Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Methylenetetrahydrofolate Reductase Polymorphisms and Susceptibility to Esophageal Cancer in Chinese Populations: a Meta-analysis

  • Published : 2014.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

Although many epidemiologic studies investigated the methylenetetrahydrofolate reductase (MTHFR) polymorphisms and their associations with esophageal cancer, definite conclusions could not be drawn. To clarify the effects of MTHFR polymorphisms on the risk of esophageal cancer, a meta-analysis was here performed in Chinese populations. A total of 16 studies including 3,040 cases and 4,127 controls were involved in this metaanalysis. Overall, significant associations were found between the MTHFR C677T polymorphism and esophageal cancer risk when all studies in Chinese populations were pooled into the meta-analysis (T vs. C, OR = 1.19, 95% CI = 1.06-1.34; TT vs. CC, OR = 1.35, 95% CI = 1.07-1.70; TT+ CT vs. CC, OR = 1.29, 95% CI = 1.08-1.54; TT vs. CC + CT, OR = 1.19, 95% CI = 1.03-1.37). In subgroup analyses stratified by ethnicity and source of controls, the same results were found in Kazakh (TT vs. CC, OR = 1.38, 95% CI = 1.02-1.87; TT + CT vs. CC, OR = 1.50, 95% CI = 1.03-2.18), in not stated populations (T vs. C, OR = 1.24, 95% CI = 1.08-1.42; TT vs. CC, OR = 1.47, 95% CI = 1.10-1.96; TT + CT vs. CC, OR = 1.30, 95% CI = 1.05-1.60; TT vs. CC + CT, OR = 1.32, 95% CI = 1.12-1.56), and in hospital-based studies (T vs. C, OR = 1.34, 95% CI = 1.19-1.51; TT vs. CC, OR = 1.81, 95% CI = 1.37-2.39; TT + CT vs. CC, OR = 1.51, 95% CI = 1.26-1.83; and TT vs. CC + CT, OR = 1.39, 95% CI = 1.13-1.70). In conclusion, this meta-analysis provides evidence that the MTHFR C677T polymorphism contributes to esophageal cancer development in Chinese populations.

Keywords

References

  1. Cai JF, Qin JM, Liao PH, et al (2011). Value of detection of HLA, other immune-related genes and MTHFR in the screening of esophageal cancer in Xinjiang Kazakh population. World Chin J Digestol, 19, 2572-6 (in Chinese).
  2. Chang-Claude JC, Wahrendorf J, Liang QS, et al (1990). An epidemiological study of precursor lesions of esophageal cancer among young persons in a high risk population in Huixian, China. Cancer Res, 50, 2268-74.
  3. Chen Y, Yin D, Deng YC, et al (2009). Relationship between MTHFR gene polymorphisms and susceptibility of esophageal cancer of Han nationality in Xinjiang. J Toxicol (in Chinese), 23, 429-32.
  4. Fang Y, Xiao F, An Z, et al (2011). Systematic review on the relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and esophageal squamous cell carcinoma. Asian Pac J Cancer Prev, 12, 1861-6.
  5. Friedman G, Goldschmidt N, Friedlander Y, et al (1999). A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations. J Nutr, 129, 1656-61.
  6. Frosst P, Blom HJ, Milos R, et al (1995). A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet, 10, 111-3. https://doi.org/10.1038/ng0595-111
  7. Gao CM, Toshiro T, Wu JZ, et al (2004). A case-control study on the polymorphisms of methylenetetrahydrofolate reductase 1298A-->C and susceptibility of esophageal cancer. Zhonghua Liu Xing Bing Xue Za Zhi, 25, 341-5 (in Chinese).
  8. Hu J, Nyren O, Wolk A, et al (1994). Risk factors for oesophageal cancer in northeast China. Int J Cancer, 57, 38-46.
  9. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  10. Kim YI (2000). Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis. Nutr Rev, 58, 205-9.
  11. Langevin SM, Lin D, Matsuo K, et al (2009). Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer. Toxicol Lett, 184, 73-80. https://doi.org/10.1016/j.toxlet.2008.09.003
  12. Li QD, Li H, Wang MS, et al (2011). Multi-susceptibility genes associated with the risk of the development stages of esophageal squamous cell cancer in Feicheng County. BMC Gastroenterol, 11, 74. https://doi.org/10.1186/1471-230X-11-74
  13. Lin Y, Totsuka Y, He Y, et al (2013). Epidemiology of esophageal cancer in Japan and China. J Epidemiol, 23, 233-42. https://doi.org/10.2188/jea.JE20120162
  14. Liu YX, Wang B, Wan MH, et al (2011). Meta-analysis of the relationship between the metholenetetrahydrofolate reductase C677T genetic polymorphism, folate intake and esophageal cancer. Asian Pac J Cancer Prev, 12, 247-52.
  15. Qin JM, Yang L, Chen B, et al (2008). Interaction of methylenetetrahydrofolate reductase C677T, cytochrome P4502E1 polymorphism and environment factors in esophageal cancer in Kazakh population. World J Gastroenterol, 14, 6986-92. https://doi.org/10.3748/wjg.14.6986
  16. Qu HH, Cui LH, Wang K, et al (2013). The methylenetetrahydrofolate reductase C677T polymorphism influences risk of esophageal cancer in Chinese. Asian Pac J Cancer Prev, 14, 3163-8. https://doi.org/10.7314/APJCP.2013.14.5.3163
  17. Song C, Xing D, Tan W, et al (2001). Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population. Cancer Res, 61, 3272-5.
  18. Stolzenberg-Solomon RZ, Qiao YL, Abnet CC, et al (2003). Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, China. Cancer Epidemiol Biomarkers Prev, 12, 1222-6.
  19. Tan X, Wang YY, Dai L, et al (2013). Genetic polymorphism of MTHFR A1298C and esophageal cancer susceptibility: a meta-analysis. Asian Pac J Cancer Prev, 14, 1951-5. https://doi.org/10.7314/APJCP.2013.14.3.1951
  20. Wang LD, Guo RF, Fan ZM, et al (2005). Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population. Dis Esophagus, 18, 177-84. https://doi.org/10.1111/j.1442-2050.2005.00492.x
  21. Wang Q, Li D, Ye WJ, et al (2009). Effect of MTHFR C677T mutation, interaction between MTHFR C677T mutation and environm ental factors on esophageal cancer. Chin J Public Health, 25, 1308-10 (in Chinese).
  22. Wang Y, Guo W, He Y, et al (2007). Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China. Cancer Causes Control, 18, 143-52. https://doi.org/10.1007/s10552-006-0097-4
  23. Weisberg I, Tran P, Christensen B, et al (1998). A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab, 64, 169-72. https://doi.org/10.1006/mgme.1998.2714
  24. Wen YY, Yang SJ, Zhang JX, et al (2013). Methylenetetrahydrofolate reductase genetic polymorphisms and esophageal squamous cell carcinoma susceptibility: a meta-analysis of case-control studies. Asian Pac J Cancer Prev, 14, 21-5. https://doi.org/10.7314/APJCP.2013.14.1.21
  25. Wu JZ, Gao CM, Ding JH, et al (2002). Polymorphisms of methylenetetrahydrofolate reductase C677T and the risk of esophageal cancer. Tumor, 22, 268-70 (in Chinese).
  26. Yang JB, Shen YW, Zeng M, et al (2012). Relationship between MTHFR C677T polymorphisms and susceptibility of esophageal cancer in north Sichuan population. Sichuan Med, 33, 26-7 (in Chinese).
  27. Zacho J, Yazdanyar S, Bojesen SE, et al (2011). Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75, 000 cases and 93, 000 controls. Int J Cancer, 128, 644-52. https://doi.org/10.1002/ijc.25375
  28. Zhang JF, Pang LJ, Zhao J, et al (2006). Association of methylenetetrahydrofolate reductase C677T polymorphism with susceptibility to esophageal caner in Kazakh and Han populations in Xinjiang Uygur Autonomous Region. World Chin J Digestol, 14, 1475-80 (in Chinese).
  29. Zhang LW, Ilyar Sheyhidin, Wu MB, et al (2008). Study on relationship between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of Kazakh's esophageal cancer in Xinjiang. Chin J Cancer Prev Treat, 15, 1294-7 (in Chinese).
  30. Zhang ZF, Kurtz RC, Yu GP, et al (1997). Adenocarcinomas of the esophagus and gastric cardia: the role of diet. Nutr Cancer, 27, 298-309. https://doi.org/10.1080/01635589709514541
  31. Zhao P, Lin F, Li Z, et al (2011). Folate intake, methylenetetrahydrofolate reductase polymorphisms, and risk of esophageal cancer. Asian Pac J Cancer Prev, 12, 2019-23.

Cited by

  1. Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis vol.15, pp.15, 2014, https://doi.org/10.7314/APJCP.2014.15.15.6211
  2. Association between MTHFR C677T Polymorphism and Risk of Prostate Cancer: Evidence from 22 Studies with 10,832 Cases and 11,993 Controls vol.16, pp.11, 2015, https://doi.org/10.7314/APJCP.2015.16.11.4525
  3. Relationship between Genetic Polymorphisms in MTHFR (C677T, A1298C and their Haplotypes) and the Incidence Of Breast Cancer among Jordanian Females - Case-Control Study vol.16, pp.12, 2015, https://doi.org/10.7314/APJCP.2015.16.12.5007
  4. gene polymorphisms and their associations with diseases among Chinese population vol.92, pp.3, 2017, https://doi.org/10.1111/cge.12929
  5. Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta-analysis and genome-wide association studies pp.20457634, 2019, https://doi.org/10.1002/cam4.1972