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Antidepressant-like Effects of Schisandra chinensis Baillon Water Extract on Animal Model Induced by Chronic Mild Stress

만성스트레스로 유발된 우울증 동물모델에서 오미자 물 추출물의 항우울 효과

  • Kang, Min Gu (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine) ;
  • Kim, Young Hwa (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine) ;
  • Im, A Rang (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine) ;
  • Nam, Byung Soo (Infrastructure Management Team, Korea Institute of Oriental Medicine) ;
  • Chae, Sung Wook (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine) ;
  • Lee, Mi Young (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine)
  • 강민구 (한국한의학연구원 한의신약개발그룹) ;
  • 김영화 (한국한의학연구원 한의신약개발그룹) ;
  • 임아랑 (한국한의학연구원 한의신약개발그룹) ;
  • 남병수 (한국한의학연구원 인프라운영팀) ;
  • 채성욱 (한국한의학연구원 한의신약개발그룹) ;
  • 이미영 (한국한의학연구원 한의신약개발그룹)
  • Received : 2014.04.03
  • Accepted : 2014.05.26
  • Published : 2014.06.30

Abstract

Depression is one of the most common neuropsychiatric disorders and has been associated with the neuroendocrine system and alterations in behavior. Schisandra chinensis Baillon is one of major medicinal plants used as a Korea medicine and food sources, and has been processed in the fields of various food products and medicinal herbs. The chronic mild stress (CMS) protocol is widely used to evoke depressive-like behaviors in laboratory mice or rat. The CMS procedure induced some behavioral changes that are compatible with the common expectations, i.e. 'anhedonic' behavior and can affect corticosterone level. The present study, Schisandra chinensis extract administration by daily gavage from the 3 weeks exhibited an antidepressant-like effect on CMS-induced depression in mice. Schisandra chinensis extract administration at dose of 200mg/kg significantly increased the sucrose consumption, and decreased the immobility durations in forced swim test and tail suspension test. Furthermore the corticosterone level decreased than control group. In conclusion, Schisandra chinensis extract showed antidepressant-like effects on sucrose preference test, forced swimming test and tail suspension test based on CMS model.

Keywords

References

  1. Anderson IM. (1998). SSRIs versus tricyclic antidepressants in depressed inpatients: a meta-analysis of efficacy and tolerability. Depression and Anxiety. 7:11-17. https://doi.org/10.1002/(SICI)1520-6394(1998)7:1+<11::AID-DA4>3.0.CO;2-I
  2. Baek NI, Han JT, Ahn EM, Park JK, Cho SW, Jeon SG, Jang JS, Kim CK and Choi SY. (2000). Isolation of anticonvulsant compounds from the fruits of Schizandra chinensis Baill. Journal of the Korean Society of Agricultural Chemistry and Biotechnology. 43:72-77.
  3. Bergstrom A, Jayatissa MN, Mork A and Wiborg O. (2008). Stress sensitivity and resilience in the chronic mild stress rat model of depression; an in situ hybridization study. Brain Research. 1196:41-52. https://doi.org/10.1016/j.brainres.2007.12.025
  4. Bouvier N, Trenque T and Millart H. (2003). Development of antidepressant drugs. Experience and prospects. Presse Medicale. 32:519-522.
  5. Chae HJ, Hwang HI, Lee IS and Moon HY. (2005) Comparison of on rat intestinal digestive enzyme inhibitory activity and antioxidant enzyme activity of Korean and Chinese Schizandra chinensis. Journal of Experimental & Biomedical Sciences. 11:517-523.
  6. Holsboer F and Barden N. (1996). Antidepressants and hypothalamicpituitary-adrenocortical regulation. Endocrine Reviews. 17:187-205. https://doi.org/10.1210/edrv-17-2-187
  7. Hwang SJ, Pyo BS, Lee HJ and Hwang B. (2004). Production of gomisin J from cell suspension cultures of Schisandra chinensis Baillon. Korean Journal of Medicinal Crop Science. 12:442-447.
  8. Ibarguen-Vargas Y, Surget A, Touma C, Palme R and Belzung C. (2008). Multifaceted strain-specic effects in a mouse model of depression and of antidepressant reversal. Psychoneuroendocrinology. 33:1357-1368. https://doi.org/10.1016/j.psyneuen.2008.07.010
  9. Kang M, Pyun KH, Jang CG, Kim H, Bae H and Shim I. (2005). Nelumbinis semen reverses a decrease in hippocampal 5-HT release induced by chronic mild stress in rats. Journal of Pharmacy and Pharmacology. 57:651-656. https://doi.org/10.1211/0022357056055
  10. Kendler KS, Karkowski LM and Prescott CA. (1999). Causal relationship between stressful life events and the onset of major depression. The American Journal of Psychiatry. 156:837-841. https://doi.org/10.1176/ajp.156.6.837
  11. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE and Wang PS. (2003). The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication(NCS-R). The Journal of the American Medical Association. 289:3095-3105. https://doi.org/10.1001/jama.289.23.3095
  12. Kennedy SH. (2006). A review of antidepressant treatments today. European Neuropsychopharmacology. 16:619-624. https://doi.org/10.1016/S0924-977X(06)70007-4
  13. Kim CH, Kwon MC, Kim SH, Bae GJ, Ahn JH, Chio GP, Chio YB, Ko JR and Lee HY. (2007). Enhancement of immune activites of Kadsura japonica Dunal. through conventional fermentation process. Korean Journal of Medicinal Crop Science. 15:162-169.
  14. Lee YM, Lee KS and Kim DK. (2009). Aqueous extract of Schizandra chinensis suppresses dextran sulfate sodium induced generation of IL-8 and ROS in the colonic epithelial cell line HT-29. Natural Product Sciences. 15:185-191.
  15. Linde K, Berner M, Egger M and Mulrow C. (2005). St. John' wort for depression: Meta-analysis of randomized, controlled trials. The British Journal of Psychiatry. 184:99-107.
  16. Luo DD, An SC and Zhang X. (2008). Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress. Brain Research Bulletin. 77:8-12. https://doi.org/10.1016/j.brainresbull.2008.05.010
  17. Mandrioli R, Mercolini L, Saracino MA and Raggi MA. (2012). Selective serotonin reuptake inhibitors(SSRIs): Therapeutic drug monitoring and pharmacological interactions. Current Medicinal Chemistry. 19:1846-1863. https://doi.org/10.2174/092986712800099749
  18. Mutlu O, Ulak G, Laugeray A and Belzung C. (2009). Effects of neuronal and inducible NOS inhibitor 1-[2-(trifluoromethyl) phenyl] imidazole(TRIM) in unpredictable chronic mild stress procedure in mice. Pharmacology Biochemistry and Behavior. 92:82-87. https://doi.org/10.1016/j.pbb.2008.10.013
  19. Nemeroff CB. (2007). The burden of severe depression: A review of diagnostic challenges and treatment alternatives. Journal of Psychiatric Research. 41:189-206. https://doi.org/10.1016/j.jpsychires.2006.05.008
  20. Papp M, Willner P and Muscat R. (1991). An animal model of anhedonia: Attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress. Psychopharmacology(Berlin). 104:255-259. https://doi.org/10.1007/BF02244188
  21. Park JH, Kim JH, Kim DH, Mun HC, Lee HJ, Seo SM, Paik KH, Ryu LH, Park JI and Lee HY. (2004). Comparison of immuno-stimulatory activities by purification process of Schizandra chinensis Baillon fruits. Korean Journal of Medicinal Crop Science. 12:141-148.
  22. Patten SB. (2008). Major depression prevalence is very high, but the syndrome is a poor proxy for community populations'0 clinical treatment needs. Canadian Journal of Psychiatry. 53:411-419. https://doi.org/10.1177/070674370805300702
  23. Panossian A and Wikman G. (2008). Pharmacology of Schisandra chinensis Bail: An overview of Russian research and uses in medicine. Journal of Ethnopharmacology. 118:183-212. https://doi.org/10.1016/j.jep.2008.04.020
  24. Porsolt RD, Le Pichon M and Jalfre M. (1977). Depression: A new animal model sensitive to antidepressant treatments. Nature. 266:730-732. https://doi.org/10.1038/266730a0
  25. Sadako Y, Yoshikazu M and Hironaka K. (1993). Preventive effect of gomisin A, a lignan component of Schizandra fruits, on acetaminophen-induced hepatotoxicty in rats. Biochemical Pharmacology. 46:1801-1085.
  26. Sarko J. (2000). Antidepressants, old and new. A review of their adverse effects and toxicity in overdose. Emergency Medicine Clinics of North America. 18:637-654. https://doi.org/10.1016/S0733-8627(05)70151-6
  27. Schulz V. (2006). Safety of St. John' Wort extract compared to synthetic antidepressants. Phytomedicine. 13:199-204. https://doi.org/10.1016/j.phymed.2005.07.005
  28. Steru L, Chermat R, Thierry B and Simon P. (1985). The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology. 85:367-370. https://doi.org/10.1007/BF00428203
  29. Steffens DC, Krishnan KR and Helms MJ. (1997). Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: A metaanalysis. Depression and Anxiety. 6:10-18. https://doi.org/10.1002/(SICI)1520-6394(1997)6:1<10::AID-DA2>3.0.CO;2-9
  30. Surget A, Wang Y, Leman S, Ibarguen-Vargas Y, Edgar N, Griebel G, Belzung C and Sibille E. (2009). Coricolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal. Neuropsychopharmacology. 34:1363-1380. https://doi.org/10.1038/npp.2008.76
  31. Tanti A and Belzung C. (2010). Open questions in current models of antidepressant action. British Journal of Pharmacology. 159:1187-1200. https://doi.org/10.1111/j.1476-5381.2009.00585.x
  32. Tsigos C and Chrousos GP. (1994). Physiology of the hypothalamicpituitary- adrenal axis in health and dysregulation in psychiatric and autoimmune disorders. Endocrinology and Metabolism Clinics of North America. 23:451-466.
  33. Vancassel S, Leman S, Hanonick L, Denis S, Roger J, Nollet M, Bodard S, Kousignian I, Belzung C and Chalon S. (2008). n-3 Polyunsaturated fatty acid supplementation reverses stress-induced modification on brain monoamine levels in mice. The Journal of Lipid Research. 49:340-348. https://doi.org/10.1194/jlr.M700328-JLR200
  34. Willner P. (1984). The validity of animal models of depression. Psychopharmacology. 83:1-16. https://doi.org/10.1007/BF00427414
  35. Willner P, Towell A, Sampson D, Sophokleous S and Muscat R. (1987). Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology. 93:358-364.
  36. Willner P, Muscat R and Papp M. (1992). Chronic mild stressinduced anhedonia: A realistic animal model of depression. Neuroscience & Biobehavioral Reviews. 16:525-534. https://doi.org/10.1016/S0149-7634(05)80194-0
  37. Willner P. (1997). Validity, reliability and utility of the chronic mild stress model of depression: A 10-year review and evaluation. Psychopharmacology. 134:319-329. https://doi.org/10.1007/s002130050456
  38. Willner P. (2005). Chronic mild stress (CMS) revisited: Consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology. 52:90-110. https://doi.org/10.1159/000087097

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