Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

  • Ren, Yan (Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health (CESP)) ;
  • Kitahara, Cari Meinhold (Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) ;
  • de Gonzalez, Amy Berrington (Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) ;
  • Clero, Enora (Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health (CESP)) ;
  • Brindel, Pauline (Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health (CESP)) ;
  • Maillard, Stephane (Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health (CESP)) ;
  • Cote, Suzanne (Area of population health and optimal health practices, CHU de Quebec Research Center) ;
  • Dewailly, Eric (Area of population health and optimal health practices, CHU de Quebec Research Center) ;
  • Rachedi, Frederique (Territorial Hospital Mamao) ;
  • Boissin, Jean-Louis (IPRAME) ;
  • Sebbag, Joseph (Paofai Clinic) ;
  • Shan, Larrys (Endocrinologist) ;
  • Bost-Bezeaud, Frederique (Territorial Hospital Mamao) ;
  • Petitdidier, Patrick (Laboratoire Boz) ;
  • Xhaard, Constance (Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health (CESP)) ;
  • Rubino, Carole (Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health (CESP)) ;
  • de Vathaire, Florent (Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health (CESP))
  • Published : 2014.07.15
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Abstract

Background: Numerous studies have suggested that selenium deficiency may be associated with an increased risk for several types of cancer, but few have focused on thyroid cancer. Materials and Methods: We examined the association between post-diagnostic fingernail selenium levels and differentiated thyroid cancer risk in a French Polynesian matched case-control study. Conditional logistic regression models were used to estimate odds ratios and 95% confidence intervals. Results: The median selenium concentration among controls was $0.76{\mu}g/g$. Significantly, we found no association between fingernail selenium levels and thyroid cancer risk after conditioning on year of birth and sex and additionally adjusting for date of birth (highest versus lowest quartile: odds-ratio=1.12, 95% confidence interval: 0.66-1.90; p-trend=0.30). After additional adjustment for other covariates, this association remained non-significant (p-trend=0.60). When restricting the analysis to thyroid cancer of 10 mm or more, selenium in nails was non-significantly positively linked to thyroid cancer risk (p-trend=0.09). Although no significant interaction was evidenced between iodine in nails and selenium in nails effect (p=0.70), a non-significant (p-trend =0.10) positive association between selenium and thyroid cancer risk was seen in patients with less than 3 ppm of iodine in nails. The highest fingernail selenium concentration in French Polynesia was in the Marquises Islands ($M=0.87{\mu}g/g$) and in the Tuamotu-Gambier Archipelago ($M=0.86{\mu}g/g$). Conclusions: Our results do not support, among individuals with sufficient levels of selenium, that greater long-term exposure to selenium may reduce thyroid cancer risk. Because these findings are based on post-diagnostic measures, studies with prediagnostic selenium are needed for corroboration.

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