Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Antidepressant-like Effects of Schisandra chinensis Baillon Water Extract on Animal Model Induced by Chronic Mild Stress

만성스트레스로 유발된 우울증 동물모델에서 오미자 물 추출물의 항우울 효과

  • Kang, Min Gu (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine) ;
  • Kim, Young Hwa (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine) ;
  • Im, A Rang (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine) ;
  • Nam, Byung Soo (Infrastructure Management Team, Korea Institute of Oriental Medicine) ;
  • Chae, Sung Wook (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine) ;
  • Lee, Mi Young (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine)
  • 강민구 (한국한의학연구원 한의신약개발그룹) ;
  • 김영화 (한국한의학연구원 한의신약개발그룹) ;
  • 임아랑 (한국한의학연구원 한의신약개발그룹) ;
  • 남병수 (한국한의학연구원 인프라운영팀) ;
  • 채성욱 (한국한의학연구원 한의신약개발그룹) ;
  • 이미영 (한국한의학연구원 한의신약개발그룹)
  • Received : 2014.04.03
  • Accepted : 2014.05.26
  • Published : 2014.06.30
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Abstract

Depression is one of the most common neuropsychiatric disorders and has been associated with the neuroendocrine system and alterations in behavior. Schisandra chinensis Baillon is one of major medicinal plants used as a Korea medicine and food sources, and has been processed in the fields of various food products and medicinal herbs. The chronic mild stress (CMS) protocol is widely used to evoke depressive-like behaviors in laboratory mice or rat. The CMS procedure induced some behavioral changes that are compatible with the common expectations, i.e. 'anhedonic' behavior and can affect corticosterone level. The present study, Schisandra chinensis extract administration by daily gavage from the 3 weeks exhibited an antidepressant-like effect on CMS-induced depression in mice. Schisandra chinensis extract administration at dose of 200mg/kg significantly increased the sucrose consumption, and decreased the immobility durations in forced swim test and tail suspension test. Furthermore the corticosterone level decreased than control group. In conclusion, Schisandra chinensis extract showed antidepressant-like effects on sucrose preference test, forced swimming test and tail suspension test based on CMS model.

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References

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