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An Analysis on Prevalence and Allergen of Food Allergies

식품 알레르기의 유병률과 알레르겐 분석

  • Received : 2013.11.13
  • Accepted : 2014.02.26
  • Published : 2014.03.31

Abstract

Objectives: The purpose of this study was to estimate the prevalence of food allergies and find out food allergens. Methods: Questionnaires were completed by 2,415 subjects in D city, among whom 452 subjects believed that they had food allergy. Skin prick tests were performed on these subjects. The data were analyzed using SAS Version 9.0 and ${\chi}^2$-test. In addition, several recent studies were reviewed. Results: The prevalence rate of food allergic symptoms was 25.6% in males and 25.8% in females, respectively. The positive rate of skin prick tests among those who were allergic to any of 14 food items was 21.4% in males and 14.7% in females(p=0.018). Therefore, it was estimated that the prevalence rate of food allergy was 5.0% in males and 3.6% in females. It was shown that the major food allergens were hop, shrimp, lobster, oyster and egg(whole) in males, and egg(whole), hop, oyster, and pork in females, respectively. The prevalence in recent studies ranged from 1 to 35%. Major food allergens were milk, egg, nuts, fish, shellfish crustacean and fruits/vegetables. Conclusions: In order to provide effective care for food allergy, it is essential to find out the prevalence of food allergies and food allergens.

식품 알레르기에 대한 유병률과 알레르기를 일으키는 식품의 종류를 알아내기 위해, 설문지 조사와 피부단자시험을 실시하였고, 또한 최근 국내외 식품 알레르기에 대한 자료 고찰을 하였다. 본 연구결과 설문지에 의한 성별 식품 알레르기 증상 유병률은 남자에서는 25.6%, 여자는 25.8%로 남녀 간에 별 차이가 없었으며, 연령별로는 남자는 40-49세가 31.8%, 여자에서는 30-39세가 32.6%로 가장 높았다. 성별과 식품 항목에 의한 식품 알레르기의 유병률은 남자는 고등어가 6.6%로 가장 높았고, 여자는 복숭아가 7.4%로 가장 높았다. 성별에 의한 식품 알레르기 증상 유병자 중 피부단자시험 양성률을 보면 남자에서 21.4%의 양성률을, 여자에 있어서는 14.7%의 양성률을 나타내 남녀간의 유의한 차이(p=0.018)가 있었다. 식품 항목별 양성률을 보면 남자에서는 호프가 58.9%로 가장 높았고, 여자에서는 계란이 36.4%로 가장 높은 양성률을 나타냈으며, 돼지고기, 새우 가재, 호프, 그리고 토마토에서 통계적으로 남녀 간 유의한 차이가 있었다(p<0.05). 피부단자시험을 통하여 우리나라 식품 알레르기 증상 추정 유병률은 남자 5.0%, 여자 3.6%였으며, 알레르기를 일으키는 흔한 식품으로는 호프, 고등어, 새우, 가재, 게, 돼지고기, 우유, 계란 등이 포함된다고 생각한다. 최근 국내외 식품 알레르기에 관한 자료 분석에서 식품 알레르기 유병률은 1-35% 범위로 나타났으며, 알레르기를 일으키는 주요 식품은 우유, 계란, 견과류, 생선, 조개, 갑각류 그리고 과일 채소 등으로 확인 하였다. 따라서 본 연구는 지역사회 전 연령층을 대상으로 그리고 최근 국내외 식품 알레르기에 관한 자료를 분석한 첫 시도로써 향후 우리나라 식품 알레르기 질환을 예방하고 치료하는데 근거자료의 토대가 될 것이다. 또한 식품 알레르기 교육프로그램을 계획할 때는 식품 알레르기의 유병률과 알레르겐을 포함한 대처방안이 필요하다고 본다.

Keywords

References

  1. Yang MS, Lee SH, Kim KM., Kwon HS, Kim DI, Park CH, Shon SU, Park HS, Jang YS, Kim SS, Jo SH, Min KU, Kim UY. A case report of food-dependent exercise-induced anaphylaxis to apple. Korean J Asthma Allergy Clin Immunol 2006;26(3):242-245
  2. The Korean Academy of Asthma Allergy Clinical Immunology. Asthma and Allergic Diseases. Yeomungag Press 2012, pp.445-469
  3. Kettelhut BV, Metcafe DD, Adverse reaction to food allergy principle and practice. 3rd ed., Mosby Co, 1988, pp.1482-1489
  4. Arbeiter HL. How prevalent in allergy among United States school children? Clin. Pediatrics 1967;6,140-145 https://doi.org/10.1177/000992286700600307
  5. Sampson HA. Update on food allergy. Journal of Allergy and Clinical Immunology 2004;113(5): 805-819 https://doi.org/10.1016/j.jaci.2004.03.014
  6. Sicherer SH, Sampson HA. Food allergy. Journal of Allergy and Clinical Immunology 2010;125(2):116-125 https://doi.org/10.1016/j.jaci.2009.09.051
  7. Chafen JS, Newberry SJ, Riedl MA, Bravata DM, Maglione M, Suttorp MJ. Diagnosing and managing common food allergies: a systematic review. JAMA 2010;303,1848-1856 https://doi.org/10.1001/jama.2010.582
  8. Oh JW, Pyun BY, Choung JT, Ahn KM, Song SW, Son JA, Lee SY, Lee SI. Epidemiological change of atopic dermatitis and food allergy in school-aged children in Korea between 1995 and 2000. J Korean Med Sci 2004;19(5): 716-723 https://doi.org/10.3346/jkms.2004.19.5.716
  9. Kim JH, Chang EY, Han YS, Ahn KM, Lee SI. The incidence and risk factors of immediate type food allergy during the first year of life in Korean infants: a birth cohort study. Pediatr Allergy Immunol 2011;22(7): 715-719 https://doi.org/10.1111/j.1399-3038.2011.01163.x
  10. Kim SH, Kang HR, Kim KM, Kim TB, Kim SS, Chang YS, Kim CW, Bahn JW, Kim YK, Choi SH, Park HS, Kim NS. The sensitization rates of food allergens in a Korean population: a multi-center study. Journal of Allergy and Clinical Immunology 2003;23(3):502-512
  11. Jung YH, Ko H, Kim HY, Seo JH, Kwon JW, Kim BJ, Kim HB, Lee SY, Jang GC, Song DJ, Kim WK, Shim JY, Hong SJ. Prevalence and risk factors of food allergy in preschool children in Seoul, Journal of Allergy and Clinical Immunology 2011;31(3): 177-182.
  12. Oehlschlager S, Reece P, Brown A, Hughson E, Hird H, Chisholm J. Food allergy towards predictive testing for novel foods. Food Additives and Contaminants 2001;18(12): 1099-1107 https://doi.org/10.1080/02652030110050131
  13. Pereira B, Venter C, Grundy J, Clayton B, Arshad H, Dean T. Prevalence of sensitization to food allergens, reported adverse reaction to foods, food avoidance, and food hypersensitivity among teenagers. The Journal of Allergy and Clinical Immunology 2005;116(4): 884-892 https://doi.org/10.1016/j.jaci.2005.05.047
  14. Keet CA, Wood RA. Food allergy and anaphylaxis. Immunol Allergy Clin North Am 2007;27,193-212 https://doi.org/10.1016/j.iac.2007.03.005
  15. Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol 2007;120,683-646
  16. Katherine AV, Kathleen MK, Sera BF, Debra AS. Prevalence of self-reported food allergy in American adult and use of food labels. J Allergy Clin Immunol 2007;119(6): 1504-1510 https://doi.org/10.1016/j.jaci.2007.03.011
  17. Venter C, Pereira B, Voigt K, Grundy J, Clayton CB, Higgins B. Prevalence and cumulative incidence of food hypersensitivity in the first 3 years of life. Allergy 2008;63,354-359
  18. Zuidmeer L, Goldhahn K, Rona RJ, Gislason D, Summers C. The prevalence of plant food allergies: a systematic review. J Allergy Clin Immunol 2008;121,1210-1218 https://doi.org/10.1016/j.jaci.2008.02.019
  19. Hu Y, Chen J, Li H. Comparison of food allergy prevalence among Chinese infants in Chongqing, 2009 versus 1999. Pediatrics International 2010;52(5):820-824 https://doi.org/10.1111/j.1442-200X.2010.03166.x
  20. Osterballe M, Mortz CG, Hansen TK, Andersen KE, Bindslev-Jensen C. The prevalence of food hypersensitivity in young adults. Pediatr Allergy Immunol 2009;20:686-692 https://doi.org/10.1111/j.1399-3038.2008.00842.x
  21. Boyce JA, Assa′ad A, Burks AW, Jones SM, Sampson HA. Guidelines for the diagnosis and management of food allergy in the United States; report of the NIAID-sponsored Expert Panel. J Allergy Clin Immunol 2010;126(6): S1-S58 https://doi.org/10.1016/j.jaci.2010.10.007
  22. Andrew H, Jaramillo LR, Sicherer SH, Wood RA, Bock SA. National prevalence and risk factors for food allergy and relationship to asthma: Results from the National Health and Nutrition Examination Survey 2005-2006. Journal of Allergy and Clinical Immunology 2010;119(6):1504-1510
  23. Kim DS, Ban JS, Park EA, Lee JY, Lee JO, Chang EY, Kim JH, Han YS, Ahn KM, Lim IS. Survey of food allergy in elementary school students in Dongjak- gu using questionnaire. Journal of Allergy and Clinical Immunology 2011;31(4):254-258
  24. Chen J, Hu Y, Allen KJ, Ho MH, Li H. The prevalence of food allergy in infant in Chongqing, China. Pediatric Allergy Immunol 2011;22(4):356-360 https://doi.org/10.1111/j.1399-3038.2011.01139.x
  25. Sicherer SH. Epidemiology of food allergy. J Allergy Clin Immunol 2011;127(3): 594-602 https://doi.org/10.1016/j.jaci.2010.11.044
  26. Han YS, Kim JH, Ahn KM. Food allergy. Korean J Pediatr 2012;55(5):153-158 https://doi.org/10.3345/kjp.2012.55.5.153
  27. Lianne S, Moshe B, Daniel WH, Joseph F, Lawrence J, Yvan P, Samuel BG, Sebastien V, Susan JE, Ann EC. Overall prevalence of self-reported food allergy in Canada. The Journal of Allergy and Clinical Immunology 2012;130(4):986-988 https://doi.org/10.1016/j.jaci.2012.06.029
  28. Lee KH. An epidemiologic study on food allergy. Unpublished doctoral dissertation. Kyungpook National University, 1997(Korean)
  29. Ben Shoshan M, Harrington DW, Sollar L, Fragapane J, Joseph L, Pierre Y. A population-based study on peanut, tree, nut, fish, shellfish, and sesame allergy prevalence in Canada. J Allergy Clin Immunol 2010;125,1322-1326 https://doi.org/10.1016/j.jaci.2010.03.029
  30. Shek LP, Cabrera-Morales EA, Soh SE, Gerez I. A population- based questionnaire survey on the prevalence of peanut, tree, nut, and shellfish allergy in 2 Asian populations. J Allergy Clin Immunol 2010;126,324-331 https://doi.org/10.1016/j.jaci.2010.06.003
  31. Ahn KM. Food allergy: Diagnosis and Management. Journal of Allergy and Clinical Immunology 2011;31(3):163-167
  32. Shin TS, Lee GJ, Yoon HS. A survey of the distribution of allergic disease in primary schoolchildren. Journal of Allergy and Clinical Immunology 1990;10(3):201-212

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