Food Science and Preservation (한국식품저장유통학회지)

The Korean Society of Food Preservation (한국식품저장유통학회)
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Inhibitory effect of dietary turmeric (Curcuma longa L.) ethanol extract on DMBA-induced mammary carcinogenesis in rats

울금 투여에 의한 DMBA 유발 랫드 유선암화과정 억제효과

  • Kim, Min Sook (Nature Pure Korea) ;
  • Jeong, Kyu Shik (Department of Pathology, College of Veterinary Medicine, Kyungpook National University) ;
  • You, Mi-Kyoung (Department of Food and Nutrition, Mokpo National University) ;
  • Kim, Hyeon-A (Department of Food and Nutrition, Mokpo National University)
  • Received : 2014.02.14
  • Accepted : 2014.04.22
  • Published : 2014.06.30
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Abstract

The purpose of this study was to examine the potential of turmeric (Curcuma longa L.) to inhibit 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in rats. Female Sprague Dawley rats were fed a control diet (NC and DC) or an ethanol extract of turmeric (DT) diet until the end of the experiment. The rats in the DC and DT groups were administered a single dose of DMBA (50 mg/Kg) by oral gavages at 50 days of age. The turmeric ethanol extracts decreased the incidence and multiplicity of DMBA-induced mammary tumor. The turmeric ethanol extract significantly decreased the tumor cell proliferation. The turmeric also significantly decreased the tumor grade based on the degree of the tubule formation. The results suggest that the ethanol extract of turmeric has an inhibitory effect against mammary carcinogenesis, and that such chemopreventive effect may be related to the inhibition of the initiation and the proliferation of tumor cells.

본 연구 결과 울금 에탄올 추출물이 DMBA에 의해 유도한 유선 암화과정에서 종양의 발생률과 종양수를 감소시킴을 확인하였다. 이러한 종양세포의 증식 억제 효과는 울금의 암 예방 효과에 대한 기본 메커니즘 중 하나이다. 앞으로 효과적인 투여 경로 및 조직 특이성을 검토하기 위하여 더 많은 연구가 필요하다고 사료된다.

Keywords

References

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