Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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The Research Progress of the Interactions between miRNA and Wnt/beta-catenin Signaling Pathway in Breast Cancer of Human and Mice

  • Ye, Ni (Animal Biotechnology Center, Sichuan Agricultural University) ;
  • Wang, Bin (Animal Biotechnology Center, Sichuan Agricultural University) ;
  • Quan, Zi-Fang (Animal Biotechnology Center, Sichuan Agricultural University) ;
  • Pan, Hai-Bo (Animal Biotechnology Center, Sichuan Agricultural University) ;
  • Zhang, Man-Li (Animal Biotechnology Center, Sichuan Agricultural University) ;
  • Yan, Qi-Gui (Animal Biotechnology Center, Sichuan Agricultural University)
  • Published : 2014.02.01
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Abstract

MicroRNA expression is a research focus in studies of tumors. This article concentrates attention on potential links between tumors caused by mouse mammary tumor virus (MMTV) and human breast cancer, in order to provide theoretical basis for using mouse model to search for miRNA effects mediated by Wnt/beta-catenin signaling in human breast cancer. By analyzing interactions between miRNAs and the Wnt/beta-catenin signaling pathway in breast cancer, we hope to casts light on more biological functions of miRNAs in the process of tumor formation and growth and to explore their potential value in cancer diagnosis, prognosis and treatment. Our endeavor aimed at providing theoretical basis for finding safer, more effective methods for treatment of human breast cancer at the miRNA molecular level.

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