Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Relationship of Body Mass Index with Prognosis in Breast Cancer Patients Treated with Adjuvant Radiotherapy and Chemotherapy

  • Published : 2014.05.30
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Abstract

Background: The aim of this study was to investigate the relationship of body mass index with overall and progression-free survival as well as other prognostic factors of breast cancer in patients with non-metastatic breast cancer. Materials and Methods: We retrospectively reviewed 456 patients diagnosed with breast cancer in the Radiation Oncology department of Kayseri Teaching Hospital between 2005 and 2013. We investigated relationship of body mass index with prognosis and other prognostic factors. Results: The study included 456 patients (447 women and 9 men). Mean age at presentation was 55.6 years. Of the cases, 96.9% underwent modified radical mastectomy and 95.0% received chemotherapy, while 82.4% received radiotherapy and 60.0% were given hormone therapy. Body mass index was >25 mg/kg2 in 343 cases. Five- and 10-years overall survival rates were 77% and 58% whereas progression-free survival rates were 65% and 49%, respectively. In univariate analyses, factors including stage (p=0.046), tumor diameter (p=0.001), lymph node metastasis (p=0.006) and body mass index (p=0.030) were found to be significantly associated with overall survival, while perinodal involvement was found to be significantly associated with progression-free survival (p=0.018). In multivariate analysis, stage (p=0.032; OR: 3.8; 95% CI: 1.1-13), tumor diameter (p<0.000; OR: 0.0; 95% CI: 0.0-0.3), lymph node metastasis (p=0.005; OR: 0.0; 95% CI: 0.0-0.5) and BMI (p=0.027; OR: 0.02; 95% CI: 0.0-0.8) remained as significantly associated with OS. Conclusions: In our study, it was seen that overall survival time was shorter in underweight and obese patients when compared to normal weight patients.

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References

  1. Ademuyiwa F, Groman A, O'Connor T, et al (2011). Impact of body mass index on clinical outcomes in triple-negative breast cancer. Cancer, 117, 4132-40. https://doi.org/10.1002/cncr.26019
  2. Alegre MM, Knowles MH, Robison RA, O'Neill KL (2013). Mechanics behind breast cancer prevention-focus on obesity, exercise and dietary fat. Asian Pac J Cancer Prev, 14, 2207-12. https://doi.org/10.7314/APJCP.2013.14.4.2207
  3. Berclaz G, Li S, Price KN, et al (2004). Body mass index as a prognostic feature in operable breast cancer: the International Breast Cancer Study Group experience. Ann Oncol, 15, 875-84. https://doi.org/10.1093/annonc/mdh222
  4. de Azambuja E, McCaskill-Stevens W, Francis P, et al (2010). The effect of body mass index on overall and disease-free survival in node-positive breast cancer patients treated with docetaxel and doxorubicin-containing adjuvant chemotherapy: the experience of the BIG 02-98 trial. Breast Cancer Res Treat, 119, 145-53. https://doi.org/10.1007/s10549-009-0512-0
  5. Engin H, Bilir C, Tekin IO (2013). Prognostic significance of peripheral blood flow cytometry parameters in patients with non-metastatic breast cancer.. Asian Pac J Cancer Prev, 14, 7645-9. https://doi.org/10.7314/APJCP.2013.14.12.7645
  6. Ewertz M, Jensen MB, Gunnarsdottir KA, et al (2011). Effect of obesity on prognosis after early stage breast cancer. J Clin Oncol, 29, 25-31. https://doi.org/10.1200/JCO.2010.29.7614
  7. Goodwin P (2013). Obesity and endocrine therapy: Host factors and breast cancer outcome. The Breast, 22, 44-7. https://doi.org/10.1016/j.breast.2012.03.009
  8. Griggs JJ, Sorbero ME, Lyman GH (2005). Undertreatment of obese women receiving breast cancer chemotherapy. Arch Intern Med, 165, 1267-73. https://doi.org/10.1001/archinte.165.11.1267
  9. Klimant E, Glurich I, Mukesh B, Onitilo A (2011). Blood type, hormone receptor status, HER2/neu status, and survival in breast cancer: A retrospective study exploring relationships in a phenotypically well-defined cohort. Clin Med & Res, 9, 111-8. https://doi.org/10.3121/cmr.2011.907
  10. Ladoire S, Dalban C, Roche H, et al (2014). Effect of obesity on disease-free and overall survival in node-positive breast cancer patients in a large French population: A pooled analysis of two randomised trials. Eur J Cancer, 50, 506-16. https://doi.org/10.1016/j.ejca.2013.11.013
  11. Malcolm AM, Yasantha A, Farhana B, et al (2009). Cancer epidemiology in South Asia - past, present and future. Asian Pac J Cancer Prev, 10, 49-67.
  12. Olmez OF, Evrensel T, Cubukcu E, et al (2013). Prognostic significance of human epidermal receptor (HER)- 3 immunohistochemical expression in patients with metastatic breast cancer. Asian Pac J Cancer Prev, 14, 4115-9. https://doi.org/10.7314/APJCP.2013.14.7.4115
  13. Parekh N, Chandran U, Bandera EV (2012). Obesity in cancer survival. Annu Rev Nutr, 32, 311-42. https://doi.org/10.1146/annurev-nutr-071811-150713
  14. Petrelli JM, Calle EE, Rodriquez C, Thun MJ (2002). Body mass index, height and postemenapausal breast cancer mortality in a prospective cohort of US women. Cancer Causes Control, 13, 325-32. https://doi.org/10.1023/A:1015288615472
  15. Protani M, Coory M, Martin JH (2010). Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis. Breast Cancer Res Treat, 123, 627-35. https://doi.org/10.1007/s10549-010-0990-0
  16. Ryu SY, Kim CB, Nam CM, et al (2001). Is body mass index the prognostic factor in breast cancer? a meta-analysis. J Korean Med Sci, 16, 610-4. https://doi.org/10.3346/jkms.2001.16.5.610
  17. Sestak I, Distler W, Forbes JF, et al (2010). Effect of body mass index on recurrences in tamoxifen and anastrozole treated women: an exploratory analysis from the ATAC trial. J Clin Oncol, 28, 3411-5. https://doi.org/10.1200/JCO.2009.27.2021
  18. Siegel R, Naishadham D, Jemal A (2012). Cancer statistics, 2012. CA Cancer J Clin, 62, 283-98. https://doi.org/10.3322/caac.21153
  19. Suleeporn S, Arkom C, Pattama P, et al (2013). Obesity, diet and physical inactivity and risk of breast cancer in Thai women. Asian Pac J Cancer Prev, 14, 7023-7. https://doi.org/10.7314/APJCP.2013.14.11.7023
  20. Tanriverdi O, Meydan N, Barutca S (2014). Reconsideration of clinical and histopathological prognostic factors in breast cancer patients: a single center experience.. Asian Pac J Cancer Prev, 15, 807-12. https://doi.org/10.7314/APJCP.2014.15.2.807
  21. Wu LZ, Han RQ, Zhou JY, et al (2014). Incidence and mortality of breast cancer in Jiangsu, China. Asian Pac J Cancer Prev, 15, 2727-32. https://doi.org/10.7314/APJCP.2014.15.6.2727
  22. Taghavi A, Fazeli Z, Vahedi M, et al (2012). Incidence trend of breast cancer mortality in Iran. Asian Pac J Cancer Prev, 13, 367-70. https://doi.org/10.7314/APJCP.2012.13.1.367

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