Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

RTN4 3'-UTR Insertion/Deletion Polymorphism and Susceptibility to Non-Small Cell Lung Cancer in Chinese Han Population

  • Lu, De-Yi (Department of Biochemistry and Molecular Biology, Medical School, Soochow University) ;
  • Mao, Xu-Hua (Department of Clinical Laboratory, Yixing People's Hospital) ;
  • Zhou, Ying-Hui (Department of Biochemistry and Molecular Biology, Medical School, Soochow University) ;
  • Yan, Xiao-Long (Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University) ;
  • Wang, Wei-Ping (Department of Biochemistry and Molecular Biology, Medical School, Soochow University) ;
  • Zheng, Ya-Biao (Department of Biochemistry and Molecular Biology, Medical School, Soochow University) ;
  • Xiao, Juan-Juan (Department of Biochemistry and Molecular Biology, Medical School, Soochow University) ;
  • Zhang, Ping (Department of Biochemistry and Molecular Biology, Medical School, Soochow University) ;
  • Wang, Jian-Guo (Department of Biochemistry and Molecular Biology, Medical School, Soochow University) ;
  • Ashwani, Neetika (Department of Biochemistry and Molecular Biology, Medical School, Soochow University) ;
  • Ding, Wei-Liang (Department of Clinical Laboratory, Yixing People's Hospital) ;
  • Jiang, Hua (Internal Medicine, the Second People's Hospital of Xiangcheng District) ;
  • Shang, Yan (Department of Respiratory Diseases, Changhai Hospital, Second Military Medical University) ;
  • Wang, Ming-Hua (Department of Biochemistry and Molecular Biology, Medical School, Soochow University)
  • Published : 2014.07.15
Download PDF
⟨ Previous Next ⟩

Abstract

Nogo protein, encoded by gene reticulon-4 (RTN4), includes three major isoforms by different splicing, named Nogo-A Nogo-B and Nogo-C. Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. RTN4 single nucleotide polymorphisms (SNPs) can influence the efficiency of transcription and translation thus being related with an individual's predisposition to cancer. The CAA insertion/deletion polymorphism (rs34917480) within RTN4 3'-UTR has been reported to be associated with many cancer types. In order to investigate the relationship between this polymorphism and susceptibility to non-small cell lung cancer (NSCLC) in the Chinese population, we conducted the present case-control study including 411 NSCLC patients and 471 unrelated healthy controls. The genotype distributions were significantly different between cases and controls (p=0.014). We found that the del allele could significantly increase NSCLC risk (ins/ins vs ins/del: p=0.007, OR 1.46, 95%CI=1.11-1.93; dominant model: p=0.004, OR 1.47, 95%CI=1.13-1.92 and allele model: p=0.008, OR 1.35, 95%CI=1.08-1.67). This association was stronger in participants over 60 years old, males and smokers. We therefore conclude that the CAA insertion/deletion polymorphism (rs34917480) contributes to non-small cell lung cancer risk in Chinese population. Age, sex and environmental exposure are also related to carcinogenic effects of rs34917480.

Keywords

References

  1. Acevedo L, Yu J, Erdjument-Bromage H, et al (2004). A new role for Nogo as a regulator of vascular remodeling. Nat Med, 10, 382-8. https://doi.org/10.1038/nm1020
  2. Chen Y, Tang X, Cao X, Chen H, Zhang X (2006). Human Nogo-C overexpression induces HEK293 cell apoptosis via a mechanism that involves JNK-c-Jun pathway. Biochem Biophys Res Commun, 348, 923-8. https://doi.org/10.1016/j.bbrc.2006.07.166
  3. Chen YC, Lu DD, Cao XR, Zhang XR (2005). RTN4-C gene expression in hepatocellular carcinoma and its influence on SMMC7721 cell growth and apoptosis. Yi Chuan Xue Bao, 32, 891-7.
  4. GrandPre T, Nakamura F, Vartanian T, Strittmatter SM (2000). Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature, 403, 439-44. https://doi.org/10.1038/35000226
  5. Gray NK, Wickens M (1998). Control of translation initiation in animals. Annu Rev Cell Dev Biol, 14, 399-458. https://doi.org/10.1146/annurev.cellbio.14.1.399
  6. Hecht SS (1999). Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst, 91, 1194-210. https://doi.org/10.1093/jnci/91.14.1194
  7. Jansen RP (2001). mRNA localization: message on the move. Nat Rev Mol Cell Biol, 2, 247-56. https://doi.org/10.1038/35067016
  8. Kuang E, Wan Q, Li X, et al (2006). ER stress triggers apoptosis induced by Nogo-B/ASY overexpression. Exp Cell Res, 312, 1983-8. https://doi.org/10.1016/j.yexcr.2006.02.024
  9. Li Q, Qi B, Oka K, et al (2001). Link of a new type of apoptosis-inducing gene ASY/Nogo-B to human cancer. Oncogene, 20, 3929-36. https://doi.org/10.1038/sj.onc.1204536
  10. Liam CK, Leow HR, How SH, et al (2014). Epidermal growth factor receptor mutations in non- small cell lung cancers in a multiethnic Malaysian patient population. Asian Pac J Cancer Prev, 15, 321-6. https://doi.org/10.7314/APJCP.2014.15.1.321
  11. Mitchell P, Tollervey D (2001). mRNA turnover. Curr Opin Cell Biol, 13, 320-5. https://doi.org/10.1016/S0955-0674(00)00214-3
  12. Novak G, Kim D, Seeman P, Tallerico T (2002). Schizophrenia and Nogo: elevated mRNA in cortex, and high prevalence of a homozygous CAA insert. Brain Res Mol Brain Res, 107, 183-9. https://doi.org/10.1016/S0169-328X(02)00492-8
  13. Novak G, Tallerico T (2006). Nogo A, B and C expression in schizophrenia, depression and bipolar frontal cortex, and correlation of Nogo expression with CAA/TATC polymorphism in 3'-UTR. Brain Res, 1120, 161-71. https://doi.org/10.1016/j.brainres.2006.08.071
  14. Oertle T, Huber C, van der Putten H, Schwab ME (2003). Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4. J Mol Biol, 325, 299-323. https://doi.org/10.1016/S0022-2836(02)01179-8
  15. Piao JM, Shin MH, Kim HN, et al (2013). Glutathione-S-transferase (GSTM1, GSTT1) null phenotypes and risk of lung cancer in a Korean population. Asian Pac J Cancer Prev, 14, 7165-9. https://doi.org/10.7314/APJCP.2013.14.12.7165
  16. Sarkey JP, Chu M, McShane M, et al (2011). Nogo-A knockdown inhibits hypoxia/reoxygenation-induced activation of mitochondrial-dependent apoptosis in cardiomyocytes. J Mol Cell Cardiol, 50, 1044-55. https://doi.org/10.1016/j.yjmcc.2011.03.004
  17. Shi S, Zhou B, Wang Y, et al (2012). Genetic variation in RTN4 3'-UTR and susceptibility to cervical squamous cell carcinoma. DNA Cell Biol, 31, 1088-94. https://doi.org/10.1089/dna.2011.1548
  18. Tagami S, Eguchi Y, Kinoshita M, Takeda M, Tsujimoto Y (2000). A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity. Oncogene, 19, 5736-46. https://doi.org/10.1038/sj.onc.1203948
  19. Tashiro K, Satoh A, Utsumi T, Chung C, Iwakiri Y (2013). Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice. Am J Pathol, 182, 786-95. https://doi.org/10.1016/j.ajpath.2012.11.032
  20. Walsh PS, Metzger DA, Higuchi R (1991). Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques, 10, 506-13.
  21. Watari A, Yutsudo M (2003). Multi-functional gene ASY/Nogo/RTN-X/RTN4: apoptosis, tumor suppression, and inhibition of neuronal regeneration. Apoptosis, 8, 5-9. https://doi.org/10.1023/A:1021639016300
  22. Yang J, Yu L, Bi AD, Zhao SY (2000). Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping. Cytogenet Cell Genet, 88, 101-2. https://doi.org/10.1159/000015499
  23. Zhang K, Bai P, Shi S, et al (2013). Association of genetic variations in RTN4 3'-UTR with risk of uterine leiomyomas. Pathol Oncol Res, 19, 475-9 https://doi.org/10.1007/s12253-013-9604-6
  24. Zheng H, Xue S, Lian F, Wang YY (2011). A novel promising therapy for vein graft restenosis: overexpressed Nogo-B induces vascular smooth muscle cell apoptosis by activation of the JNK/p38 MAPK signaling pathway. Med Hypotheses, 77, 278-81. https://doi.org/10.1016/j.mehy.2011.04.035

Cited by

  1. Identification of module biomarkers from the dysregulated ceRNA–ceRNA interaction network in lung adenocarcinoma vol.11, pp.11, 2015, https://doi.org/10.1039/C5MB00364D
  2. Association of genetic variations in RTN4 3′-UTR with risk for clear cell renal cell carcinoma pp.1573-7292, 2017, https://doi.org/10.1007/s10689-017-0005-y
  3. Association of CAA and TATC Insertion/Deletion Genetic Polymorphisms in RTN4 3′-UTR with Hepatocellular Carcinoma Risk vol.24, pp.1, 2018, https://doi.org/10.1007/s12253-017-0204-8