Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Vitamin D Receptor BsmI Polymorphism and Colorectal Cancer Risk: an Updated Analysis

  • Yu, Kun (Institute of Stem Cell and Developmental Biology, West China Second Hospital, Sichuan University) ;
  • Yang, Jing (Department of Microbiology, Hubei University of Medicine) ;
  • Jiang, Yan (Department of Laboratory Animal Center, Guiyang Medical College) ;
  • Song, Run (Chengdu BioSciTec Biotechnology Co., Ltd.) ;
  • Lu, Qing (Institute of Stem Cell and Developmental Biology, West China Second Hospital, Sichuan University)
  • Published : 2014.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Previous studies have investigated the association between the vitamin D receptor (VDR) BsmI polymorphism and colorectal cancer (CRC) susceptibility, but the results were conflicting. The aim of this study is to quantitatively summarize the relationship between this polymorphism and CRC risk. Materials and Methods: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure (CNKI) and Chinese Biomedicine databases for studies published before November 2013. Summary odds ratios (ORs) and 95% confidence intervals (95%CIs) for VDR BsmI polymorphism and CRC were calculated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. Results: This meta-analysis included 14 case-control studies, which included 10,822 CRC cases and 11,779 controls. Overall, the variant genotype (BB) of the BsmI was associated with a lower CRC risk when compared with the wild-type bb homozygote (OR=0.66, 95%CI: 0.49-0.88). Similarly, a decreased CRC risk was also found in the dominant and recessive models. When stratifying for ethnicity, source of controls, and study sample size, associations were observed among Caucasians, population-based studies and studies with large study sample size (>1000 subjects). Limiting the analysis to the studies within Hardy-Weinberg equilibrium, the results were persistent and robust. No publication bias was found in the present study. Conclusions: This updated meta-analysis suggests that the VDR BsmI polymorphism may be associated with a moderate protective effect against CRC.

Keywords

References

  1. Bai YH, Lu H, Hong D, et al (2012). Vitamin D receptor gene polymorphisms and colorectal cancer risk: a systematic meta-analysis. World J Gastroenterol, 18, 1672-9. https://doi.org/10.3748/wjg.v18.i14.1672
  2. Beelman CA, Parker R (1995). Degradation of mRNA in eukaryotes. Cell, 81, 179-83. https://doi.org/10.1016/0092-8674(95)90326-7
  3. Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101. https://doi.org/10.2307/2533446
  4. Benhamou S, Lee WJ, Alexandrie AK, et al (2002). Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk. Carcinogenesis, 23, 1343-50. https://doi.org/10.1093/carcin/23.8.1343
  5. Cochran WG (1954). The combination of estimates from different experiments.
  6. Biometrics DerSimonian R and Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  7. Du Y, Hu L, Kong F, et al (2014). Lack of association between vitamin D receptor gene BsmI polymorphism and breast cancer risk: an updated meta-analysis involving 23,020 subjects. Tumour Biol, 35, 2087-93. https://doi.org/10.1007/s13277-013-1277-y
  8. Egger M, Davey SG, Schneider M, et al (1997). Bias in metaanalysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  9. Flugge J, Krusekopf S, Goldammer M, et al (2007). Vitamin D receptor haplotypes protect against development of colorectal cancer. Eur J Clin Pharmacol, 63, 997-1005. https://doi.org/10.1007/s00228-007-0367-4
  10. Galbraith RF (1988). A note on graphical presentation of estimated odds ratios from several clinical trials. Stat Med , 7, 889-94. https://doi.org/10.1002/sim.4780070807
  11. Garland CF, Garland FC (1980). Do sunlight and vitamin D reduce the likelihood of colon cancer. Int J Epidemiol, 9, 227-31. https://doi.org/10.1093/ije/9.3.227
  12. Garland CF, Gorham ED, Mohr SB, et al (2009). Vitamin D for cancer prevention: global perspective. Ann Epidemiol , 19, 468-83. https://doi.org/10.1016/j.annepidem.2009.03.021
  13. Giovannucci E (2007). Epidemiological evidence for vitamin D and colorectal cancer. J Bone Miner Res, 22, 81-5. https://doi.org/10.1359/jbmr.07s206
  14. Gunduz M, Cacina C, Toptas B, et al (2012). Association of vitamin D receptor gene polymorphisms with colon cancer. Genet Test Mol Biomarkers, 16, 1058-61. https://doi.org/10.1089/gtmb.2012.0044
  15. Higgins JP, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
  16. Hughes DJ, Hlavata I, Soucek P, et al (2011). Variation in the vitamin D receptor gene is not associated with risk of colorectal cancer in the Czech Republic. J Gastrointest Cancer, 42, 149-54. https://doi.org/10.1007/s12029-010-9168-6
  17. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  18. Jenab M, McKay J, Bueno-de-Mesquita HB, et al (2009). Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations. Cancer Epidemiol. Biomarkers Prev, 18, 2485-91. https://doi.org/10.1158/1055-9965.EPI-09-0319
  19. Jones G, Strugnell SA, DeLuca HF (1998). Current understanding of the molecular actions of vitamin D. Physiol Rev, 78, 1193-231. https://doi.org/10.1152/physrev.1998.78.4.1193
  20. Kadiyska T, Yakulov T, Kaneva R, et al (2007). Vitamin D and estrogen receptor gene polymorphisms and the risk of colorectal cancer in Bulgaria. Int J Colorectal Dis, 22, 395-400. https://doi.org/10.1007/s00384-006-0163-0
  21. Kim HS, Newcomb PA, Ulrich CM, et al (2001). Vitamin D receptor polymorphism and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calcium. Cancer Epidemiol. Biomarkers Prev, 10, 869-74.
  22. Li C, Li Y, Gao LB, et al (2009). Vitamin D receptor gene polymorphisms and the risk of colorectal cancer in a Chinese population. Dig Dis Sci, 54, 634-9. https://doi.org/10.1007/s10620-008-0375-y
  23. Mahmoudi T, Karimi K, Arkani M, et al (2014). Lack of associations between vitamin D metabolism-related gene variants and risk of colorectal cancer. Asian Pac J Cancer Prev, 15, 957-61. https://doi.org/10.7314/APJCP.2014.15.2.957
  24. Mahmoudi T, Karimi K, Mohebbi SR, et al (2011). Start codon FokI and intron 8 BsmI variants in the vitamin D receptor gene and susceptibility to colorectal cancer. Mol Biol Rep, 38, 4765-70. https://doi.org/10.1007/s11033-010-0613-1
  25. Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
  26. Parisi E, Rene JM, Cardus A, et al (2008). Vitamin D receptor levels in colorectal cancer. Possible role of BsmI polymorphism. J Steroid Biochem Mol Biol, 111, 87-90. https://doi.org/10.1016/j.jsbmb.2008.05.001
  27. Park K, Woo M, Nam J, et al (2006). Start codon polymorphisms in the vitamin D receptor and colorectal cancer risk. Cancer Lett, 237, 199-206. https://doi.org/10.1016/j.canlet.2005.05.048
  28. Pilz S, Tomaschitz A, Obermayer-Pietsch B, et al (2009). Epidemiology of vitamin D insufficiency and cancer mortality. Anticancer Res, 29, 3699-704.
  29. Raimondi S, Johansson H, Maisonneuve P, et al (2009). Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Carcinogenesis, 30, 1170-80. https://doi.org/10.1093/carcin/bgp103
  30. Rasool S, Kadla SA, Khan T, et al (2013). Association of a VDR gene polymorphism with risk of colorectal cancer in Kashmir. Asian Pac J Cancer Prev, 14, 5833-7. https://doi.org/10.7314/APJCP.2013.14.10.5833
  31. Slatter ML, Yakumo K, Hoffman M, et al (2001). Variants of the VDR gene and risk of colon cancer (United States). Cancer Causes Control, 12, 359-64. https://doi.org/10.1023/A:1011280518278
  32. Slattery ML, Murtaugh M, Caan B, et al (2004). Associations between BMI, energy intake, energy expenditure, VDR genotype and colon and rectal cancers (United States). Cancer Causes Control, 15, 863-72. https://doi.org/10.1007/s10552-004-1048-6
  33. Slattery ML, Wolff RK, Herrick JS, et al (2007). IL6 genotypes and colon and rectal cancer. Cancer Causes Control, 18, 1095-105. https://doi.org/10.1007/s10552-007-9049-x
  34. Speer G, Cseh K, Winkler G, et al (2001). Oestrogen and vitamin D receptor (VDR) genotypes and the expression of ErbB-2 and EGF receptor in human rectal cancers. Eur J Cancer, 37, 1463-8. https://doi.org/10.1016/S0959-8049(01)00139-3
  35. Sung JJ, Lau JY, Goh KL, et al (2005). Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol, 6, 871-6. https://doi.org/10.1016/S1470-2045(05)70422-8
  36. Theodoratou E, Farrington SM, Tenesa A, et al (2008). Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. Int J Cancer, 123, 2170-9. https://doi.org/10.1002/ijc.23769
  37. Thorne J, Campbell MJ (2008). The vitamin D receptor in cancer. Proc Nutr Soc, 67, 115-27. https://doi.org/10.1017/S0029665108006964
  38. Touvier M, Chan DS, Lau R, et al (2011). Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev, 20, 1003-16. https://doi.org/10.1158/1055-9965.EPI-10-1141
  39. Uitterlinden AG, Fang Y, van Meurs JB, et al (2004). Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states. J Steroid Biochem Mol Biol, 89-90, 187-93. https://doi.org/10.1016/j.jsbmb.2004.03.083
  40. van der Rhee H, Coebergh JW, de Vries E (2009). Sunlight, vitamin D and the prevention of cancer: a systematic review of epidemiological studies. Eur J Cancer Prev, 18, 458-75. https://doi.org/10.1097/CEJ.0b013e32832f9bb1
  41. Zhang Y, Tong SC, Guan LH, et al (2013). Meta-analysis of the relation between vitamin D receptor gene BsmI polymorphism and susceptibility to ovarian cancer. Tumour Biol, 34, 3317-21. https://doi.org/10.1007/s13277-013-0900-2
  42. Zhao P, Dai M, Chen W, et al (2010). Cancer trends in China. Jpn J Clin Oncol, 40, 281-5. https://doi.org/10.1093/jjco/hyp187

Cited by

  1. Association between Circulating Vitamin D, the Taq1 Vitamin D Receptor Gene Polymorphism and Colorectal Cancer Risk among Jordanians vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7337
  2. Associations between Vitamin D Receptor (VDR) Gene Polymorphisms and Colorectal Cancer Risk and Effect Modifications of Dietary Calcium and Vitamin D in a Japanese Population vol.16, pp.5, 2015, https://doi.org/10.7314/APJCP.2015.16.5.2019
  3. Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand vol.16, pp.8, 2015, https://doi.org/10.7314/APJCP.2015.16.8.3339
  4. Associations of Probiotics with Vitamin D and Leptin Receptors and their Effects on Colon Cancer vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.3621
  5. Association of Vitamin D Receptor Gene Polymorphisms with Colorectal Cancer in a Saudi Arabian Population vol.11, pp.6, 2016, https://doi.org/10.1371/journal.pone.0155236
  6. Positive correlation between vitamin D receptor gene FokI polymorphism and colorectal cancer susceptibility in South-Khorasan of Iran vol.119, pp.10, 2018, https://doi.org/10.1002/jcb.26826