Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effects of short-term supplementation of erythritol-salt on urinary electrolyte excretion in rats

단기간의 에리스리톨 소금 섭취가 흰쥐의 요 중 전해질 배출에 미치는 영향

  • 경명옥 (대한제당(주) 중앙연구소) ;
  • 임지예 (이화여자대학교 식품영양학과) ;
  • 이경선 (대한제당(주) 중앙연구소) ;
  • 정상원 (대한제당(주) 중앙연구소) ;
  • 최근범 (대한제당(주) 중앙연구소) ;
  • 양창근 ((주)TS 푸드앤시스템) ;
  • 김유리 (이화여자대학교 식품영양학과)
  • Received : 2013.02.24
  • Accepted : 2014.04.10
  • Published : 2014.04.30
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Abstract

Purpose: This study was conducted in order to investigate the diuretic effects of Erythritol (ET) salt on urinary electrolyte excretion in Sprague-Dawley Rats. Methods: Animals were divided into two groups: Salt group (n = 7) and Salt + ET fed group (n = 7). Animals were provided food and water ad libitum. Supplements were administered orally to animals for one week. Results: Body weights were not statistically different between groups either on Day 1 or Day 7. However, water consumption of the Salt + ET group was significantly higher than that of the Salt group on Day 1 and Day 7. Urine volume of the Salt + ET group was approximately 27% and 38% higher than that of the Salt group on Day 1 and Day 7. In addition, we found that the total amounts of urinary electrolytes, such as sodium and potassium, of the Salt + ET group were significantly higher than those of the Salt group on Day 7. We also found that serum electrolyte concentrations did not differ between two groups. These results demonstrated that salt intake with ET was effective in increasing urinary electrolyte excretion, which might be caused by higher water intake and diuretic effect inhibiting reabsorption of water, sodium, and potassium in renal tubules. Conclusion: The results suggest that short-term supplementation of ET salt can be a potential diuretic agent by inhibiting sodium and potassium reabsorption and inducing loss of water.

본 연구는 ET가 함유된 소금의 섭취가 요를 통한 나트륨 배출에 미치는 단기간의 효과를 확인하기 위하여 연구를 수행하였다. 실험기간 동안 일반소금을 섭취한 대조군, ET가 함유된 소금을 섭취한 실험군 Salt + ET에서 식이섭취 및 체중증가는 Day 7에는 통계적으로 유의적인 차이가 없었으나 물 섭취량은 Day 1과 Day 7에서 모두 Salt + ET에서 높은 경향을 보였다. 요량을 측정한 결과 Salt와 비교하여 ET를 섭취한 Salt + ET에서 약 27% 높았으며 Day 1과 Day 7에서 모두 통계적으로 유의적인 증가가 관찰되었다 (p < 0.05). 시험기간 동안 요를 통해 배출된 총 나트륨과 칼륨의 양을 산출한 결과 ET를 섭취한 Salt + ET에서 1일차와 7일차에 모두 높게 나타났으며, 특히 7일차에 ET를 섭취한 Salt + ET에서 유의적으로 증가하였다(p < 0.01). 혈중 나트륨 농도와 칼륨 농도에서는 두 그룹간 유의적인 차이가 없었다. 이러한 결과들을 종합하여 볼 때 단기간의 ET 섭취에도 ET의 이뇨작용으로 인한 요량의 증가를 통해 전해질 배출에 도움을 줄 수 있으며 부작용이 많은 이뇨제들 대신으로 쓰일 수 있는 이뇨제 역할을 할 수 있을 것으로 사료되며, 향후 더 많은 연구와 분석들을 통해 혈압 강하제의 잠재적인 효과도 기대할 수 있을 것으로 사료된다.

Keywords

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