/wjg.v19.i34.5598
  25. Zhu G, Chen Y, Zhu Z, et al (2012). Risk of second primary cancer after treatment for esophageal cancer: a pooled analysis of nine cancer registries. Disease Esophagus, 25, 505-11. https://doi.org/10.1111/j.1442-2050.2011.01273.x

피인용 문헌

  1. Creatine Kinase (CK)-MB-to-Total-CK Ratio: a Laboratory Indicator for Primary Cancer Screening vol.16, pp.15, 2015, https://doi.org/10.7314/APJCP.2015.16.15.6599