Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Physicochemical Characteristics of Fe3O4 Magnetic Nanocomposites Based on Poly(N-isopropylacrylamide) for Anti-cancer Drug Delivery

  • Davaran, Soodabeh (Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences) ;
  • Alimirzalu, Samira (Lab of Polymer, Faculty of Chemistry, Payamenoor University) ;
  • Nejati-Koshki, Kazem (Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences) ;
  • Nasrabadi, Hamid Tayefi (Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences) ;
  • Akbarzadeh, Abolfazl (Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences) ;
  • Khandaghi, Amir Ahmad (Faculty of Medicine, Tabriz University of Medical Sciences) ;
  • Abbasian, Mojtaba (Lab of Polymer, Faculty of Chemistry, Payamenoor University) ;
  • Alimohammadi, Somayeh (Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences)
  • Published : 2014.01.15
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Abstract

Background: Hydrogels are a class of polymers that can absorb water or biological fluids and swell to several times their dry volume, dependent on changes in the external environment. In recent years, hydrogels and hydrogel nanocomposites have found a variety of biomedical applications, including drug delivery and cancer treatment. The incorporation of nanoparticulates into a hydrogel matrix can result in unique material characteristics such as enhanced mechanical properties, swelling response, and capability of remote controlled actuation. Materials and Methods: In this work, synthesis of hydrogel nanocomposites containing magnetic nanoparticles are studied. At first, magnetic nanoparticles ($Fe_3O_4$) with an average size 10 nm were prepared. At second approach, thermo and pH-sensitive poly (N-isopropylacrylamide -co-methacrylic acid-co-vinyl pyrrolidone) (NIPAAm-MAA-VP) were prepared. Swelling behavior of co-polymer was studied in buffer solutions with different pH values (pH=5.8, pH=7.4) at $37^{\circ}C$. Magnetic iron oxide nanoparticles ($Fe_3O_4$) and doxorubicin were incorporated into copolymer and drug loading was studied. The release of drug, carried out at different pH and temperatures. Finally, chemical composition, magnetic properties and morphology of doxorubicin-loaded magnetic hydrogel nanocomposites were analyzed by FT- IR, vibrating sample magnetometry (VSM), scanning electron microscopy (SEM). Results: The results indicated that drug loading efficiency was increased by increasing the drug ratio to polymer. Doxorubicin was released more at $40^{\circ}C$ and in acidic pH compared to that $37^{\circ}C$ and basic pH. Conclusions: This study suggested that the poly (NIPAAm-MAA-VP) magnetic hydrogel nanocomposite could be an effective carrier for targeting drug delivery systems of anti-cancer drugs due to its temperature sensitive properties.

Keywords

References

  1. Akbarzadeh A, Nejati-Koshki K, Mahmoudi Soghrati M, et al (2013). In vitro studies of NIPAAM-MAA-VP copolymercoated magnetic nanoparticles for controlled anticancer drug release. JEAS, 3, 108-15. https://doi.org/10.4236/jeas.2013.34013
  2. Akbarzadeh A, Rezaei A, Nejati-Koshki K, et al (2014). Synthesis and Physicochemical Characterization of Biodegradable star-shaped poly lactide-co-glycolide-${\beta}$ -cyclodextrin copolymer Nanoparticles Containing Albumin, J Adv Nanoparticles, 3, 1-9. https://doi.org/10.4236/anp.2014.31001
  3. Akbarzadeh A, Samiei M, Joo SW, et al (2012). Synthesis, characterization and in vitro studies of doxorubicin-loaded magnetic nanoparticles grafted to smart copolymers on A549 lung cancer cell line. J Nanobiotechnology, 10, 46-52 https://doi.org/10.1186/1477-3155-10-46
  4. Akbarzadeh A, Zarghami N, Mikaeili H, et al (2012). Synthesis, characterization and in vitro evaluation of novel polymercoated magnetic nanoparticles for controlled delivery of doxorubicin. Nanotechnol Sci Appl, 5, 13-25.
  5. Akbarzadeh A, Mikaeili H, Zarghami N, et al (2012). Preparation and in-vitro evaluation of doxorubicin-loaded $Fe_3O_4$ magnetic nanoparticles modified with biocompatible copolymer. Int J Nanomedicine, 7, 1-16. https://doi.org/10.2217/nnm.11.171
  6. Akbarzadeh A, Samiei M, Davaran S, et al (2012). Magnetic nanoparticles: preparation, physical properties, and applications in biomedicine. Nanoscale Res Lett, 7, 14-26 https://doi.org/10.1186/1556-276X-7-14
  7. Budhlall BM, Marquez M, Velev OD (2008). Microwave, photo-and thermally responsive PNIPAAm gold nanoparticle microgels. Langmuir, 24, 11959-66. https://doi.org/10.1021/la8019556
  8. Chen J, Yang L, Liu Y, et al (2005). Preparation and characterization of magnetic targeted drug controlled-release hydrogel microspheres. Macromol Symp, 1, 71-80.
  9. Dresco PA, Zaitsev VS, Gambino RJ, Chu B (1999). Preparation and properties of magnetite and polymer magnetite nanoparticles. Langmuir, 15, 1945-51. https://doi.org/10.1021/la980971g
  10. Frimpong RA, Hilt JZ, Peppas NA, Thomas JB (2007). Nanotechnology in therapeutics: Current technology and applications. Horizon Scientific Press, 21, 241-56.
  11. Frimpong RA, Fraser S, Hilt J Z (2007). Synthesis and temperature response analysis of magnetic-hydrogel nanocomposites. J Biomed Mater Res A, 80, 1-6.
  12. Ghasemali S, Akbarzadeh A, Rahmati Yamchi M, et al (2013). Inhibitory Effects of ${\beta}$-Cyclodextrin-Helenalin Complexes on H-TERT Gene Expression in the T47D Breast Cancer Cell Line-Results of Real Time Quantitative PCR. Asian Pac J Cancer Prev, 14, 6949-53 https://doi.org/10.7314/APJCP.2013.14.11.6949
  13. Gattas-Asfura KM, Zheng Y, Micic M, et al (2003). Immobilization of quantum dots in the photo-cross-linked poly(ethylene glycol)-based hydrogel. J Phys Chem, 38, 10464-69.
  14. Hoare TR, Kohane DS (2008). Hydrogels in drug delivery: Progress and challenges. Polymer, 49, 1993-2007. https://doi.org/10.1016/j.polymer.2008.01.027
  15. Kost J, Langer R (2001). Responsive polymeric delivery systems. Adv Drug Deliver, 46, 125-48. https://doi.org/10.1016/S0169-409X(00)00136-8
  16. Lin CC, Metters AT (2006). Hydrogels in controlled release formulations: Network design and mathematical modeling. Adv Drug Deliver, 58, 1379-408. https://doi.org/10.1016/j.addr.2006.09.004
  17. Mollazade M, Nejati-Koshki K, Akbarzadeh A, et al (2013). PAMAM Dendrimers Arugment Inhibitory Effect of Curcumin on Cancer Cell Proliferation: Possible Inhibition of Telomerase. Asian Pac J Cancer Prev, 14, 6925-9 https://doi.org/10.7314/APJCP.2013.14.11.6925
  18. Miyako E, Nagata H, Hirano K, Hirotsu T (2008). Photodynamic thermoresponsive nanocarbon-polymer gel hybrids. Langmuir, 10, 1711-15.
  19. Muller-Schulte D, Schmitz-Rode T (2006). Thermosensitive magnetic polymer particles as contactless controllable drug carriers. J Magn Magn Mater, 302, 267-71. https://doi.org/10.1016/j.jmmm.2005.05.043
  20. Nejati-Koshki K, Zarghami N, Pourhassan-Moghaddam M, et al (2012). Inhibition of leptin gene expression and secretion by silibinin: possible role of estrogen receptors. Cytotechnology, 64, 719-26. https://doi.org/10.1007/s10616-012-9452-3
  21. Nejati-Koshki K, Akbarzadeh A, Pourhasan-Moghadam M, et al (2013). Inhibition of Leptin and Leptin Receptor Gene Expression by Silibinin-Curcumin Combination. Asian Pac J Cancer Prev, 14, 6595-9 https://doi.org/10.7314/APJCP.2013.14.11.6595
  22. Peppas NA, Bures P, Leobandung W, Ichikawa H (2000). Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm, 50, 27-46. https://doi.org/10.1016/S0939-6411(00)00090-4
  23. Qiu Y, Park K (2001). Environment-sensitive hydrogels for drug delivery. Adv Drug Deliver, 53, 321-39. https://doi.org/10.1016/S0169-409X(01)00203-4
  24. Satarkar NS, Hilt JZ (2008). Nanocomposite hydrogels as remote controlled biomaterials, Acta Biomater, 4, 11-16. https://doi.org/10.1016/j.actbio.2007.07.009
  25. Shiotani A, Mori T, Niidome T, et al (2007). Stab incorporation of gold nanorods into N-Isopropylacrylamide hydrogels and the rapid shrinkage induced by near-infrared laser irradiation. Langmuir, 23, 4012-18. https://doi.org/10.1021/la0627967
  26. Thomas V, Namdeo M, Mohan YM, et al (2008). Review on polymer, hydrogel and microgel metal nanocomposites. A facile nanotechnological approach. J Macromol, 45, 107-19.
  27. Valizadeh A, Mikaeili H, Samiei M, et al (2012). Quantum dots: synthesis, bioapplications and toxicityNanoscale. Res Lett, 7, 480.
  28. Wang X, Gu H, Yang Z (2005). The heating effect of magnetic fluids in an alternating magnetic field. J Magn Magn Mater, 293, 334-40. https://doi.org/10.1016/j.jmmm.2005.02.028
  29. Xu H, Wang YJ, Zheng YD, et al (2007). Preparation and characterization of bioglass/polyvinyl alcohol composite hydrogel. Biomed Mater, 2, 62-6. https://doi.org/10.1088/1748-6041/2/2/002
  30. Xu ZZ, Wang CC, Yang WL, Deng YH (2004). Encapsulation of nanosized magnetic iron oxide by polyacrylamide via inverse miniemulsion polymerization. J Magn Magn Mater, 277, 136-43. https://doi.org/10.1016/j.jmmm.2003.10.018

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