Asian Pacific Journal of Cancer Prevention

  • 제15권6호
  • /
  • Pages.2847-2850
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Parental Age-Related Risk of Retinoblastoma in Iranian Children

  • Saremi, Leila (Department of Biology, Science and Research Branch, Islamic Azad University) ;
  • Imani, Saber (Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences) ;
  • Rostaminia, Maryam (Faculty of Mathematics and Computer, University of Sheikh Bahaei) ;
  • Nadeali, Zakiye (Department of Biology, Faculty of Science, University of Isfahan)
  • 발행 : 2014.03.30
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초록

Background: Retinoblastoma is a rare malignant intraocular neoplasm. About 90% of cases feature a germline mutation in the RB1 gene and these will develop retinoblastoma during their early childhood. An association between mutations in germline cells and aging has been demonstrated. This suggests a higher incidence of childhood cancer including retinoblastoma among children of older parents. Materials and Methods: In the present study we aimed to determine the association of paternal and maternal age with an increased risk of retinoblastoma in a case-control study in Iranian population. The study was carried out on 240 persons who were born during 1984-2012 in Mahak and Mofid hospitals in Tehran, Iran. The statistical analysis included studying the mean age of parents and in order to know whether parental age of patients is different from parental age of control group, (t-test) compare averages test is used perfectly. By binary logistic regression, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: The results of statistical analysis including the study of mean parental age by the use of (t-test) compare averages test showed a significant difference between parental ages of patients and controls. Logistic regression showed that coefficients were significant for maternal but not paternal age. Conclusions: Our findings indicate that advanced maternal age can increase the risk of retinoblastoma in offspring, but the paternal age has no significant effect.

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참고문헌

  1. Abramson DH, Schefler AC (2010). Update on retinoblastoma. Retina, 24, 828-48.
  2. Broaddus E, Topham A, Singh AD (2009). Incidence of retinoblastoma in the USA: 1975-2004. Br J Ophthalmol, 93, 21-3. https://doi.org/10.1136/bjo.2008.138750
  3. Crow JF (2000). The origins, patterns and implications of human spontaneous mutation. Nat Rev Genet, 1, 40-7.
  4. Daniel MA (2013). Historic review of retinoblastoma. Ophthalmology, 94, 654-62.
  5. Dimaras H, Kimani K, Dimba EA (2012). Retinoblastoma. Lancet, 379, 1436-46. https://doi.org/10.1016/S0140-6736(11)61137-9
  6. Dockerty JD, Draper G, Vincent T, et al (2001). Case-control study of parental age, parity and socioeconomic level in relation to childhood cancers. Int J Epidemiol, 30, 1428-37. https://doi.org/10.1093/ije/30.6.1428
  7. Esteller M (2008). Epigenetics in cancer. N Engl J Med, 358, 1148-59. https://doi.org/10.1056/NEJMra072067
  8. Friend SH, Bernards R, Rogelj S, et al (1986). Identification of a human DNA segment having properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature, 323, 643-6. https://doi.org/10.1038/323643a0
  9. Hitchins MP, Ap Lin V, Buckle A, et al (2007). Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer. Cancer Res, 67, 9107-16. https://doi.org/10.1158/0008-5472.CAN-07-0869
  10. Howlader N, Noone AM, Krapcho M, et al (2013). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda.
  11. Johnson KJ, Carozza SE, Chow EJ, et al (2009). Parental age and risk of childhood cancer: a pooled analysis. Epidemiology, 20, 475. https://doi.org/10.1097/EDE.0b013e3181a5a332
  12. Lightfoot T, Bunch K, Ansell P, Murphy M (2005). Ovulation induction, assisted conception and childhood cancer. Eur J Cancer, 41, 715-24. https://doi.org/10.1016/j.ejca.2004.07.032
  13. Katy B (2013). Retinoblastoma: the parental perspective, BUJO, 11, 1-5.
  14. Johnson KJ, Carozza S, et al (2010). Parental age and risk of childhood cancer: a pooled analysis. Epidemiology, 20, 475-83.
  15. Khetan V, Gupta A, Gopal L (2011). Retinoblastoma: recent trends a mini review based on published literature. Oman J Ophthalmol, 4,108. https://doi.org/10.4103/0974-620X.91265
  16. MacCarthy A, Bayne A, Draper G, et al (2009). Non-ocular tumours following retinoblastoma in Great Britain 1951 to 2004. Br J Ophthalmol, 93, 1159-62. https://doi.org/10.1136/bjo.2008.146035
  17. MacCarthy A, Bunch K, Fear N, et al (2009). Paternal occupation and retinoblastoma: a case-control study based on data for Great Britain 1962-1999. Occup Environ Med, 66, 644-9. https://doi.org/10.1136/oem.2007.037218
  18. Marees T, Moll AC, Imhof SM, et al (2008). Risk of second malignancies in survivors of retinoblastoma: more than 40 years of follow-up. J Natl Cancer Inst, 100, 1771-9. https://doi.org/10.1093/jnci/djn394
  19. Mehta M, Sethi S, Pushker N, et al (2012). Singapore Med J, 53, 128-35.
  20. Mills MB, Hudgins L, Balise RR, et al (2013). Mutation risk associated with paternal and maternal age in a cohort of retinoblastoma survivors. Hum Genet, 131, 1126-40.
  21. Neelanjana M, Sabaratnam A (2008). Malignant conditions in children born after assisted reproductive technology. Obstet Gynecol Surv. 63, 669-76. https://doi.org/10.1097/OGX.0b013e318181a9f0
  22. Shah I, Baig A, Razzaq A, et al (2013). Trilateral retinoblastoma with unilateral eye involvement. J Pak Med Assoc, 63, 910-12.
  23. Yip BH, Pawitan Y, Czene K (2006). Parental age and risk of childhood cancers: a population-based cohort study from Sweden. Int J Epidemiol, 35, 1495-503. https://doi.org/10.1093/ije/dyl177
  24. Yu CL, Tucker MA, Abramson DH, et al (2009). Cause-specific mortality in long-term survivors of retinoblastoma. J Natl Cancer Inst, 101, 581-91. https://doi.org/10.1093/jnci/djp046
  25. Yongsheng Liu, Mingxing Zhi, Xiuju Li (2011). Parental age and characteristics of the offspring, Ageing Res Rev, 10, 115-23. https://doi.org/10.1016/j.arr.2010.09.004
  26. Zand AM, Imani S, Saadati M, et al (2012). Statistical Approach through Discovery of Impacting Factors on Emergence of Blood Cancers. Asian Pac J Cancer Prev, 13, 78-83.

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