Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
권호 표지

Effects of Fermented Lotus Extracts on Glucose Intolerance and Lipid Metabolism-related Gene Expression

연잎-연근 복합 발효물이 흰쥐의 내당능 및 지질대사 관련 유전자 발현에 미치는 영향

  • Kim, Hyung-Gu (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dongguk University) ;
  • Bose, Shambhunath (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kim, Dong-Il (Department of Obstetrics and Gynecology, College of Oriental Medicine, Dongguk University) ;
  • Koo, Byung-Soo (Department of Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Kim, Hojun (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dongguk University)
  • 김형구 (동국대학교 한의과대학 한방재활의학과교실) ;
  • ;
  • 김동일 (동국대학교 한의과대학 한방부인과학교실) ;
  • 구병수 (동국대학교 한의과대학 신경정신과학교실) ;
  • 김호준 (동국대학교 한의과대학 한방재활의학과교실)
  • Received : 2013.12.17
  • Accepted : 2014.01.03
  • Published : 2014.01.31
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Abstract

Objectives This study was performed to evaluate the effects of fermented lotus extracts on prediabetes and hyperlipidemia in high fructose diet rats. Methods Extracts of lotus leaf and lotus root were fermented using 4 different probiotics separately, including Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium breve, and Bifidobacterium longum. Expressions of adipogenic transcription factors including Adiponectin, GLUT-4, Leptin, PPAR gamma, Resistin and Visfatin were analyzed by Real time PCR and Western blotting analysis. Results Fermented lotus extracts reduced blood glucose. Fermented lotus extracts inhibited adipogenic transcription factors by inhibiting preadipocytes differentiation. The level of gene expression of Adiponectin, GLUT-4, Leptin, PPAR gamma, Resistin and Visfatin in relation to that of GAPDH were increase or decrease significantly with the Fermented lotus formulation group. Conclusions Fermented lotus extracts showed hypoglycemic and hypolipidemic effects by inhibiting preadipocyte differentiation and controlling insulin sensitivity in high fructose diet rats.

Keywords

References

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