Asian Pacific Journal of Cancer Prevention

  • 제15권5호
  • /
  • Pages.2061-2067
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Relationship Between Prognosis and Neutrophil: Lymphocyte and Platelet:Lymphocyte Ratios in Patients with Malignant Pleural Mesotheliomas

  • Cihan, Yasemin Benderli (Department of Radiation Oncology, Kayseri Education and Research Hospital) ;
  • Ozturk, Ahmet (Department of Biostatistics, Erciyes University Faculty of Medicine) ;
  • Mutlu, Hasan (Department of Medical Oncology, Kayseri Acibadem Hospital)
  • 발행 : 2014.03.01
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초록

Background: It has been demonstrated that neutrophil:lymphocyte (NLR) and platelet:lymphocyte (PLR) ratios are associated with prognosis in cancer patients. The aim of this study was to investigate whether pretreatment white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet, basophil and eosinophil counts, LDH level, NLR and PLR are associated with prognosis in patients with malignant pleural mesothelioma (MPM). Materials and Methods: We retrospectively reviewed files of 50 patients who were managed with a diagnosis of MPM between 2005 and 2010. Demographic and clinical characteristics, treatments, response to treatment and prognostic factors were evaluated, along with relationships between pretreatment blood parameters and prognosis. Results: Overall, 38 men and 12 women were included to the study. Mean age was $61.5{\pm}9.4$ years (range: 39-83 years). There was advanced disease in 86% (n=43) and the histological type was epithelial mesothelioma in the majority (82%). Of the cases, 17 (34%) received radiotherapy, while 42 cases underwent first- and second-line chemotherapy, with cisplatin plus pemetrexed as the most commonly used regimen. In the assessment after therapy, it was found that there was complete response in 4 cases (8%), partial response in 10 cases (20%), stable disease in 17 cases (34%) and progression in 19 cases (38%). Median follow-up was 10 months (range: 10 day-30 months). Median overall survival was found to be 20.7 months while median progression-free survival as 10 months. In univariate and multivariate analyses, it was found that factors significantly affecting overall survival included stage (p=0.030), response to treatment (p=0.026) and monocyte count (p=0.004), while factors affecting disease-free survival included NLR (p=0.018), response to treatment (p=0.001), and PLR score (p=0.003). Conclusions: Overall and disease-free survival was found to be better in cases with a WBC count<8.000, platelet count<300,000, and low NLR and PLR scores in malignant pleural mesothelioma.

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참고문헌

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  1. Treatment of Metastatic Colorectal Cancer With or Without Bevacizumab: Can the Neutrophil/Lymphocyte Ratio Predict the Efficiency of Bevacizumab? vol.15, pp.12, 2014, https://doi.org/10.7314/APJCP.2014.15.12.4781
  2. Prognostic Significance of Systemic Inflammation-Based Lymphocyte- Monocyte Ratio in Patients with Lung Cancer: Based on a Large Cohort Study vol.9, pp.10, 2014, https://doi.org/10.1371/journal.pone.0108062
  3. Pretreatment thrombocytosis as a significant prognostic factor in malignant mesothelioma: a meta-analysis vol.28, pp.6, 2017, https://doi.org/10.1080/09537104.2016.1246712
  4. Clinical implications of pretreatment inflammatory biomarkers as independent prognostic indicators in prostate cancer pp.08878013, 2017, https://doi.org/10.1002/jcla.22277
  5. Prognostic Significance of Preoperative Circulating Monocyte Count in Patients With Breast Cancer vol.94, pp.49, 2015, https://doi.org/10.1097/MD.0000000000002266
  6. Analysis of prognostic factors of patients with malignant peritoneal mesothelioma vol.16, pp.1, 2018, https://doi.org/10.1186/s12957-018-1350-5
  7. Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma vol.2019, pp.1687-630X, 2019, https://doi.org/10.1155/2019/7103915