Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Hair-growth Promoting Effect of Microneedle Roller Therapy

미세침요법의 모발성장효과

  • Lee, Chang Hyun (Department of Anatomy, College of Korean Medicine, Woosuk University) ;
  • Lee, Ji Yeon (Division of Applied Medicine, School of Korean Medicine, Pusan National University) ;
  • Shin, Hyun Jong (Department of Pathology, College of Korean Medicine, Woosuk University) ;
  • Ha, Ki Tae (Division of Applied Medicine, School of Korean Medicine, Pusan National University) ;
  • Seo, Hyung Sik (Department of Ophthalmology, Otolaryngology and Dermatology, Korean Medicine Hospital of Pusan National University) ;
  • Jeong, Han Sol (Division of Applied Medicine, School of Korean Medicine, Pusan National University)
  • 이창현 (우석대학교 한의과대학 해부학교실) ;
  • 이지연 (부산대학교 한의학전문대학원 응용의학부) ;
  • 신현종 (우석대학교 한의과대학 병리학교실) ;
  • 하기태 (부산대학교 한의학전문대학원 응용의학부) ;
  • 서형식 (부산대학교 한방병원 안이비인후 피부과) ;
  • 정한솔 (부산대학교 한의학전문대학원 응용의학부)
  • Received : 2013.12.18
  • Accepted : 2014.01.07
  • Published : 2014.02.25
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Abstract

Micro needle roller therapy has been used for cosmetic purposes, such as reducing skin winkles and improving elasticity of skin. It is claimed that micro needle roller therapy has potentials for connective tissue regeneration by facilitating collagen synthesis. Therefore, there seems to be a possibility that connective tissue regenerating potential of micro needle roller therapy could influence the hair growth cycle. This study, we investigated the hair growth-promoting effects of micro needle roller therapy. C57BL/6 mice were devided into three groups as follows: normal saline-treated, minoxidil-treated, and micro needle roller therapy-received group. Hair growth activity was evaluated by handscopic and microscopic observations. Sections of dorsal skin were stained with hematoxylin and eosin. Expression of BrdU, FGF, and VEGF was detected by immunohistochemical staining. Micro needle roller therapy enhanced the development of hair follicle during anagen. Immunohistochemical analysis revealed that micro neeld roller therapy incresed the expression of BrdU and FGF in the hair follicles of C57BL/6 mice. Furthermore, micro needle roller therapy upregulated mRNA expression of VEGFR-2, FGF-2, EGF - growth factors that play a central role in hair follicle development during anagen. These results suggest that Micro needle roller therapy can potentially be used for the treatment of alopecia.

Keywords

References

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